The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Lateral Fluid Percussion Brain Injury: A 15-Year Review and Evaluation
Abstract
This article comprehensively reviews the lateral fluid percussion (LFP) model of traumatic brain injury (TBI) in small animal species with particular emphasis on its validity, clinical relevance and reliability. The LFP model, initially described in 1989, has become the most extensively utilized animal model of TBI (to date, 232 PubMed citations), producing both focal and diffuse (mixed) brain injury. Despite subtle variations in injury parameters between laboratories, universal findings are evident across studies, including histological, physiological, metabolic, and behavioral changes that serve to increase the reliability of the model. Moreover, demonstrable histological damage and severity-dependent behavioral deficits, which partially recover over time, validate LFP as a clinically-relevant model of human TBI. The LFP model, also has been used extensively to evaluate potential therapeutic interventions, including resuscitation, pharmacologic therapies, transplantation, and other neuroprotective and neuroregenerative strategies. Although a number of positive studies have identified promising therapies for moderate TBI, the predictive validity of the model may be compromised when findings are translated to severely injured patients. Recently, the clinical relevance of LFP has been enhanced by combining the injury with secondary insults, as well as broadening studies to incorporate issues of gender and age to better approximate the range of human TBI within study design. We conclude that the LFP brain injury model is an appropriate tool to study the cellular and mechanistic aspects of human TBI that cannot be addressed in the clinical setting, as well as for the development and characterization of novel therapeutic interventions. Continued translation of pre-clinical findings to human TBI will enhance the predictive validity of the LFP model, and allow novel neuroprotective and neuroregenerative treatment strategies developed in the laboratory to reach the appropriate TBI patients.
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Citations
Cites
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“Reciprocally, pre-clinical designs can be designed to include various dosing strategies, multiple severity levels within a single brain injury model, incorporating secondary insults evident in human TBI, or more than one model of TBI (Narayan et al., 2002).”
Self-citationPatient age and outcome following severe traumatic brain injury: an analysis of 5600 patients
Hukkelhoven, C. W. P. M., Steyerberg, E. W., Rampen, A. J. J., Farace, E., Habbema, J. D. F., Marshall, L. F., Murray, G. D., & Maas, A. I. R. (2003) · Journal of Neurosurgery · doi:10.3171/jns.2003.99.4.0666 · Cited by 641
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“The active, progressive enlargement of the cortical contusion and ventricles after LFP (Smith et al., 1997a; Bramlett et al., 1997b; Pierce et al., 1998) also parallels that seen after human head injury (Shiozaki et al., 2001).”
InfluentialSelf-citationSoares, H., Hicks, R., Smith, D., & McIntosh, T. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-12-08223.1995 · Cited by 379
Self-citationRecent advances in neurotrauma
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“…Conti et al., 1998; Pierce et al., 1998; Saatman et al., 1998; Carbonell et al., 1998; Sato et al., 2001; Raghupathi et al., 2003), medial septum (Sinson et al., 1997; Smith et al., 1997a), striatum (Hicks et al., 1996; Pierce et al., 1996; Hallam et al., 2004), and amygdala (Hallam et al., 2004).”
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Saatman, K. E., Contreras, P. C., Smith, D. H., Raghupathi, R., McDermott, K. L., Fernandez, S. C., Sanderson, K. L., Voddi, M., & McIntosh, T. K. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6629 · Cited by 185 · cited 3×
“The composite score of neuromotor function remains a reliable test to assess the level of neurological motor impairment from 48 hours to one year after LFP injury (Sun et al., 1995a; Saatman et al., 1997; Pierce et al., 1998; Knoblach et al., 2002a; Furukawa et al., 2003).”
Self-citationAdaptation of the fluid percussion injury model to the mouse
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“As such, the return of the righting reflex, and other reflexes, has served routinely as an indicator of severity of LFP injury (Morehead et al., 1994; Schmidt et al., 1995; Carbonell et al., 1998; Hallam et al., 2004; Lee et al., 2005), which appears to correlate with neuro-motor deficits.”
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“…to the pathology associated with LFP has been demonstrated at both acute and chronic time points throughout the brain (Cortez et al., 1989; Hill et al., 1996; Conti et al., 1998; Carbonell et al., 1999; D’Ambrosio et al., 1999; Hill-Felberg et al., 1999; Zhao et al., 2003; Grady et al., 2003).”
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Cited by
Classification of traumatic brain injury for targeted therapies
Saatman, K. E., Duhaime, A.-C., Bullock, R., Maas, A. I. R., Valadka, A., & Manley, G. T. (2008) · Journal of Neurotrauma · doi:10.1089/neu.2008.0586 · Cited by 1,141
Cernak, I. (2005) · NeuroRX · doi:10.1602/neurorx.2.3.410 · Cited by 462
Experimental models of traumatic brain injury: do we really need to build a better mousetrap?
Morales, D. M., Marklund, N., Lebold, D., Thompson, H. J., Pitkanen, A., Maxwell, W. L., Longhi, L., Laurer, H., Maegele, M., Neugebauer, E., et al. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.08.030 · Cited by 339
Self-citationPathogenesis of Brain Edema and Investigation into Anti-Edema Drugs
Michinaga, S., & Koyama, Y. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16059949 · Cited by 339
Gao, X., Deng, P., Xu, Z. C., & Chen, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024566 · Cited by 218
Metadata
- Authors
- Thompson, H. J., Lifshitz, J., Marklund, N., Grady, M. S., Graham, D. I., Hovda, D. A., & McIntosh, T. K.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2005-01
- Volume
- 22
- Issue
- 1
- Pages
- 42-75
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W1999934730
- Cited by
- 528
- References
- 17
- FWCI
- 14.12
- Type
- journal article
- Language
- en
- Open access
- closed
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