Recent developments in the pathophysiology of irritable bowel syndrome

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

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Identification of stem cells in small intestine and colon by marker gene Lgr5

Barker, N., van Es, J. H., Kuipers, J., Kujala, P., van den Born, M., Cozijnsen, M., Haegebarth, A., Korving, J., Begthel, H., Peters, P. J., et al. (2007) · Nature · doi:10.1038/nature06196 · Cited by 5,687 · see citing works

Functional Bowel Disorders

Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856 · see citing works

The gut microbiota--masters of host development and physiology

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Organoid Models and Applications in Biomedical Research

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Gut hormone PYY3-36 physiologically inhibits food intake

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Burden of Gastrointestinal Disease in the United States: 2012 Update

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Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine V. Unitarian theory of the origin of the four epithelial cell types

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Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

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Inhibition of Food Intake in Obese Subjects by Peptide YY _3–36

Batterham, R. L., Cohen, M. A., Ellis, S. M., Le Roux, C. W., Withers, D. J., Frost, G. S., Ghatei, M. A., & Bloom, S. R. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030204 · Cited by 1,604 · see citing works

The burden of selected digestive diseases in the United States

Sandler, R. S., Everhart, J. E., Donowitz, M., Adams, E., Cronin, K., Goodman, C., Gemmen, E., Shah, S., Avdic, A., & Rubin, R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32978 · Cited by 1,512 · see citing works

AGA technical review on irritable bowel syndrome.

Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works

Liver regeneration

Fausto, N., Campbell, J. S., & Riehle, K. J. (2006) · Hepatology · doi:10.1002/hep.20969 · Cited by 1,378 · see citing works

A Diet Low in FODMAPs Reduces Symptoms of Irritable Bowel Syndrome

Halmos, E. P., Power, V. A., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2014) · Gastroenterology · doi:10.1053/j.gastro.2013.09.046 · Cited by 1,249 · see citing works

Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute <i>Campylobacter</i> enteritis and in post-dysenteric irritable bowel syndrome

Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155 · see citing works

Spectrum of gluten-related disorders: consensus on new nomenclature and classification

Sapone, A., Bai, J. C., Ciacci, C., Dolinšek, J., Green, P. H. R., Hadjivassiliou, M., Kaukinen, K., Rostami, K., Sanders, D. S., Schümann, M., et al. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-13 · Cited by 1,139 · see citing works

Global and Deep Molecular Analysis of Microbiota Signatures in Fecal Samples From Patients With Irritable Bowel Syndrome

Rajilić–Stojanović, M., Biagi, E., Heilig, H. G. H. J., Kajander, K., Kekkonen, R. A., Tims, S., & de Vos, W. M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.043 · Cited by 1,041 · see citing works

The Fecal Microbiota of Irritable Bowel Syndrome Patients Differs Significantly From That of Healthy Subjects

Kassinen, A., Krogius-Kurikka, L., Mäkivuokko, H., Rinttilä, T., Paulin, L., Corander, J., Malinen, E., Apajalahti, J., & Palva, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.04.005 · Cited by 1,002 · see citing works

XVI. International Union of Pharmacology Recommendations for the Nomenclature of Neuropeptide Y, Peptide YY, and Pancreatic Polypeptide Receptors

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Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease

Swidsinski, A., Weber, J., Loening-Baucke, V., Hale, L. P., & Lochs, H. (2005) · Journal of Clinical Microbiology · doi:10.1128/jcm.43.7.3380-3389.2005 · Cited by 894 · see citing works

The migration of neural crest cells to the wall of the digestive tract in avian embryo

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An irritable bowel syndrome subtype defined by species-specific alterations in faecal microbiota

Jeffery, I. B., O'Toole, P. W., Öhman, L., Claesson, M. J., Deane, J., Quigley, E. M. M., & Simrén, M. (2012) · Gut · doi:10.1136/gutjnl-2011-301501 · Cited by 835 · see citing works

Activation of the mucosal immune system in irritable bowel syndrome

Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833 · see citing works

No Effects of Gluten in Patients With Self-Reported Non-Celiac Gluten Sensitivity After Dietary Reduction of Fermentable, Poorly Absorbed, Short-Chain Carbohydrates

Biesiekierski, J. R., Peters, S., Newnham, E., Rosella, O., Muir, J. G., & Gibson, P. R. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.051 · Cited by 794 · see citing works

The role of psychological and biological factors in postinfective gut dysfunction

Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764 · see citing works

Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome 1 ☆

Coates, M. D., Mahoney, C. R., Linden, D. R., Sampson, J. E., Chen, J. C., Blaszyk, H., Crowell, M. D., Sharkey, K. A., Gershon, M. D., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.013 · Cited by 761 · see citing works

Gluten Causes Gastrointestinal Symptoms in Subjects Without Celiac Disease: A Double-Blind Randomized Placebo-Controlled Trial

Biesiekierski, J. R., Newnham, E., Irving, P. M., Barrett, J. S., Haines, M. L., Doecke, J. D., Shepherd, S., Muir, J. G., & Gibson, P. R. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.487 · Cited by 712 · see citing works

Analysis of the Fecal Microbiota of Irritable Bowel Syndrome Patients and Healthy Controls with Real-Time PCR

Malinen, E., Rinttila, T., Kajander, K., Matto, J., Kassinen, A., Krogius, L., Saarela, M., Korpela, R., & Palva, A. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.40312.x · Cited by 699 · see citing works

Diets that differ in their FODMAP content alter the colonic luminal microenvironment

Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2015) · Gut · doi:10.1136/gutjnl-2014-307264 · Cited by 681 · see citing works

Gastrointestinal microbiome signatures of pediatric patients with irritable bowel syndrome

Saulnier, D. M., Riehle, K., Mistretta, T., Diaz, M., Mandal, D., Raza, S., Weidler, E. M., Qin, X., Coarfa, C., Milosavljevic, A., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.072 · Cited by 672 · see citing works

Immune Activation in Patients With Irritable Bowel Syndrome

Liebregts, T., Adam, B., Bredack, C., Röth, A., Heinzel, S., Lester, S., Downie–Doyle, S., Smith, E., Drew, P., Talley, N. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.046 · Cited by 660 · see citing works

Evidence‐based dietary management of functional gastrointestinal symptoms: The FODMAP approach

Gibson, P. R., & Shepherd, S. (2009) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2009.06149.x · Cited by 657 · see citing works

Self-Reported Food-Related Gastrointestinal Symptoms in IBS Are Common and Associated With More Severe Symptoms and Reduced Quality of Life

Böhn, L., Störsrud, S., Törnblom, H., Bengtsson, U., & Simrén, M. (2013) · American Journal of Gastroenterology · doi:10.1038/ajg.2013.105 · Cited by 655 · see citing works

American College of Gastroenterology Monograph on the Management of Irritable Bowel Syndrome and Chronic Idiopathic Constipation

Ford, A. C., Moayyedi, P., Lacy, B. E., Lembo, A. J., Saito, Y. A., Schiller, L. R., Soffer, E., Spiegel, B. M. R., & Quigley, E. M. M. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.187 · Cited by 648 · see citing works

A population study of food intolerance

YOUNG, E. (1994) · The Lancet · doi:10.1016/s0140-6736(94)90234-8 · Cited by 645 · see citing works

The intestinal stem cell

Barker, N., van de Wetering, M., & Clevers, H. (2008) · Genes &amp; Development · doi:10.1101/gad.1674008 · Cited by 629 · see citing works

Pathogenesis of IBS: role of inflammation, immunity and neuroimmune interactions

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5-Hydroxytryptamine (serotonin) in the gastrointestinal tract

Gershon, M. D. (2013) · Current Opinion in Endocrinology, Diabetes &amp; Obesity · doi:10.1097/med.0b013e32835bc703 · Cited by 617 · see citing works

Role for protease activity in visceral pain in irritable bowel syndrome

Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · see citing works

Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS

Dunlop, S. P., Jenkins, D., Neal, K. R., & Spiller, R. C. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.028 · Cited by 583 · see citing works

Manipulation of dietary short chain carbohydrates alters the pattern of gas production and genesis of symptoms in irritable bowel syndrome

Ong, D. K., Mitchell, S. B., Barrett, J. S., Shepherd, S. J., Irving, P. M., Biesiekierski, J. R., Smith, S., Gibson, P. R., & Muir, J. G. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06370.x · Cited by 583 · see citing works

Regulation of early lung morphogenesis: questions, facts and controversies

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Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

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Food-Related gastrointestinal symptoms in the irritable bowel syndrome

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Endocrine cells in human intestine: an immunocytochemical study

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Regulatory phases of early liver development: paradigms of organogenesis

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Non-Celiac Gluten Sensitivity: The New Frontier of Gluten Related Disorders

Catassi, C., Bai, J. C., Bonaz, B. L., Bouma, G., Calabrò, A., Carroccio, A., Castillejo, G., Ciacci, C., Cristofori, F., Dolinšek, J., et al. (2013) · Nutrients · doi:10.3390/nu5103839 · Cited by 493 · see citing works

Intestinal microbiota, diet and health

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Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome

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Non-colonic features of irritable bowel syndrome.

Whorwell, P. J., McCallum, M., Creed, F. H., & Roberts, C. T. (1986) · Gut · doi:10.1136/gut.27.1.37 · Cited by 473 · see citing works

Medical costs in community subjects with irritable bowel syndrome

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Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology

Levy, R. L., Jones, K. R., Whitehead, W. E., Feld, S. I., Talley, N. J., & Corey, L. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.27995 · Cited by 458 · see citing works

A Controlled Trial of Gluten-Free Diet in Patients With Irritable Bowel Syndrome-Diarrhea: Effects on Bowel Frequency and Intestinal Function

Vázquez‐Roque, M. I., Camilleri, M., Smyrk, T. C., Murray, J. A., Marietta, E. V., O’Neill, J., Carlson, P., Lamsam, J. L., Janzow, D., Eckert, D. J., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.01.049 · Cited by 454 · see citing works

Divergence of gut permeability and mucosal immune gene expression in two gluten-associated conditions: celiac disease and gluten sensitivity

Sapone, A., Lammers, K. M., Casolaro, V., Cammarota, M., Giuliano, M. T., De Rosa, M., Stefanile, R., Mazzarella, G., Tolone, C., Russo, M. I., et al. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-23 · Cited by 452 · see citing works

Ileal brake: a sensible food target for appetite control. A review

Maljaars, P. W. J., Peters, H. P. F., Mela, D. J., & Masclee, A. A. M. (2008) · Physiology &amp; Behavior · doi:10.1016/j.physbeh.2008.07.018 · Cited by 451 · see citing works

Alterations in composition and diversity of the intestinal microbiota in patients with diarrhea‐predominant irritable bowel syndrome

Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., & Ringel, Y. (2012) · Neurogastroenterology &amp; Motility · doi:10.1111/j.1365-2982.2012.01891.x · Cited by 425 · see citing works

Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome

Gwee, K.-A. (2003) · Gut · doi:10.1136/gut.52.4.523 · Cited by 415 · see citing works

The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome

Klooker, T. K., Braak, B., Koopman, K. E., Welting, O., Wouters, M. M., der Heide, S. V., Schemann, M., Bischoff, S. C., van den Wijngaard, R. M., & Boeckxstaens, G. E. (2010) · Gut · doi:10.1136/gut.2010.213108 · Cited by 413 · see citing works

Non-Celiac Wheat Sensitivity Diagnosed by Double-Blind Placebo-Controlled Challenge: Exploring a New Clinical Entity

Carroccio, A., Mansueto, P., Iacono, G., Soresi, M., D’Alcamo, A., Cavataio, F., Brusca, I., Florena, A. M., Ambrosiano, G., Seidita, A., et al. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.236 · Cited by 404 · see citing works

Dietary poorly absorbed, short‐chain carbohydrates increase delivery of water and fermentable substrates to the proximal colon

Barrett, J. S., Gearry, R. B., Muir, J. G., Irving, P. M., ROSE, R., Rosella, O., Haines, M. L., Shepherd, S., & Gibson, P. G. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04237.x · Cited by 403 · see citing works

Ligand-induced redistribution of a human KDEL receptor from the Golgi complex to the endoplasmic reticulum

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Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome

Camilleri, M., Lasch, K. L., & Zhou, W. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00155.2012 · Cited by 397 · see citing works

Small Intestinal Bacterial Overgrowth: A Framework for Understanding Irritable Bowel Syndrome

Lin, H. C. (2004) · JAMA · doi:10.1001/jama.292.7.852 · Cited by 396 · see citing works

Personal view: food for thought – western lifestyle and susceptibility to Crohn's disease. The FODMAP hypothesis

Gibson, P. R., & Shepherd, S. (2005) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2005.02506.x · Cited by 391 · see citing works

Association of adult coeliac disease with irritable bowel syndrome: a case-control study in patients fulfilling ROME II criteria referred to secondary care

Sanders, D. S., Carter, M. J., Hurlstone, D. P., Pearce, A., Ward, A. M., McAlindon, M. E., & Lobo, A. J. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06581-3 · Cited by 390 · see citing works

Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis

Wang, L.-H., Fang, X.-C., & Pan, G.-Z. (2004) · Gut · doi:10.1136/gut.2003.021154 · Cited by 387 · see citing works

Enteroendocrine cells: a site of 'taste' in gastrointestinal chemosensing

Sternini, C., Anselmi, L., & Rozengurt, E. (2008) · Current Opinion in Endocrinology, Diabetes &amp; Obesity · doi:10.1097/med.0b013e3282f43a73 · Cited by 377 · see citing works

Perceived food intolerance in subjects with irritable bowel syndrome--etiology, prevalence and consequences

Monsbakken, K. W., Vandvik, P. O., & Farup, P. G. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602367 · Cited by 364 · see citing works

Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome

Dunlop, S. P., Coleman, N. S., Blackshaw, E., Perkins, A. C., Singh, G., Marsden, C. A., & Spiller, R. E. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00726-8 · Cited by 355 · see citing works

Metabolomics of Fecal Extracts Detects Altered Metabolic Activity of Gut Microbiota in Ulcerative Colitis and Irritable Bowel Syndrome

Le Gall, G., Noor, S. O., Ridgway, K., Scovell, L., Jamieson, C., Johnson, I. T., Colquhoun, I. J., Kemsley, E. K., & Narbad, A. (2011) · Journal of Proteome Research · doi:10.1021/pr2003598 · Cited by 348 · see citing works

Gastrointestinal hormones regulating appetite

Chaudhri, O. B., Small, C. J., & Bloom, S. R. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1856 · Cited by 347 · see citing works

Quantification of fructans, galacto-oligosacharides and other short-chain carbohydrates in processed grains and cereals

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Mucosal Immune Activation in Irritable Bowel Syndrome: Gender-Dependence and Association With Digestive Symptoms

Cremon, C., Gargano, L., Morselli-Labate, A. M., Santini, D., Cogliandro, R. F., De Giorgio, R., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2008.94 · Cited by 342 · see citing works

Faecal microbiota composition and host–microbe cross-talk following gastroenteritis and in postinfectious irritable bowel syndrome

Jalanka-Tuovinen, J., Salojärvi, J., Salonen, A., Immonen, O., Garsed, K., Kelly, F. M., Zaitoun, A., Palva, A., Spiller, R. C., & de Vos, W. M. (2014) · Gut · doi:10.1136/gutjnl-2013-305994 · Cited by 340 · see citing works

FOOD INTOLERANCE: A MAJOR FACTOR IN THE PATHOGENESIS OF IRRITABLE BOWEL SYNDROME

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ORGANIC AND FUNCTIONAL DISORDERS IN 2000 GASTROENTEROLOGY OUTPATIENTS

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Measurement of Short-Chain Carbohydrates in Common Australian Vegetables and Fruits by High-Performance Liquid Chromatography (HPLC)

Muir, J. G., Rose, R., Rosella, O., Liels, K., Barrett, J. S., Shepherd, S., & Gibson, P. R. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf802700e · Cited by 331 · see citing works

Minireview: Development and Differentiation of Gut Endocrine Cells

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Mutant Neurogenin-3 in Congenital Malabsorptive Diarrhea

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Classification and functions of enteroendocrine cells of the lower gastrointestinal tract

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Microbial community analysis reveals high level phylogenetic alterations in the overall gastrointestinal microbiota of diarrhoea-predominant irritable bowel syndrome sufferers

Krogius-Kurikka, L., Lyra, A., Malinen, E., Aarnikunnas, J., Tuimala, J., Paulin, L. G., Mäkivuokko, H., Kajander, K., & Palva, A. (2009) · BMC Gastroenterology · doi:10.1186/1471-230x-9-95 · Cited by 307 · see citing works

Food intolerance and the irritable bowel syndrome.

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Intestinal Microflora

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Ciliated epithelial cell lifespan in the mouse trachea and lung

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