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Sex and Gender Differences in Alzheimer's Disease: Recommendations for Future Research
Abstract
Alzheimer's disease (AD) disproportionately affects women in both prevalence and severity; however, the biologic mechanisms underlying these sex differences are not fully understood. Sex differences in the brain, such as in brain anatomy, age-related declines in brain volume, and brain glucose metabolism, have been documented and may be important in understanding AD etiology. The full impact of sex as a basic biologic variable on this neurodegenerative disease remains elusive. To address the evidence for sex differences in AD, the Society for Women's Health Research (SWHR) convened an interdisciplinary roundtable of experts from academia, clinical medicine, industry, and the government to discuss the state-of-the-science in sex and gender differences in AD. Roundtable participants were asked to address gaps in our knowledge and identify specific sex-based research questions for future areas of study.
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“It is unclear whether genetic risk operates differently in women and men in the development of, or susceptibility to, Alzheimer's pathology.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [310]
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West, R. K. (2016) · CUNY Academic Works (City University of New York) · Cited by 1
Investigating Tau pathology in an in vitro model for Alzheimer’s disease
Powrie, Y. S. L. (2016) · SUNScholar (Stellenbosch University) · Cited by 1
Mao, Y., Zhou, Y., Zhong, M., Lou, Y., Hua, Y., Wu, X., Wang, Y., Zou, H., Shi, J., Sheng, Y., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-7342255/v1 · Cited by 1
Fraser, L. M. (2013) · Library and Archives Canada (Government of Canada) · Cited by 1
Kumari, R., Bowen, C. A., Srivastava, U., Brandelli, A. D., Kumar, P., Kour, D., Malepati, S., Jang, W. E., Bromwich, M., Zeng, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.25.696456 · Cited by 2
ASSESSING MEMORY IN AN ALDEHYDE DEHYDROGENASE 2 KNOCKOUT MODEL OF ALZHEIMER'S DISEASE
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Metadata
- Authors
- Carter, C. L., Resnick, E. M., Mallampalli, M., & Kalbarczyk, A.
- Affiliations
- Society for Women's Health Research (US)
- Corresponding author
- Carter, Christine L.
- Venue
- Journal of Women's Health
- Publisher
- SAGE Publications
- Published
- 2012-10
- Volume
- 21
- Issue
- 10
- Pages
- 1018-1023
- ISSN
- 1059-7115 (ISSN-L)
- 1540-9996
- 1931-843X
- OpenAlex
- W2160236532
- Cited by
- 231
- References
- 35
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 22 · 2023: 19 · 2022: 20 · 2021: 19 · 2020: 21 · 2019: 23 · 2018: 18 · 2017: 12 · 2016: 23 · 2015: 11 · 2014: 10 · 2013: 8 · 2012: 1
- FWCI
- 6.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Women s Health (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, sex differences, gender differences, women's health, neuroanatomy, brain glucose metabolism, neurodegeneration, research priorities, sex as a biological variable
- MeSH terms
- Alzheimer Disease, Congresses as Topic, Female, Humans, Sex Characteristics, Sex Factors, Societies, Medical, Women's Health, Biomedical Research
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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