Development and evaluation of dexamethasone nanomicelles with potential for treating posterior uveitis after topical application
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PURPOSE: This study aims at the development and preliminary evaluation of dexamethasone nanomicelles for treating posterior uveitis. Nanomicelles were formulated using polyoxyl 40 stearate (P40S) and polysorbate 80 (P80), which are approved by the FDA for ocular use. METHODS: Dexamethasone nanomicelles were prepared and characterized for critical micellar concentration, solubility of dexamethasone, particle size, surface charge, morphology, in vitro drug release, clarity, stability, filtration efficiency, and sterility. Ocular tolerance and the tissue drug distribution of dexamethasone were assessed in rabbits after single and multiple topical administration. RESULTS: Dexamethasone nanomicelles (0.1% w/v) were successfully developed and characterized with an optimized composition of P40S/P80=7/3 by weight. The mean diameter of blank and drug-loaded nanomicelles was 13.3±0.4 and 14.5±0.4 nm, respectively. Transmission electron microscopy images revealed the spherical structure of nanomicelles. Nanomicelles were found to be stable with respect to clarity, size and drug content at 4°C and 25°C for up to 6 months. No irritation or redness was observed in the treated eyes as compared with the untreated control rabbit eyes. Therapeutic concentrations of dexamethasone were observed in the retina and choroid after single and multiple topical application in rabbits. CONCLUSION: In conclusion, the nanomicelles of P40S and P80 could efficiently solubilize 0.1% dexamethasone in their cores. The results also indicate that mixed nanomicelles could be utilized as a potential delivery system for delivering dexamethasone to treat the back of the eye diseases such as posterior uveitis after topical application.
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Patel et al. found therapeutic concentrations of DEX in choroid and retinal tissue after formulating DEX-loaded nanomicelles using P40S and P80, providing a non-invasive method for treating posterior segment uveitis.
“Therapeutic concentrations of DEX were detected in choroid and retinal tissue, providing a non-invasive method for treating posterior segment uveitis.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [14]
The Abstract and Conclusion report therapeutic dexamethasone concentrations in rabbit retina and choroid after topical application of P40S/P80 nanomicelles. The Conclusion calls this preliminary evidence for a proposed therapy; it does not establish the formulation as an effective treatment for posterior uveitis. (LLM, conf=0.86)
Experimental — accuracy not yet measuredHybrid nanomicelles composed of P40S and P80 (7:3) can efficiently load dexamethasone, improve solubility, promote transmembrane penetration and delivery in the posterior segment; after topical eye drops they achieve therapeutic concentration in retina-choroid, reduce vitreous exposure, and provide a non-invasive treatment for posterior uveitis.
“After topical eye drops, the system can achieve therapeutic concentration in the retina-choroid, effectively reduce drug exposure in the vitreous cavity, and provides a non-invasive treatment for posterior uveitis [41].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [41]
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“After topical eye drops, the system can achieve therapeutic concentration in the retina-choroid, effectively reduce drug exposure in the vitreous cavity, and provides a non-invasive treatment for posterior uveitis [41].”
- Authors
- Patel, S., Garapati, C., Chowdhury, P., Gupta, H., Nesamony, J., Nauli, S., & Boddu, S. H. S.
- Affiliations
- University of Toledo (US)
- Corresponding author
- Boddu, Sai H.S.
- Venue
- Journal of Ocular Pharmacology and Therapeutics
- Publisher
- SAGE Publications
- Published
- 2015-05
- Volume
- 31
- Issue
- 4
- Pages
- 215-227
- ISSN
- 1080-7683 (ISSN-L)
- 1557-7732
- PMC
- PMC11075078
- OpenAlex
- W1586893167
- Cited by
- 48
- References
- 32
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 3 · 2018: 5 · 2017: 6 · 2016: 2 · 2015: 3
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Ocular Pharmacology and Therapeutics (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Johnson and Johnson
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080640)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- dexamethasone, nanomicelles, posterior uveitis, topical ocular drug delivery, Tween 80, ocular tolerance, tissue drug distribution, drug solubilization, rabbit model
- MeSH terms
- Animals, Calorimetry, Differential Scanning, Dexamethasone, Glucocorticoids, Male, Micelles, Rabbits, Solubility, Uveitis, Posterior, Drug Delivery Systems, Microscopy, Electron, Transmission, Nanoparticles, Administration, Ophthalmic
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