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Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon
Abstract
Intestinal enterochromaffin (EC) cell hyperplasia and increased 5-hydroxytryptamine (5-HT) availability play key roles in the pathogenesis of abdominal hypersensitivity of irritable bowel syndrome (IBS). This study aims to study the effect of quercetin on visceral pain and 5-HT availability in postinflammatory IBS (PI-IBS) rats. PI-IBS model rats were administered quercetin by gavage at doses of 5, 10, and 20 mg/kg for 14 days. Compared with normal rats, the visceral pain threshold of PI-IBS rats was markedly decreased and the abdominal motor response to colon distension was markedly increased. The EC cell count and 5-HT level, as well as tryptophan hydroxylase (TPH) protein, were all significantly elevated in PI-IBS rats, while the 5-HT reuptake transporter (serotonin transporter) was reduced. Genes that are responsible for enteroendocrine cell differentiation, that is, Ngn3 and pdx1 , were significantly increased in the PI-IBS group. Quercetin treatment markedly elevated the pain threshold pressure and decreased the visceral motor response of PI-IBS animals; and EC cell density and 5-HT level, as well as TPH expression, in the PI-IBS group were all reduced by quercetin. Quercetin treatment also significantly reduced colonic expression of Ngn3 and pdx1 of PI-IBS. Findings from the present study indicated that the analgesic effect of quercetin on PI-IBS may result from reduction of 5-HT availability in the colon, and the regulatory role of quercetin in endocrine progenitors may contribute to reduced EC cells.
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“One of the bioactive compounds of many Chinese remedies is quercetin, that has been demonstrated to alleviate inflammatory IBS by lowering 5-HT levels, modulating enteroendocrine cell differentiation, and reducing visceral hypersensitivity [110].”
From Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies (2025) · cites this paper as [110]
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Cited by
Natural Remedies for Irritable Bowel Syndrome: A Comprehensive Review of Herbal-Based Therapies
Abalo, R., Gallego-Barceló, P., & Gabbia, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199345 · Cited by 5
Metadata
- Authors
- Qin, H.-Y., Zang, K.-H., Zuo, X., Wu, X.-A., & Bian, Z.-X.
- Affiliations
- Department of Pharmacy, First Hospital of Lanzhou University, Lanzhou, China.
- College of Pharmacy, Gansu University of Traditional Chinese Medicine, Lanzhou, China.
- Lab of Brain and Gut Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
- Venue
- Journal of Medicinal Food
- Publisher
- SAGE Publications
- Published
- 2019-07
- Volume
- 22
- Issue
- 7
- Pages
- 663-671
- ISSN
- 1096-620X
- 1557-7600
- Cited by
- 55
- References
- 5
- Language
- en
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
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- Qin, H.-Y., Zang, K.-H., Zuo, X., Wu, X.-A., & Bian, Z.-X. (2019). Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon. Journal of Medicinal Food. https://doi.org/10.1089/jmf.2018.4264
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