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Cited by 39Traumatic Brain Injury and Neurovascular DisturbancesMigraine and Headache StudiesTraumatic Brain Injury Research

Spreading depression following experimental head injury in the rat

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SUNAMI, Kenro, NAKAMURA, Takao, KUBOTA, Motoo, OZAWA, Yoshinori, NAMBA, Hiroki, YAMAURA, Akira, MAKINO, Hiroyasu·1989·Neurologia medico-chirurgica
DOI 10.2176/nmc.29.975
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Abstract

The direct current (DC) potential and electroencephalographic (EEG) changes were continuously monitored following fluid percussion head injury (brain contusion) in 10 conscious rats. Local cerebral glucose utilization (LCGU) was measured by the autoradiographic [14C]deoxyglucose method. Measurement of LCGU was started at the lowest point of the first or second DC potential negative shift when it occurred, and 2 hours after contusion if no DC potential changes were observed. The DC potential did not change in four rats (Group A), whereas DC potential negative shifts together with marked suppression of EEG activity occurred at 54 +/- 6.9 minutes after injury in six rats (Group B). In Group A, LCGU was decreased nonsignificantly in both the right and left cortices. In Group B, however, LCGU in the lesioned cortex rose to 160-190% of the level observed in the contralateral cortex (p less than 0.05). The autoradiographic pattern in Group B was identical to that seen in spreading depression. These findings can contribute to the effort to better understand the pathophysiology of head injury.

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  • In rodent models the primary insult usually results in spreading depolarization, but spontaneous spreading depolarizations are fewer with a shorter duration or do not occur.

    “In rodent models the primary insult usually results in spreading depolarization, but spontaneous spreading depolarizations are fewer with a shorter duration or do not occur (Sunami et al., 1989;Ozawa et al., 1991;Nilsson et al., 1993;Williams et al., 2005;von Baumgarten et al., 2008).”

    From Evolution of neuronal and astroglial disruption in the peri-contusional cortex of mice revealed by in vivo two-photon imaging (2013) · cites this paper as Sunami et al., 1989

    The Abstract reports spreading-depression-like shifts in six of ten injured rats and no DC-potential change in four. The Discussion says the first recorded shift occurred about 54 minutes after contusion, but recording did not begin immediately after impact; it also reports repeated shifts as often as 9–10 times per hour. The paper therefore supports the possibility of no observed later events, but does not establish that the primary insult usually caused spreading depolarization or that spontaneous events were fewer or shorter. (LLM, conf=0.85)

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Research works printed but not linked: 2

  1. [20]20. Miller JD, Becker DP: General principles and pathophysiology of head injury, in Youmans JR (ed): Neurological Surgery, vol 4. Philadelphia, WB Saunders, 1982, pp 1896-1937
  2. [23]23. Nedergaard M, Hansen AJ: Cortical spreading depression is elicited in focal ischemia. J Cereb Blood Flow Metab 7 [Suppl] 1: s118, 1987 30Nelson SR, Lowry OH, Passonneau JV: Changes in energy reserves in mouse brain associated with com pressive head injury, in Caveness WF, Walker AE (eds): Head Injury. Philadelphia, Lippincott, 1966, pp 444-447

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Authors
SUNAMI, K., NAKAMURA, T., KUBOTA, M., OZAWA, Y., NAMBA, H., YAMAURA, A., & MAKINO, H.
Affiliations
Chiba University (JP)
ORCID
Venue
Neurologia medico-chirurgica
Publisher
Japan Neurosurgical Society
Published
1989
Volume
29
Issue
11
Pages
975-980
ISSN
  • 0470-8105 (ISSN-L)
  • 1349-8029
DOI
10.2176/nmc.29.975
OpenAlex
W2066441511
Cited by
39
References
34
Citations by year
2026: 1 · 2023: 1 · 2020: 1 · 2019: 2 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
0.38
Type
journal article
Language
en
Open access
Locations
  • Neurologia medico-chirurgica (publishedVersion)
  • PubMed (publishedVersion)
Funders
Chiba University
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
cortical spreading depression, fluid percussion injury, cerebral contusion, traumatic brain injury, DC potential, local cerebral glucose utilization, brain energy metabolism, cortical lesions
MeSH terms
Animals, Brain Injuries, Deoxy Sugars, Deoxyglucose, Electroencephalography, Energy Metabolism, Male, Rats, Inbred Strains, Cortical Spreading Depression, Rats

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