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Cited by 27LGBTQ Health, Identity, and PolicyDementia and Cognitive Impairment ResearchCancer-related cognitive impairment studies

Cognitive Impairment in Sexual and Gender Minority Groups: A Scoping Review of the Literature

Romanelli, Robert J., Rosenblatt, Andrew S., Marcum, Zachary A., Flatt, Jason D.·2024·LGBT Health
DOI 10.1089/lgbt.2023.0095
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Abstract

Purpose:The purpose of this review was to synthesize evidence on differences in cognitive impairment by sexual orientation/gender identity (SOGI) status. Methods:A scoping review of the literature was conducted. Five databases (PubMed/Medline, Cumulated Index to Nursing and Allied Health Literature, Web of Science, PsycInfo, and Embase) were searched for primary articles comparing incidence or prevalence of cognitive impairment among sexual and gender minority (SGM) groups versus non-SGM groups. Two reviewers independently screened articles and conducted risk-of-bias assessment on eligible articles. Results:Fifteen primary studies were eligible. Most studies (n = 13) were cross-sectional, with moderate to critical risk of bias. Among eight studies examining self-reported cognitive impairment, seven reported a higher prevalence among some SGM groups versus non-SGM groups. Among seven studies using objective measures of cognitive impairment, three examined prevalence of clinician-documented diagnosis of dementia, of which two reported a higher prevalence specifically among transgender versus cisgender individuals. Among the other four studies examining objective measures, two reported poorer cognitive performance or memory, one reported better performance, and another reported no difference. Comparisons across studies were challenging due to inconsistencies in how SOGI and cognitive impairment were operationalized, and the factors used for statistical adjustment; some studies adjusted for putative intermediary factors that potentially explain differences in cognitive impairment. Conclusions:Whereas most published studies identified a positive relationship between SOGI status and self-reported cognitive impairment, evidence is mixed with regard to objective cognitive performance. Well-designed longitudinal, observational studies are needed, using objective measures of cognitive function, with careful consideration of confounding versus intermediary risk factors.

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  • A recent review of the evidence found that most studies examining subjective cognitive decline as an outcome showed higher prevalence among SGM older adults, while those examining objective measures of cognitive performance showed more mixed results.

    “A recent review of the evidence found that most studies examining subjective cognitive decline as an outcome showed higher prevalence among SGM older adults, while those examining objective measures of cognitive performance showed more mixed results.”

    From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [356]

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Authors
Romanelli, R. J., Rosenblatt, A. S., Marcum, Z. A., & Flatt, J. D.
Affiliations
  • RAND Europe (GB)
  • Cedars-Sinai Medical Center (US)
  • University of Washington (US)
  • University of Nevada, Las Vegas (US)
Corresponding author
Romanelli, Robert J.
ORCID
Venue
LGBT Health
Publisher
SAGE Publications
Published
2024-04-01
Volume
11
Issue
3
Pages
178-192
ISSN
  • 2325-8292 (ISSN-L)
  • 2325-8306
DOI
10.1089/lgbt.2023.0095
OpenAlex
W4387568165
Cited by
27
References
41
Citations by year
2026: 8 · 2025: 9 · 2024: 9 · 2023: 1
FWCI
1.32
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • LGBT Health (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Social Psychology › LGBTQ Health, Identity, and Policy
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
cognitive impairment, sexual and gender minorities, sexual orientation, gender identity, transgender people, dementia, memory, prevalence, objective cognitive performance, confounding factors
MeSH terms
Sexual and Gender Minorities, Female, Gender Identity, Humans, Male, Sexual Behavior, Cognitive Dysfunction, Transgender Persons

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