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Cited by 44Growth Hormone and Insulin-like Growth FactorsTraumatic Brain Injury ResearchHormonal and reproductive studies

Functional Changes after Recombinant Human Growth Hormone Replacement in Patients with Chronic Traumatic Brain Injury and Abnormal Growth Hormone Secretion

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Mossberg, Kurt A., Durham, William J., Zgaljardic, Dennis J., Gilkison, Charles R., Danesi, Christopher P., Sheffield-Moore, Melinda, Masel, Brent E., Urban, Randall J.·2017·Journal of Neurotrauma
DOI 10.1089/neu.2016.4552PMC PMC5314981
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Abstract

We explored the effects of recombinant human growth hormone (rhGH) replacement on physical and cognitive functioning in subjects with a moderate-to-severe traumatic brain injury (TBI) with abnormal growth hormone (GH) secretion. Fifteen individuals who sustained a TBI at least 12 months prior to study enrollment were identified as having abnormal GH secretion by glucagon stimulation testing (maximum GH response less than 8 ng/mL). Peak cardiorespiratory capacity, body composition, and muscle force testing were assessed at baseline and one year after rhGH replacement. Additionally, standardized neuropsychological tests that assess memory, processing speed, and cognitive flexibility, as well as self-report inventories related to depression and fatigue, were administered at baseline and 1 year after rhGH replacement. Comparison tests were performed with proper post hoc analyses. All analyses were carried out at α < 0.05. Peak O 2 consumption, peak oxygen pulse (estimate of cardiac stroke volume), and peak ventilation all significantly increased ( p < 0.05). Maximal isometric and isokinetic force production were not altered. Skeletal muscle fatigue did not change but the perceptual rating of fatigue was reduced by ∼25% ( p = 0.06). Cognitive performance did not change significantly over time, whereas self-reported symptoms related to depression and fatigue significantly improved. The observed changes suggest that rhGH replacement has a positive impact on cardiorespiratory fitness and a positive impact on perceptual fatigue in survivors of TBI with altered GH secretion.

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  • PTHP is correlated with unfavorable metabolic and body composition profiles and lower quality of life scores.

    “Other studies have found a correlation between PTHP and unfavorable metabolic and body composition profiles with associated lower quality of life scores (28, 29)”

    From Post-Traumatic Hypopituitarism—Who Should Be Screened, When, and How? (2018) · cites this paper as [29]

    The Introduction (page unavailable) reports that a prior study found decreased quality of life in TBI patients with growth hormone deficiency and also describes reduced muscle mass in people with growth hormone deficiency. It does not establish the claimed correlation between post-traumatic hypopituitarism, unfavorable metabolic and body-composition profiles, and lower quality-of-life scores; this study assessed changes after growth hormone replacement without a GH-sufficient TBI comparison group. (LLM, conf=0.84)

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  1. [44]Delis D.C., Kaplan E., Kramer J., and Ober B.A. (2000). California Verbal Learning Test-Second Edition (CVLT-II) Manual. 2nd ed Psychological Corporation: San Antonio, TX [Google Scholar]
  2. [48]Astrand P.O., Rodahl K., Dahl H.A., and Stromme S.B. (2003). Textbook of Work Physiology: Physiological Basis of Exercise. 4th ed Human Kinetics: Champaign, IL [Google Scholar]

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Authors
Mossberg, K. A., Durham, W. J., Zgaljardic, D. J., Gilkison, C. R., Danesi, C. P., Sheffield-Moore, M., Masel, B. E., & Urban, R. J.
Affiliations
  • The University of Texas Medical Branch at Galveston (US)
  • Transitional Learning Center (US)
  • University of Texas Medical Branch
Corresponding author
Mossberg, Kurt A.
ORCID
Venue
Journal of Neurotrauma
Publisher
SAGE Publications
Published
2017-02
Volume
34
Issue
4
Pages
845-852
ISSN
  • 0897-7151 (ISSN-L)
  • 1557-9042
DOI
10.1089/neu.2016.4552
PMC
PMC5314981
OpenAlex
W2533220367
Cited by
44
References
57
Citations by year
2026: 3 · 2025: 1 · 2024: 7 · 2023: 3 · 2022: 5 · 2021: 8 · 2020: 4 · 2019: 8 · 2018: 3 · 2017: 2
FWCI
4.36
Type
journal article
Language
en
Open access
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Journal of Neurotrauma (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pfizer
  • National Institutes of Health (UL1TR001439)
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
recombinant human growth hormone, traumatic brain injury, growth hormone deficiency, glucagon stimulation test, cardiorespiratory fitness, oxygen consumption, body composition, muscle strength, skeletal muscle fatigue, perceptual fatigue, cognitive function, depression, neuropsychological outcomes
MeSH terms
Brain Injuries, Traumatic, Cardiorespiratory Fitness, Adult, Chronic Disease, Depression, Fatigue, Female, Humans, Male, Middle Aged, Recombinant Proteins, Outcome Assessment, Health Care, Human Growth Hormone, Hormone Replacement Therapy, Young Adult, Cognitive Dysfunction

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