In Vitro Antimicrobial, Antioxidant, and Antispasmodic Activities and the Composition of the Essential Oil of Origanum acutidens (Hand.-Mazz.) Ietswaart
Abstract
The radical scavenging, antimicrobial, and antispasmodic activities and the composition of Origanum acutidens (Hand.-Mazz.) Ietswaart (Order Labiatte) essential oil were evaluated in vitro. Gas chromatography/mass spectrometry analysis of the oil resulted in the identification of 20 compounds, representing 93.61% of the oil; carvacrol (65%) was the main component. The sample was also subjected to a screening for antioxidant activity by using the 1,1-diphenyl-2-picrylhydrazyl and beta-carotene/linoleic acid assays. The essential oil exhibited strong antioxidant activity. Using the agar disk diffusion method, antimicrobial activities of the essential oils were determined for nine microorganisms; antimicrobial activity was shown against eight of them. O. acutidens oil exhibited spontaneous contractions in rat ileum at the 100% level at 0.1 mg/mL level.
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Origanum acutidens essential oil presented antioxidant activity inferior to BHT.
“This oil presented antioxidant activity, but inferior to that of the reference substance used by the authors (BHT).”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [50]
Origanum acutidens essential oil reached an inhibition percentage of 65%, in contrast to 100% for BHT, despite its high carvacrol content.
“In spite of the high percentage of carvacrol present in the oil, the inhibition percentage only reached 65%, in contrast to the 100% of BHT.”
From Antioxidant and Anti-Inflammatory Activities of Essential Oils: A Short Review (2010) · cites this paper as [50]
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- Authors
- Goze, I., Alim, A., Cetinus, S. A., Çetin, A., Durmus, N., Atas, A. T., & Vural, N.
- Affiliations
- Cumhuriyet University
- Ankara University (TR)
- Cumhuriyet University Faculty of Science and Letters
- Sivas Cumhuriyet Üniversitesi (TR)
- Cumhuriyet University School of Medicine
- Tokat Directorate of Health
- Ankara University
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2010-06
- Volume
- 13
- Issue
- 3
- Pages
- 705-709
- ISSN
- 1096-620X (ISSN-L)
- 1557-7600
- OpenAlex
- W2001666124
- Cited by
- 21
- References
- 21
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Medicinal Food (publishedVersion)
- PubMed (publishedVersion)
- AYBU AVESIS (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Insect Pest Control Strategies
- Keywords
- essential oils, carvacrol, antioxidant activity, antimicrobial activity, antispasmodic activity, free radical scavenging, essential oil composition, Lamiaceae
- MeSH terms
- Animals, Anti-Infective Agents, Antioxidants, Bacteria, Candida albicans, Ileum, Male, Muscle Contraction, Oils, Volatile, Parasympatholytics, Plant Oils, Rats, Wistar, Origanum, Rats, In Vitro Techniques
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