Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction

Wheatcroft, J.; Wakelin, D.; Smith, A.; Mahoney, C. R.; Mawe, G.; Spiller, R.

doi:10.1111/j.1365-2982.2005.00719.x

Cited by 206Gastrointestinal motility and disordersMast cells and histamineParasites and Host Interactions

Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction

Wheatcroft, J., Wakelin, D., Smith, A., Mahoney, C. R., Mawe, G., Spiller, R.·2005·Neurogastroenterology & Motility

DOI 10.1111/j.1365-2982.2005.00719.x

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Abstract

Abstract Patients with postinfective irritable bowel syndrome and Trichinella spiralis‐infected mice share many features including visceral hypersensitivity and disordered motility. We assessed enterochromaffin (EC) numbers and serotonin transporter (SERT) using National Institute of Health (NIH) female mice studied for up to 56 days post‐T. spiralis infection. The effects of steroid treatment and the T‐cell dependence of the observed responses were assessed by infection of hydrocortisone‐treated or T‐cell receptor knock out [TCR (β×δ) KO] animals. Enterochromaffin cell density in uninfected animals increased from duodenum 10.0 cells mm−2 (5.9–41.0) to colon 61.8. (46.3–162) cells mm−2P < 0.0001. Infection increased duodenal and jejunal counts which rose to 37.3 (22–57.7) cells mm−2 and 50.6 (7–110.8) cells mm−2, respectively, at day 14. Infection significantly reduced jejunal SERT expression, with luminance values falling from 61.0 (45.1–98.3) to a nadir of 11.6 (0–36.0) units at day 9, P < 0.001. Specific deficiencies in all T cells reduced EC hyperplasia and abrogated infection‐induced mastocytosis. Thus infection induced inflammation increases EC numbers, as has been reported in PI‐IBS, and reduces SERT. This may increase mucosal 5HT availability and contribute to the clinical presentation of PI‐IBS.

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A mechanism of this type might explain the reported upregulation of mucosal serotonin in a mouse model of postinfectious bowel dysfunction.
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From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [66]

Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute <i>Campylobacter</i> enteritis and in post-dysenteric irritable bowel syndrome
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155 · see citing works
Self-citation
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764 · see citing works
Molecular defects in mucosal serotonin content and decreased serotonin reuptake transporter in ulcerative colitis and irritable bowel syndrome 1 ☆
Coates, M. D., Mahoney, C. R., Linden, D. R., Sampson, J. E., Chen, J. C., Blaszyk, H., Crowell, M. D., Sharkey, K. A., Gershon, M. D., & Mawe, G. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.03.013 · Cited by 761 · see citing works
Self-citation
Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
Dunlop, S. P., Jenkins, D., Neal, K. R., & Spiller, R. C. (2003) · Gastroenterology · doi:10.1053/j.gastro.2003.09.028 · Cited by 583 · see citing works
Self-citation
Endocrine cells in human intestine: an immunocytochemical study
Sjölund, K., Sandén, G., Håkanson, R., & Sundler, F. (1983) · Gastroenterology · doi:10.1016/s0016-5085(83)80080-8 · Cited by 520 · see citing works
Increased rectal mucosal expression of interleukin 1beta in recently acquired post-infectious irritable bowel syndrome
Gwee, K.-A. (2003) · Gut · doi:10.1136/gut.52.4.523 · Cited by 415 · see citing works
Bacillary dysentery as a causative factor of irritable bowel syndrome and its pathogenesis
Wang, L.-H., Fang, X.-C., & Pan, G.-Z. (2004) · Gut · doi:10.1136/gut.2003.021154 · Cited by 387 · see citing works
Distinctive Clinical, Psychological, and Histological Features of Postinfective Irritable Bowel Syndrome
Dunlop, S. P., Jenkins, D., & Spiller, R. C. (2003) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07542.x · Cited by 359 · see citing works
Self-citation
Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract
Wade, P., Chen, J., Jaffe, B. M., Kassem, I., Blakely, R., & Gershon, M. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02352.1996 · Cited by 328 · see citing works
Evolving pathophysiologic models of functional gastrointestinal disorders
Mayer, E. A., & Collins, S. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33584 · Cited by 326 · see citing works
Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis
Linden, D. R., Chen, J.-X., Gershon, M. D., Sharkey, K. A., & Mawe, G. M. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00488.2002 · Cited by 291 · see citing works
Self-citation
Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women
Yeo, A., Boyd, P., Lumsden, S., Saunders, T., Handley, A., Stubbins, M., Knaggs, A., Asquith, S., Taylor, I., Bahari, B., et al. (2004) · Gut · doi:10.1136/gut.2003.035451 · Cited by 260 · see citing works
Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies
Qian, Y., Melikian, H. E., Rye, D., Levey, A. I., & Blakely, R. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01261.1995 · Cited by 254 · see citing works
Visceral hyperalgesia and intestinal dysmotility in a mouse model of postinfective gut dysfunction
Berčík, P., Wang, L., Verdu, E. F., Mao, Y., Blennerhassett, P. A., Khan, W. I., Kean, I. R. L., Tougas, G. H., & Collins, S. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.006 · Cited by 218 · see citing works
Human ileal bile acid transporter gene ASBT ( SLC10A2 ) is transactivated by the glucocorticoid receptor
Jung, D., Fantin, A. C., Scheurer, U., Fried, M., & Kullak-Ublick, G. A. (2003) · Gut · doi:10.1136/gut.53.1.78 · Cited by 188 · see citing works
Randomized, double‐blind, placebo‐controlled trial of prednisolone in post‐infectious irritable bowel syndrome
Dunlop, S., Jenkins, D., Neal, K. R., Næsdal, J., Borgaonker, M., Collins, S. M., & Spiller, R. E. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01640.x · Cited by 178 · see citing works
Self-citation
Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor
Jung, D., Fantin, A. C., Scheurer, U., Fried, M., & Kullak-Ublick, G. A. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)80515-2 · Cited by 170 · see citing works
Immunity to primary and challenge infections of Trichinella spiralis in mice: a re-examination of conventional parameters
Wakelin, D., & Lloyd, M. (1976) · Parasitology · doi:10.1017/s0031182000048472 · Cited by 145 · see citing works
Self-citation
Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis
O'Hara, J. R., Ho, W., Linden, D. R., Mawe, G. M., & Sharkey, K. A. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00090.2004 · Cited by 139 · see citing works
Self-citation
The in vivo role of stem cell factor (c‐kit ligand) on mastocytosis and host protective immunity to the intestinal nematode Trichinella spiralis in mice
Grencis, R. K., Else, K. J., Huntley, J. F., & Nishikawa, S. (1993) · Parasite Immunology · doi:10.1111/j.1365-3024.1993.tb00572.x · Cited by 109 · see citing works
Impaired acetylcholine release from the myenteric plexus of Trichinella-infected rats
Collins, S. M., Blennerhassett, P. A., Blennerhassett, M. G., & Vermillion, D. L. (1989) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1989.257.6.g898 · Cited by 106 · see citing works
Increased intestinal muscle contractility and worm expulsion in nematode-infected mice
Vallance, B. A., Blennerhassett, P. A., & Collins, S. M. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.272.2.g321 · Cited by 99 · see citing works
Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis-infected mice
Kamal, M., Wakelin, D., Ouellette, A. J., Smith, A. L., Podolsky, D. K., & Mahida, Y. R. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01589.x · Cited by 83 · see citing works
Self-citation
Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation
Chen, F., Ma, L., Sartor, R. B., Li, F., Xiong, H., Sun, A., & Shneider, B. L. (2002) · Gastroenterology · doi:10.1053/gast.2002.37055 · Cited by 71 · see citing works
T-lymphocyte modulation of intestinal muscle function in the Trichinella-infected rat
Vermillion, D. L., Ernst, P. B., & Collins, S. M. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90456-u · Cited by 64 · see citing works
Platelet Serotonin Transporter in Patients With Diarrhea-Predominant Irritable Bowel Syndrome Both Before and After Treatment With Alosetron
Bellini, M., Rappelli, L., Blandizzi, C., Costa, F., Stasi, C., Colucci, R., Giannaccini, G., Marazziti, D., Betti, L., Baroni, S., et al. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.08669.x · Cited by 64 · see citing works
Rapid changes in the surface of parasitic nematodes during transition from pre- to post-parasitic forms
Proudfoot, L., Kusel, J. R., Smith, H. V., Harnett, W., Worms, M. J., & Kennedy, M. W. (1993) · Parasitology · doi:10.1017/s0031182000079464 · Cited by 60 · see citing works
Effects of Cortisone on Trichinella spiralis Infections in Non-Immunized Mice
Coker, C. M. (1955) · Journal of Parasitology · doi:10.2307/3273810 · Cited by 50 · see citing works
Hymenolepis diminuta: changes in intestinal morphology and the enterochromaffin cell population associated with infection in male C57 mice
McKay, D. M., Halton, D. W., Johnston, C. F., Fairweather, I., & Shaw, C. (1990) · Parasitology · doi:10.1017/s0031182000079816 · Cited by 29 · see citing works
Mucosal responses to infection withTrichinella spiralisin mice
Kamal, M., Wakelin, D., & Mahida, Y. R. (2001) · Parasite · doi:10.1051/parasite/200108s2110 · Cited by 13 · see citing works
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Impaired Uptake of Serotonin by Platelets From Patients With Irritable Bowel Syndrome Correlates With Duodenal Immune Activation
Foley, S., Garsed, K. C., Singh, G., Duroudier, N. P., Swan, C., Hall, I. P., Zaitoun, A. M., Bennett, A. J., Marsden, C. A., Holmes, G. K. T., et al. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.052 · Cited by 140 · see citing works
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Lomax, A. E., Linden, D. R., Mawe, G. M., & Sharkey, K. A. (2006) · Autonomic Neuroscience · doi:10.1016/j.autneu.2006.02.015 · Cited by 127 · see citing works
Self-citation
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“9% saline), while mice in the control group received the same volume of normal saline [20].”
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Self-citation
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Review: Enteroendocrine cells: Neglected players in gastrointestinal disorders?
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van Kerkhoven, L. A. S., Laheij, R. J. F., & Jansen, J. B. �. �. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03453.x · Cited by 93 · see citing works
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Rijnierse, A., Nijkamp, F. P., & Kraneveld, A. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.06.008 · Cited by 105 · see citing works
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Bistoletti, M., Bosi, A., Banfi, D., Giaroni, C., & Baj, A. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.08.012 · Cited by 88 · see citing works
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Keating, C. D., Beyak, M. J., Foley, S., Singh, G., Marsden, C. A., Spiller, R. E., & Grundy, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156984 · Cited by 88 · see citing works
Self-citation
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Lomax, A. E., O’Hara, J. R., Hyland, N. P., Mawe, G. M., & Sharkey, K. A. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00355.2006 · Cited by 87 · see citing works
Self-citation
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Diefenbach, A., Gnafakis, S., & Shomrat, O. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.016 · Cited by 82 · see citing works
Enteropathogenic Escherichia coli Infection Inhibits Intestinal Serotonin Transporter Function and Expression
Esmaili, A., Nazir, S. F., Borthakur, A., Yu, D., Turner, J. R., Saksena, S., Singla, A., Hecht, G. A., Alrefai, W. A., & Gill, R. K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.002 · Cited by 82 · see citing works
Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome
Jin, D., Cao, H., Xu, M., Wang, S.-N., Wang, Y., Yan, F., & Wang, B. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i36.8137 · Cited by 82 · see citing works
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Motomura, Y., Ghia, J., Wang, H., Akiho, H., El–Sharkawy, R. T., Collins, M., Wan, Y., McLaughlin, J. T., & Khan, W. I. (2008) · Gut · doi:10.1136/gut.2007.129296 · Cited by 80 · see citing works
Human Intestinal Enteroids With Inducible Neurogenin-3 Expression as a Novel Model of Gut Hormone Secretion
Chang‐Graham, A. L., Danhof, H. A., Engevik, M. A., Tomaro-Duchesneau, C., Karandikar, U. C., Estes, M. K., Versalovic, J. A., Britton, R. A., & Hyser, J. M. (2019) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2019.04.010 · Cited by 78 · see citing works
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Guseva, D., Holst, K., Kaune, B., Meier, M., Keubler, L. M., Glage, S., Büettner, M., Bleich, A., Pabst, O., Bachmann, O. P., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000150 · Cited by 78 · see citing works
Enteric Microbiota-Mediated Serotonergic Signaling in Pathogenesis of Irritable Bowel Syndrome
Mishima, Y., & Ishihara, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910235 · Cited by 77 · see citing works
The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling
Yu, Y., Wu, S.-J., Li, J., Wang, R., Xie, X., Yu, X., Pan, J., Xu, Y., & Zheng, L. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9554-z · Cited by 73 · see citing works
Serotonin Synthesis and Uptake in Symptomatic Patients With Crohn’s Disease in Remission
Minderhoud, I. M., Oldenburg, B., Schipper, M. E. I., Linde, J. J. M. T., & Samsom, M. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.02.013 · Cited by 69 · see citing works
Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation
Kim, J., Wang, H., Terc, J. D., Zambrowicz, B., Yang, Q., & Khan, W. I. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00299.2014 · Cited by 68 · see citing works
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Shah, P. A., Park, C. J., Shaughnessy, M. P., & Cowles, R. A. (2021) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2021.05.008 · Cited by 67 · see citing works
Serotonin transporter gene (SLC6A4) polymorphism in patients with irritable bowel syndrome and healthy controls.
Kumar, S., Ranjan, P., Mittal, B., & Ghoshal, U. C. (2012) · PubMed · Cited by 61 · see citing works
Physiological changes in the gastrointestinal tract and host protective immunity: learning from the mouse-Trichinella spiralismodel
Khan, W. I. (2008) · Parasitology · doi:10.1017/s0031182008004381 · Cited by 60 · see citing works
Colonic Mucosal Immune Activity in Irritable Bowel Syndrome: Comparison with Healthy Controls and Patients with Ulcerative Colitis
Ahn, J. Y., Lee, K. H., Choi, C. H., Kim, J. W., Lee, H. W., Kim, J. W., Kim, M. K., Kwon, G. Y., Han, S., Kim, S., et al. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2930-4 · Cited by 59 · see citing works
Mast Cell Stabilizer Ketotifen [4-(1-Methyl-4-piperidylidene)-4 H-benzo[4,5]cyclohepta[1,2-b]thiophen-10(9 H)-one Fumarate] Prevents Mucosal Mast Cell Hyperplasia and Intestinal Dysmotility in Experimental Trichinella spiralis Inflammation in the Rat
de la Serna, H., Porras, M., & Vergara, P. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.104620 · Cited by 60 · see citing works
Quercetin Attenuates Visceral Hypersensitivity and 5-Hydroxytryptamine Availability in Postinflammatory Irritable Bowel Syndrome Rats: Role of Enterochromaffin Cells in the Colon
Qin, H., Zang, K., Xiao, Z., Wu, X.-A., & Bian, Z. (2019) · Journal of Medicinal Food · doi:10.1089/jmf.2018.4264 · Cited by 58 · see citing works
Changing views on diverticular disease: impact of aging, obesity, diet, and microbiota
Spiller, R. (2015) · Neurogastroenterology and Motility · doi:10.1111/nmo.12526 · Cited by 56 · see citing works
Self-citation
Irritable Bowel Syndrome in Persons Who Acquired Trichinellosis
Soytürk, M., Akpınar, H., Gürler, O., Pozio, E., Sarı, İ., Akar, S., Akarsu, M., Bırlık, M., Önen, F., & Akkoç, N. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01084.x · Cited by 57 · see citing works
Acupuncture-moxibustion in treating irritable bowel syndrome: How does it work?
Ma, X. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i20.6044 · Cited by 56 · see citing works
Contribution of Gender to Pathophysiology and Clinical Presentation of IBS: Should Management Be Different in Women?
Ouyang, A., & Wrzos, H. F. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00975.x · Cited by 57 · see citing works
Histopathological alterations in irritable bowel syndrome
Kirsch, R., & Riddell, R. H. (2006) · Modern Pathology · doi:10.1038/modpathol.3800704 · Cited by 57 · see citing works
Pathogenic mechanisms of postinfectious functional gastrointestinal disorders: Results 3 years after gastroenteritis
Mearin, F., Juan, A. P., Balboa, A., Perona, M. C., Sans, M., Salas, A., Angulo, S., Lloreta, J., Benasayag, R., García-González, M. A., et al. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520903171276 · Cited by 55 · see citing works
Multi-omics analysis of fecal microbiota transplantation’s impact on functional constipation and comorbid depression and anxiety
Yang, C., Hu, T., Xue, X., Su, X., Zhang, X., Fan, Y., Shen, X., & Dong, X. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03123-1 · Cited by 53 · see citing works
Interplay between mast cells, enterochromaffin cells, and sensory signaling in the aging human bowel
Yu, Y., Daly, D., Adam, I. J., Kitsanta, P., Hill, C. J., Wild, J. R. L., Shorthouse, A. J., Grundy, D., & Jiang, W. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12842 · Cited by 51 · see citing works
Abnormal Small-Intestinal Endocrine Cells in Patients with Irritable Bowel Syndrome
El‐Salhy, M., Vaali, K., Dizdar, V., & Hausken, T. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-010-1169-6 · Cited by 50 · see citing works
5-HT7 receptor signaling: improved therapeutic strategy in gut disorders
Kim, J., & Khan, W. I. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00396 · Cited by 49 · see citing works
5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex
Niesler, B., Kapeller, J., Fell, C., Atkinson, W., Möller, D., Fischer, C., Whorwell, P. J., & Houghton, L. A. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832e9d6b · Cited by 48 · see citing works
The genetics of the serotonin transporter and irritable bowel syndrome
Colucci, R., Blandizzi, C., Bellini, M., Ghisu, N., Tonini, M., & Tacca, M. D. (2008) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2008.05.001 · Cited by 48 · see citing works
Gangliosides Protect Bowel in an Infant Model of Necrotizing Enterocolitis by Suppressing Proinflammatory Signals
Schnabl, K. L., Larsen, B. K., Aerde, J. E. V., Lees, G., Evans, M. L., Belosevic, M., Field, C. J., Thomson, A., & Clandinin, M. T. (2009) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181b6456d · Cited by 47 · see citing works
Serotonin, Inflammation, and IBS: Fitting the Jigsaw Together?
Spiller, R. E. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31812e66da · Cited by 44 · see citing works
Self-citation
TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut
Wang, H., Kwon, Y. H., Dewan, V., Vahedi, F., Syed, S. A., Fontes, M. E., Ashkar, A. A., Surette, M. G., & Khan, W. I. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801034 · Cited by 44 · see citing works
Effect ofLactobacillus rhamnosusGG supernatant on serotonin transporter expression in rats with post-infectious irritable bowel syndrome
Cao, Y.-N., Feng, L., Liu, Y.-Y., Jiang, K., Zhang, M.-J., Gu, Y., Wang, B., Gao, J., Wang, Z., & Wang, Y. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i3.338 · Cited by 44 · see citing works
Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium
Tsuruta, T., Saito, S., Osaki, Y., Hamada, A., AOKI-YOSHIDA, A., & Sonoyama, K. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.03.165 · Cited by 42 · see citing works
IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut
Manocha, M. M., Shajib, M. S., Rahman, M. M., Wang, H., Rengasamy, P., Bogunovic, M., Jordana, M., Mayer, L., & Khan, W. I. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.58 · Cited by 42 · see citing works
Interplay between Serotonin, Immune Response, and Intestinal Dysbiosis in Inflammatory Bowel Disease
Delgado, S. G., Veloz, I. G., Trejo-Vázquez, F., & Martínez‐Fierro, M. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415632 · Cited by 41 · see citing works
Th17: A New Participant in Gut Dysfunction in Mice Infected withTrichinella spiralis
Fu, Y., Wang, W., Tong, J., Pan, Q., Long, Y., Qian, W., & Hou, X. (2009) · Mediators of Inflammation · doi:10.1155/2009/517052 · Cited by 41 · see citing works
Irritable bowel syndrome: recent developments in diagnosis, pathophysiology, and treatment
El‐Salhy, M., Hatlebakk, J. G., Gilja, O. H., & Hausken, T. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.888952 · Cited by 39 · see citing works
5-Hydroxytryptophan activates colonic myenteric neurons and propulsive motor function through 5-HT4receptors in conscious mice
Wang, L., Martı́nez, V., Kimura, H., & Taché, Y. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00289.2006 · Cited by 39 · see citing works
Serotonin transporter gene promoter region polymorphisms and serotonin transporter expression in the colonic mucosa of irritable bowel syndrome patients
Wang, Y. M., Chang, Y., Chang, Y.-E., Cheng, J.-J., Li, J., Wang, T., Zhang, Q. Y., Liang, D. C., Sun, B., & Wang, B. M. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01902.x · Cited by 38 · see citing works
Characteristics of intestinal lamina propria dendritic cells in a mouse model of postinfectious irritable bowel syndrome
Long, Y., Wang, W., Wang, H., Hao, L., Qian, W., & Hou, X. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.07046.x · Cited by 36 · see citing works
5-HT7 receptor-dependent intestinal neurite outgrowth contributes to visceral hypersensitivity in irritable bowel syndrome
Chang, W.-Y., Yang, Y.-T., She, M., Tu, C., Lee, T., Wu, M., Sun, C., Hsin, L., & Yu, L. C. (2022) · Laboratory Investigation · doi:10.1038/s41374-022-00800-z · Cited by 37 · see citing works
Pathogenic Factors Involved in the Development of Irritable Bowel Syndrome: Focus on a Microbial Role
Bolino, C., & Berčík, P. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.07.005 · Cited by 34 · see citing works
2 Vagal control of gastrointestinal function
Grundy, D. (1988) · Baillière s Clinical Gastroenterology · doi:10.1016/0950-3528(88)90019-x · Cited by 34 · see citing works
Enterochromaffin Cell Hyperplasia in Irritable Pouch Syndrome
Shen, B., Liu, W. J., Remzi, F. H., Shao, Z., Lü, H., DeLaMotte, C., Hammel, J., Queener, E. Y., Bambrick, M. L., & Fazio, V. W. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01990.x · Cited by 33 · see citing works
Modulation of the immune response by helminths: a role for serotonin?
Wang, S., Sharkey, K. A., & McKay, D. M. (2018) · Bioscience Reports · doi:10.1042/bsr20180027 · Cited by 32 · see citing works
Molecular signalling during cross talk between gut brain axis regulation and progression of irritable bowel syndrome: A comprehensive review
Singh, S. V., Ganguly, R., Jaiswal, K., Yadav, A. K., Kumar, R., & Pandey, A. K. (2023) · World Journal of Clinical Cases · doi:10.12998/wjcc.v11.i19.4458 · Cited by 34 · see citing works
Changes of cytokine levels in a mouse model of post-infectious irritable bowel syndrome
Yang, B. K., Zhou, X., & Cheng, L. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0272-8 · Cited by 31 · see citing works

W1939 Endogenous Production of Hydrogen Sulfide Hyperpolarizes Circular Muscle Cells in the Mouse Colon
Sha, L., Linden, D. R., Farrugia, G., & Szurszewski, J. H. (2010) · Gastroenterology · doi:10.1016/s0016-5085(10)63552-4
W1937 Initiation and Propagation of Secondary Waves in the Canine Stomach In Vivo
Lammers, W. J. E. P., Donck, L. V., Stephen, B., Smets, D., & Schuurkes, J. A. J. (2010) · Gastroenterology · doi:10.1016/s0016-5085(10)63550-0 · Cited by 1 · see citing works
W1938 Antibody to Cytolethal Distending Toxin of Campylobacter Jejuni Stains Small Bowel Myenteric Neuromuscular Elements in Control and C. Jejuni Exposed Rats: A Possible Role of Molecular Mimicry
Sung, J. K., Morales, W., Weitsman, S. R., Pokkunuri, V. B., Guerry, P., Prouty, M. G., Conklin, J. L., Chang, C., & Pimentel, M. (2010) · Gastroenterology · doi:10.1016/s0016-5085(10)63551-2
Afferent hypersensitivity in a mouse model of post‐inflammatory gut dysfunction: role of altered serotonin metabolism
Keating, C. D., Beyak, M. J., Foley, S., Singh, G., Marsden, C. A., Spiller, R. E., & Grundy, D. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.156984 · Cited by 88 · see citing works
Self-citation
Involvement of Serotonin in Intestinal Mastocytopoiesis and Inflammation during a Trichinella spiralis Infection in Mice
Parmentier, H. K., de Vries, C., Ruitenberg, E. J., & Loveren, H. V. (2009) · International Archives of Allergy and Applied Immunology · doi:10.1159/000234327 · Cited by 14 · see citing works

Authors: Wheatcroft, J., Wakelin, D., Smith, A., Mahoney, C. R., Mawe, G., & Spiller, R.
Affiliations: University of Nottingham (GB)
University of Vermont (US)
Nottingham University Hospitals NHS Trust (GB)
Corresponding author: Spiller, R.
ORCID: Smith, A.
Mawe, G.
Spiller, R.
Venue: Neurogastroenterology & Motility
Publisher: Wiley
Published: 2005-11-18
Volume: 17
Issue: 6
Pages: 863-870
ISSN: 1350-1925 (ISSN-L)
1365-2982
DOI: 10.1111/j.1365-2982.2005.00719.x
OpenAlex: W1993725963
Cited by: 205
References: 30
Citations by year: 2026: 5 · 2025: 2 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 7 · 2017: 5 · 2016: 11 · 2015: 3 · 2014: 17 · 2013: 9 · 2012: 12
FWCI: 11.53
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Neurogastroenterology & Motility (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (DK62267, R01DK062267)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
Keywords: serotonin transporter, post-infectious irritable bowel syndrome, Trichinella spiralis infection, visceral hypersensitivity, gastrointestinal motility disorders, mastocytosis, T cell dependence, cortisol, intestinal inflammation
MeSH terms: Animals, Anti-Inflammatory Agents, Cell Count, Digestive System, Enterochromaffin Cells, Hydrocortisone, Hyperplasia, Immunohistochemistry, Intestinal Mucosa, Jejunum, Mast Cells, Mice, Inbred C57BL, T-Lymphocytes, Trichinellosis, Mice, Knockout, Serotonin Plasma Membrane Transport Proteins, Mice

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Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction

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