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Cited by 393Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular DisturbancesLong-Term Effects of COVID-19

The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.

Systematic Review of Multivariable Prognostic Models for Mild Traumatic Brain Injury

Silverberg, Noah D., Gardner, Andrew J., Brubacher, Jeffrey R., Panenka, William J., Li, Jun Jian, Iverson, Grant L.·2015·Journal of Neurotrauma
DOI 10.1089/neu.2014.3600
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Abstract

Prognostic models can guide clinical management and increase statistical power in clinical trials. The availability and adequacy of prognostic models for mild traumatic brain injury (MTBI) is uncertain. The present study aimed to (1) identify and evaluate multivariable prognostic models for MTBI, and (2) determine which pre-, peri-, and early post-injury variables have independent prognostic value in the context of multivariable models. An electronic search of MEDLINE, PsycINFO, PubMed, EMBASE, and CINAHL databases for English-language MTBI cohort studies from 1970–2013 was supplemented by Web of Science citation and hand searching. This search strategy identified 7789 articles after removing duplicates. Of 182 full-text articles reviewed, 26 met eligibility criteria including (1) prospective inception cohort design, (2) prognostic information collected within 1 month post-injury, and (3) 2+variables combined to predict clinical outcome (e.g., post-concussion syndrome) at least 1 month later. Independent reviewers extracted sample characteristics, study design features, clinical outcome variables, predictor selection methods, and prognostic model discrimination, calibration, and cross-validation. These data elements were synthesized qualitatively. The present review found no multivariable prognostic model that adequately predicts individual patient outcomes from MTBI. Suboptimal methodology limits their reproducibility and clinical usefulness. The most robust prognostic factors in the context of multivariable models were pre-injury mental health and early post-injury neuropsychological functioning. Women and adults with early post-injury anxiety also have worse prognoses. Relative to these factors, the severity of MTBI had little long-term prognostic value. Future prognostic studies should consider a broad range of biopsychosocial predictors in large inception cohorts.

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Crossref · 10.1089/neu.2014.3600

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  1. Lingsma H., , Yue J.K., , Mass A., , Steyerberg E.W., , Manley G.T., , Cooper S.R., , Dams-O'Connor K., , Gordon W.A., , Menon D.K., , Mukherjee P., , Okonkwo D.O., , Puccio A.M., , Schnyer D.M., , Valadka A.B., , Vassar M.J., , and Yuh E.L. (2014). Outcome prediction after mild and complicated mild traumatic brain injury: external validation of existing models and identification of new predictors using the TRACK-TBI pilot study. J. Neurotrauma Epub ahead of print.

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Metadata

Authors
Silverberg, N. D., Gardner, A. J., Brubacher, J. R., Panenka, W. J., Li, J. J., & Iverson, G. L.
Affiliations
  • University of British Columbia (CA)
  • University of Newcastle Australia (AU)
  • Simon Fraser University (CA)
  • Harvard University (US)
Corresponding author
Silverberg, Noah D.
ORCID
Venue
Journal of Neurotrauma
Publisher
SAGE Publications
Published
2015-04
Volume
32
Issue
8
Pages
517-526
ISSN
  • 0897-7151 (ISSN-L)
  • 1557-9042
DOI
10.1089/neu.2014.3600
OpenAlex
W1974797523
Cited by
393
References
70
Citations by year
2026: 11 · 2025: 32 · 2024: 38 · 2023: 33 · 2022: 41 · 2021: 44 · 2020: 33 · 2019: 37 · 2018: 73 · 2017: 29 · 2016: 12 · 2015: 10
FWCI
2.27
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Neurotrauma (publishedVersion)
  • PubMed (publishedVersion)
  • NOVA (University of Newcastle Australia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
Keywords
mild traumatic brain injury, concussion, prognostic model, post-concussion syndrome, prognostic factors, neuropsychological performance, injury severity, discrimination and calibration
MeSH terms
Brain Injuries, Humans, Models, Neurological, Prognosis

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