Sports-Related Repetitive Traumatic Brain Injury: A Novel Cause of Pituitary Dysfunction
Abstract
Traumatic brain injury (TBI) is one of the major causes of disability and death, particularly in the young population. Recent clinical studies have demonstrated that TBI-induced pituitary dysfunction occurs more frequently than previously estimated, and this may contribute to delayed diagnosis and treatment of hormonal abnormalities. Today, the popularity of combative sports increases, and athletes who deal with these sports have risks of developing hypopituitarism attributed to repetitive TBIs. Pathogenesis and molecular mechanisms are not completely understood yet. Current studies suggest that athletes who had retired, especially from combative sports, should be screened for hypopituitarism. In this review, we aim to increase the awareness of medical communities, athletes, coaches, and athletic trainers about this issue by sharing the current studies regarding the pituitary dysfunction attributed to repetitive TBI associated with sports.
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Repetitive sports injury may place individuals at increased risk for pituitary deficiencies.
“with indications that even repetitive sports injury may place individuals at increased risk [27].”
From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [27]
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Neuroendocrine Disruptions Following Head Injury
Wexler, T. L. (2023) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-023-01263-5 · Cited by 23 · see citing works
- Authors
- Sezgin Caglar, A., Tanriverdi, F., Karaca, Z., Unluhizarci, K., & Kelestimur, F.
- Affiliations
- Department of Endocrinology and Metabolism, Erciyes University Medical School, Kayseri, Turkey.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2019-04-15
- Volume
- 36
- Issue
- 8
- Pages
- 1195-1202
- ISSN
- 0897-7151 (ISSN-L)
- 1557-9042
- OpenAlex
- W2904723799
- Cited by
- 14
- References
- 22
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 1 · 2020: 1 · 2019: 4
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurotrauma (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- repetitive traumatic brain injury, hypopituitarism, pituitary dysfunction, combat sports, athletes, endocrine disorders, screening, pathogenesis, molecular mechanisms
- MeSH terms
- Chronic Traumatic Encephalopathy, Athletic Injuries, Humans, Hypopituitarism
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