Cited by 83Wound Healing and TreatmentsLaser Applications in Dentistry and MedicineDiabetic Foot Ulcer Assessment and Management

Gene Expression and Release of Growth Factors During Delayed Wound Healing: A Review of Studies in Diabetic Animals and Possible Combined Laser Phototherapy and Growth Factor Treatment to Enhance Healing

Peplow, Philip V., Baxter, G. David·2012·Photomedicine and Laser Surgery

Abstract

Objective: The purposes of this study were: to review studies of growth factors in cutaneous wounds of animals with diabetes to identify those factors with altered gene expression and content compared with nondiabetic animals; and to explore which deficiencies of growth factors in diabetic wounds may or may not be improved by laser irradiation. Background data: Wound healing is compromised in diabetes. Decreased production and/or increased destruction of growth factors may be responsible. Laser irradiation can increase the gene expression and release of certain growth factors by cells. Methods: Research articles investigating growth factor expression in wounds of nondiabetic and diabetic mice and rats published through September 2011 were retrieved from library sources, PubMed databases, reference lists of articles, and searches of relevant journals. Results: Vascular endothelial growth factor (VEGF), placental growth factor (PlGF), keratinocyte growth factor (KGF), fibroblast growth factor 1 (FGF-1), FGF-2, insulin-like growth factor 1 (IGF-1), IGF-2, transforming growth factor beta (TGF-β), and nerve growth factor (NGF) had decreased gene expression and content in early phases of healing for diabetic wounds. Gene expression of KGF, IGF-1, and IGF-2 was delayed, whereas that of FGF-1 and FGF-2 occurred earlier, in diabetic compared with nondiabetic wounds. Conclusions: Growth factor administration combined with laser irradiation may provide an effective therapy to maximize healing of diabetic wounds.

Integrity signals

Registry

Crossref · 10.1089/pho.2012.3312

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  • Treatment of rats, mice, and pigs with GHK effectively activates systemic healing throughout the animal.

    “The treatment of rats, mice, and pigs with GHK was shown to effectively activate systemic healing throughout the animal.”

    From GHK and DNA: Resetting the human genome to health (2014) · cites this paper as [39]

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Authors
Peplow, P. V., & Baxter, G. D.
Affiliations
  • University of Otago (NZ)
  • University of Otago
Corresponding author
Peplow, Philip V.
Venue
Photomedicine and Laser Surgery
Published
2012-11
Volume
30
Issue
11
Pages
617-636
ISSN
  • 1549-5418 (ISSN-L)
  • 1557-8550
OpenAlex
W1998044896
Cited by
83
References
50
Citations by year
2025: 5 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 11 · 2013: 4
FWCI
7.44
Type
journal article
Language
en
Open access
closed
Locations
  • Photomedicine and Laser Surgery (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Laser Applications in Dentistry and Medicine
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Keywords
diabetic wound healing, delayed wound healing, growth factors, gene expression, laser phototherapy, vascular endothelial growth factor, placental growth factor, keratinocyte growth factor, fibroblast growth factor, insulin-like growth factor, TGF-beta, nerve growth factor, skin wounds
MeSH terms
Animals, Diabetes Mellitus, Experimental, Wound Healing, Down-Regulation, Up-Regulation, Insulin-Like Growth Factor Binding Proteins, Low-Level Light Therapy, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factor A, Mice, Rats

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