Nanomicellar formulations for sustained drug delivery: strategies and underlying principles
Open accessAbstract
Micellar delivery systems smaller than 100 nm can be readily prepared. While micelles allow a great depth of tissue penetration for targeted drug delivery, they usually disintegrate rapidly in the body. Thus, sustained drug delivery from micellar nanocarriers is a challenge. This article summarizes various key strategies and underlying principles for sustained drug delivery using micellar nanocarriers. Comparisons are made with other competing delivery systems such as polymeric microparticles and nanoparticles. Amphiphilic molecules self-assemble in appropriate liquid media to form nanoscale micelles. Strategies for sustained release nanomicellar carriers include use of prodrugs, drug polymer conjugates, novel polymers with low critical micellar concentration or of a reverse thermoresponsive nature, reverse micelles, multi-layer micelles with layer by layer assembly, polymeric films capable of forming micelles in vivo and micelle coats on a solid support. These new micellar systems are promising for sustained drug delivery.
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Above the CMC, the equilibrium is dynamic and characterized by a continuous exchange of unimers between the micelle and the bulk phase.
“Above the CMC, the equilibrium is dynamic, and characterized by a continuous exchange of the unimers between the micelle and the bulk phase [32].”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [32]
The Abstract defines the CMC as the concentration above which surfactants form micelles, and says micelles can dissociate upon dilution. It does not describe a dynamic equilibrium or continuous exchange of unimers between micelles and the bulk phase; searches for those terms found no such passage. Page numbers were not available in our copy. (LLM, conf=0.78)
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- Authors
- Trivedi, R., & Kompella, U. B.
- Affiliations
- University of Colorado Denver (US)
- Corresponding author
- Kompella, Uday B
- ORCID
- Kompella, Uday B
- Venue
- Nanomedicine
- Publisher
- Informa UK Limited
- Published
- 2010-04
- Volume
- 5
- Issue
- 3
- Pages
- 485-505
- ISSN
- 1743-5889 (ISSN-L)
- 1748-6963
- PMC
- PMC2902878
- OpenAlex
- W2076663214
- Cited by
- 358
- References
- 56
- Citations by year
- 2026: 9 · 2025: 17 · 2024: 28 · 2023: 37 · 2022: 28 · 2021: 38 · 2020: 32 · 2019: 25 · 2018: 17 · 2017: 34 · 2016: 29 · 2015: 16 · 2014: 17 · 2013: 8 · 2012: 11
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nanomedicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (RC1EY020361, R24EY017045)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Chemistry › Organic Chemistry › Surfactants and Colloidal Systems
- Keywords
- nanomicelles, sustained drug release, amphiphile self-assembly, prodrugs, polymer-drug conjugates, reverse micelles, layer-by-layer assembly, polymer films, polymeric microparticles, nanoparticles, targeted drug delivery
- MeSH terms
- Animals, Humans, Micelles, Drug Delivery Systems, Nanotechnology, Nanostructures
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