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Cited by 29Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAcute Ischemic Stroke Management

Cholinergic modulation of cerebral cortical blood flow changes induced by trauma

SCREMIN, O.U., LI, M.G., JENDEN, D.J.·1997·Journal of Neurotrauma
DOI 10.1089/neu.1997.14.573
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Abstract

These experiments tested the role of cholinergic mechanisms in the changes of cerebral cortical blood flow (CBF) induced by brain trauma. CBF was measured with Iodo-14C-antipyrine autoradiography, in 128 cerebral cortex regions of both hemispheres, distributed in eight coronal slices. The effects of a 6.3-mm diameter craniotomy over the left motor-sensory cortex with no weight drop, and of trauma (drop weight of 20 g from 30 cm height on left motor-sensory cortex through a 6.3 mm circular craniotomy) on CBF were studied at 2 and 24 h after the interventions. A group of control animals that received no intervention was also set up. Animals were treated with the cholinesterase inhibitor physostigmine salicylate (3.3 microg/kg/min i.v. infusion started 60 min before CBF measurements), the cholinergic blocker scopolamine hydrobromide (1 mg/kg i.v. pulse, 18 min before CBF measurements), or with the drugs vehicle (saline). A focus of decreased CBF at the site of impact was observed 2 h after trauma, extending caudally as far as the occipital cortex. CBF on the contralateral cerebral cortex was also decreased. Both phenomena reversed partially at 24 h. This spontaneous recovery of CBF was blocked by scopolamine. Physostigmine reversed the decrease in CBF of the traumatized cortex, partially around the contused area and completely in more distant regions. The cerebral cortex contralateral to the trauma showed significantly higher CBF 24 h after trauma when compared to intact controls or craniotomy that peaked at the area symmetrical to the center of trauma. This phenomenon was also enhanced by physostigmine and completely blocked by scopolamine. These results suggest a prominent role of cholinergic mechanisms in the vascular adjustments that accompany cerebral trauma.

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Crossref · 10.1089/neu.1997.14.573

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  • The mechanisms by which cerebral ischemia occurs comprise morphological injury, hypotension in the presence of autoregulatory failure, inadequate availability of cholinergic neurotransmitters or nitric oxide, and potentiation of prostaglandin-induced vasoconstriction.

    “The mechanisms by which cerebral ischemia occurs comprise morphological injury, such as vessel distortion as a result of mechanical displacement, hypotension in the presence of autoregulatory failure, inadequate availability of cholinergic neurotransmitters or nitric oxide, and potentiation of prostaglandin-induced vasoconstriction (112-115).”

    From Pituitary Dysfunction After Traumatic Brain Injury: A Clinical and Pathophysiological Approach (2015) · cites this paper as [115]

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Authors
SCREMIN, O. U., LI, M. G., & JENDEN, D. J.
Affiliations
University of California, Los Angeles (US)
Venue
Journal of Neurotrauma
Publisher
SAGE Publications
Published
1997-08
Volume
14
Issue
8
Pages
573-586
ISSN
  • 0897-7151 (ISSN-L)
  • 1557-9042
DOI
10.1089/neu.1997.14.573
OpenAlex
W2062532500
Cited by
29
References
51
Citations by year
2025: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2015: 2 · 2012: 2
FWCI
1.42
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Journal of Neurotrauma (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
cerebral cortical blood flow, traumatic brain injury, cholinergic mechanisms, physostigmine, scopolamine, cholinesterase inhibition, cerebral vasodilation, bruising, craniotomy, weight-drop injury
MeSH terms
Animals, Autoradiography, Blood Gas Analysis, Blood Pressure, Body Temperature, Brain Injuries, Cerebrovascular Circulation, Cholinesterase Inhibitors, Hydrogen-Ion Concentration, Male, Parasympathetic Nervous System, Physostigmine, Scopolamine, Rats, Sprague-Dawley, Cholinergic Antagonists, Rats, In Vitro Techniques

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