The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Alteration in Cerebral Activation during a Working Memory Task after Pediatric Mild Traumatic Brain Injury: A Prospective Controlled Cohort Study
Abstract
Mild traumatic brain injuries (mTBIs) commonly occur in children and adolescents and can result in persistent cognitive symptoms. The neurophysiological changes that underlie persistent post-concussive symptoms (PPCS) have not been characterized. Our objective was to compare working-memory related functional magnetic resonance imaging (fMRI) response in children with persistent symptoms after mTBI at one month post-injury to children with typical recovery and healthy controls. This was a prospective, controlled cohort study of children with mTBI at one month post-injury. PPCS was defined as children with a 10-point increase in their post-concussion symptom inventory score (compared with pre-injury score) at one month post-injury and a two-point increase in at least two symptom categories compared with pre-injury. One hundred and seven participants (60 PPCS, 30 recovered mTBI, and 17 controls) with a mean age of 14.2 years (standard deviation [SD] 2.5) (44% male) were assessed 38 (SD 5.9) days after mTBI. The primary outcome measures were visuospatial n-back working memory task performance and fMRI blood oxygen level dependent (BOLD) signal change. Children with PPCS had decreased activation relative to children with typical recovery in the posterior cingulate and precuneus during the one-back working memory condition, despite similar task performance. Differences in cortical activation in children with PPCS at one month highlight the persistent neurobiological consequences of pediatric mTBI on working memory cortical activation. These findings encourage recommendations to avoid contact sports and provide continued care at school for children with persistent symptoms at one month post-injury.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“(1) At one-month post-injury, the symptomatic mTBI (PPCS) group showed decreased brain activation compared to the asymptomatic (recovered) mTBI group during the 1-back working memory condition, specifically in the precuneus, posterior cingulate, and left Broca’s area (DLPFC ROI).”
From A systematic review of brain structural and functional alterations in pediatric mild traumatic brain injury (2026) · cites this paper as Khetani et al. (2019)
In the citing paper
“(2) No significant activation differences were found between either mTBI group and healthy controls.”
From A systematic review of brain structural and functional alterations in pediatric mild traumatic brain injury (2026) · cites this paper as Khetani et al. (2019)
In the citing paper
“In contrast, it was found that symptomatic children at one-month post-injury showed decreased activation in precuneus, posterior cingulate, and left Broca’s area during a 1-back task compared to asymptomatic peers, with no differences from healthy controls, suggesting that activation patterns vary by symptom status and time since injury (Khetani et al., 2019).”
From A systematic review of brain structural and functional alterations in pediatric mild traumatic brain injury (2026) · cites this paper as Khetani et al. (2019)
In the citing paper
“(4) The findings suggest that altered cortical activation, particularly greater default mode network inhibition and reduced task-positive network activation, may underlie persistent symptoms even in the absence of performance deficits.”
From A systematic review of brain structural and functional alterations in pediatric mild traumatic brain injury (2026) · cites this paper as Khetani et al. (2019)
In the citing paper
“(3) Despite the brain activation differences, all three groups (symptomatic, asymptomatic, controls) performed similarly on the working memory task (accuracy and reaction time).”
From A systematic review of brain structural and functional alterations in pediatric mild traumatic brain injury (2026) · cites this paper as Khetani et al. (2019)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
An analysis of variance test for normality (complete samples)
SHAPIRO, S. S., & WILK, M. B. (1965) · Biometrika · doi:10.1093/biomet/52.3-4.591 · Cited by 23,480
Position statement: definition of traumatic brain injury
Menon, D. K., Schwab, K., Wright, D. W., & Maas, A. I. (2010) · Archives of Physical Medicine and Rehabilitation · doi:10.1016/j.apmr.2010.05.017 · Cited by 1,678
Default-mode brain dysfunction in mental disorders: A systematic review
Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.002 · Cited by 1,675
Fransson, P., & Marrelec, G. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.05.059 · Cited by 1,213
Reliability and validity of a computerized neurocognitive test battery, CNS vital signs
GUALTIERI, C., & JOHNSON, L. (2006) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2006.05.007 · Cited by 873 · cited 1×
“41 This assessment consisted of seven tests: Verbal Memory, Visual Memory, Finger Tapping, Symbol Digit coding, Stroop test, Shifting Attention test, and the Continuous Performance test (age adjusted with a mean of 100 and SD of 15).”
Klingberg, T., Forssberg, H., & Westerberg, H. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902317205276 · Cited by 695
The molecular pathophysiology of concussive brain injury
Barkhoudarian, G., Hovda, D. A., & Giza, C. C. (2011) · Clinics in Sports Medicine · doi:10.1016/j.csm.2010.09.001 · Cited by 492
Holmes, J., Gathercole, S. E., Place, M., Dunning, D. L., Hilton, K. A., & Elliott, J. G. (2010) · Applied Cognitive Psychology · doi:10.1002/acp.1589 · Cited by 370
Cognitive and Behavioral Outcome Following Mild Traumatic Head Injury in Children
Ponsford, J., Willmott, C., Rothwell, A., Cameron, P., Ayton, G., Nelms, R., Curran, C., & Ng, K. T. (1999) · Journal of Head Trauma Rehabilitation · doi:10.1097/00001199-199908000-00005 · Cited by 299
Lovell, M. R., Pardini, J. E., Welling, J., Collins, M. W., Bakal, J., Lazar, N., Roush, R., Eddy, W. F., & Becker, J. T. (2007) · Neurosurgery · doi:10.1227/01.neu.0000279985.94168.7f · Cited by 197
Research works printed but not linked: 63
- 10.1097/00001199-200505000-00006 · DOI · Paper page
- 10.1080/02699050801888824 · DOI · Paper page
- 10.15620/cdc.5571 · DOI · Paper page
- 10.1542/peds.2009-0925 · DOI · Paper page
- 10.1177/0883073814543305 · DOI
- 10.1001/jamapediatrics.2016.2900 · DOI
- 10.1227/NEU.0000000000000505 · DOI · Paper page
- 10.1016/j.pmr.2011.08.002 · DOI
- 10.4085/1062-6050-48.4.05 · DOI · Paper page
- 10.1006/nimg.2001.0899 · DOI · Paper page
- 10.1089/neu.2006.23.1450 · DOI · Paper page
- 10.1016/j.clineuro.2012.12.038 · DOI
- 10.1146/annurev-psych-010814-015031 · DOI · Paper page
- 10.1080/21622965.2012.716752 · DOI
- 10.1002/hbm.21151 · DOI · Paper page
- 10.1080/87565641.2014.979926 · DOI
- 10.3109/17518420903087251 · DOI
- 10.1371/journal.pone.0126110 · DOI
- 10.1212/WNL.53.6.1300 · DOI · Paper page
- 10.1002/hbm.20709 · DOI
- 10.1136/jnnp.2006.110395 · DOI · Paper page
- 10.1016/j.neuroimage.2003.12.032 · DOI · Paper page
- 10.1007/s11682-015-9489-y · DOI
- 10.1227/NEU.0b013e3181ee33e2 · DOI
- 10.1089/neu.2010.1512 · DOI · Paper page
- 10.1017/S1355617711001226 · DOI · Paper page
- 10.1089/neu.2013.3052 · DOI
- 10.3233/PRM-150348 · DOI · Paper page
- 10.3109/02699052.2012.722259 · DOI
- 10.1212/WNL.0b013e31828d57dd · DOI · Paper page
- Janusz J.S. MS ; Gioia GA(2012). Postconcussion symptom assessment in: Mild Traumatic Brain Injury in Children and Adolescents vol. 1. Lorkwood M.W. and Yeates K.O. (eds).Guilford Press: New York. pps. 241–263.
- 10.1186/1745-6215-15-271 · DOI
- 10.1080/09297049.2010.533166 · DOI
- 10.1093/arclin/16.5.501 · DOI
- 10.1089/neu.2014.3356 · DOI
- 10.1080/09084280903526083 · DOI
- 10.1097/PEC.0000000000000959 · DOI
- 10.1089/neu.2013.2983 · DOI
- 10.3758/BF03207704 · DOI · Paper page
- 10.1016/j.neuroimage.2011.09.015 · DOI · Paper page
- 10.1006/nimg.1995.1012 · DOI · Paper page
- 10.1016/j.neuroimage.2008.10.065 · DOI · Paper page
- 10.1006/nimg.2001.0931 · DOI · Paper page
- 10.1097/00001756-200008030-00046 · DOI · Paper page
- 10.1016/S0896-6273(02)00817-6 · DOI · Paper page
- 10.1097/MOP.0b013e3283599a55 · DOI
- 10.1017/S1355617713000490 · DOI
- 10.1097/HTR.0b013e3181e5477c · DOI
- 10.1111/nyas.12360 · DOI · Paper page
- 10.1073/pnas.98.2.676 · DOI · Paper page
- 10.1073/pnas.0504136102 · DOI · Paper page
- 10.1089/neu.2014.3413 · DOI
- 10.1148/radiol.12120748 · DOI · Paper page
- 10.1016/j.neuroimage.2011.07.081 · DOI · Paper page
- 10.1007/s11682-012-9157-4 · DOI
- 10.3389/fneur.2018.00280 · DOI
- 10.1016/j.brainres.2013.08.034 · DOI
- 10.1089/neu.2012.2403 · DOI
- 10.3109/02699052.2013.793398 · DOI
- 10.1089/neu.2016.4868 · DOI
- 10.1136/bmjopen-2018-022098 · DOI
- 10.1111/dmcn.12263 · DOI
- 10.1136/bmjopen-2013-003550 · DOI
Cited by
Xu, H., Wu, S., Zhan, H., Xu, G., Zhao, J., & Yin, B. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1879109
Metadata
- Authors
- Khetani, A., Rohr, C. S., Sojoudi, A., Bray, S., & Barlow, K. M.
- Affiliations
- Department of Neuroscience and Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
- Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
- Biomedical Engineering, University of Calgary, Calgary, Alberta, Canada
- Faculty of Medicine, Child Health Research Centre, The University of Queensland, Queensland, Australia.
- Venue
- Journal of Neurotrauma
- Publisher
- SAGE Publications
- Published
- 2019-11-11
- Volume
- 36
- Issue
- 23
- Pages
- 3274-3283
- ISSN
- 0897-7151
- 1557-9042
- Cited by
- 29
- References
- 13
- Language
- en
- Licence
- journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
