Gene Expression and Release of Growth Factors During Delayed Wound Healing: A Review of Studies in Diabetic Animals and Possible Combined Laser Phototherapy and Growth Factor Treatment to Enhance Healing
Abstract
Objective: The purposes of this study were: to review studies of growth factors in cutaneous wounds of animals with diabetes to identify those factors with altered gene expression and content compared with nondiabetic animals; and to explore which deficiencies of growth factors in diabetic wounds may or may not be improved by laser irradiation. Background data: Wound healing is compromised in diabetes. Decreased production and/or increased destruction of growth factors may be responsible. Laser irradiation can increase the gene expression and release of certain growth factors by cells. Methods: Research articles investigating growth factor expression in wounds of nondiabetic and diabetic mice and rats published through September 2011 were retrieved from library sources, PubMed databases, reference lists of articles, and searches of relevant journals. Results: Vascular endothelial growth factor (VEGF), placental growth factor (PlGF), keratinocyte growth factor (KGF), fibroblast growth factor 1 (FGF-1), FGF-2, insulin-like growth factor 1 (IGF-1), IGF-2, transforming growth factor beta (TGF-β), and nerve growth factor (NGF) had decreased gene expression and content in early phases of healing for diabetic wounds. Gene expression of KGF, IGF-1, and IGF-2 was delayed, whereas that of FGF-1 and FGF-2 occurred earlier, in diabetic compared with nondiabetic wounds. Conclusions: Growth factor administration combined with laser irradiation may provide an effective therapy to maximize healing of diabetic wounds.
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Treatment of rats, mice, and pigs with GHK effectively activates systemic healing throughout the animal.
“The treatment of rats, mice, and pigs with GHK was shown to effectively activate systemic healing throughout the animal.”
From GHK and DNA: Resetting the human genome to health (2014) · cites this paper as [39]
Cites
Galiano, R. D., Tepper, O. M., Pelo, C. R., Bhatt, K. A., Callaghan, M. J., Bastidas, N., Bunting, S., Steinmetz, H., & Gurtner, G. C. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63754-6 · Cited by 801 · see citing works
Mechanisms of disease: metabolic effects of growth hormone and insulin-like growth factor 1
LeRoith, D., & Yakar, S. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0427 · Cited by 344 · see citing works
Hopkins, J. T., McLoda, T. A., Seegmiller, J. G., & Baxter, D. G. (2004) · PubMed Central · Cited by 322 · see citing works
Novel Insights into Wound Healing Sequence of Events
Braiman, L., Solomonik, I., Spira, R. M., & Tennenbaum, T. (2007) · Toxicologic Pathology · doi:10.1080/01926230701584189 · Cited by 308 · see citing works
Diabetes impairs the late inflammatory response to wound healing
Fahey, T. J., Sadaty, A., Jones, W. G., Barber, A. E., Smoller, B. R., & Shires, G. T. (1991) · Journal of Surgical Research · doi:10.1016/0022-4804(91)90196-s · Cited by 291 · see citing works
Werner, S., Breeden, M. P., Hübner, G., Greenhalgh, D. G., & Longaker, M. T. (1994) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12395564 · Cited by 282 · see citing works
Altavilla, D., Saitta, A., Cucinotta, D., Galeano, M., Deodato, B., Colonna, M. R., Torre, V., Russo, G. T., Sardella, A., Urna, G., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.3.667 · Cited by 273 · see citing works
Peplow, P. V., Chung, T., & Baxter, D. G. (2009) · Photomedicine and Laser Surgery · doi:10.1089/pho.2008.2446 · Cited by 225 · see citing works
Self-citationGrowth Factors Modulate Gonadotropin Receptor Induction in Granulosa Cell Cultures
Mondschein, J. S., & Schomberg, D. W. (1981) · Science · doi:10.1126/science.6258228 · Cited by 208 · see citing works
Bergeron, J., Frank, P. G., Scales, D. C., Meng, Q.-H., Castro, G. R., & Marcel, Y. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27429 · Cited by 187 · see citing works
Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse
Galeano, M., Bitto, A., Altavilla, D., Minutoli, L., Polito, F., Calò, M., Cascio, P. L., d’Alcontres, F. S., & Squadrito, F. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00361.x · Cited by 186 · see citing works
INHIBITION OF OVARIAN AND TESTICULAR STEROIODOGENESIS BY EPIDERMAL GROWTH FACTOR
Hsueh, A. J. W., Welsh, T. H., & Jones, P. (1981) · Endocrinology · doi:10.1210/endo-108-5-2002 · Cited by 183 · see citing works
PDGF and TGF-α Act Synergistically to Improve Wound Healing in the Genetically Diabetic Mouse
Brown, R. L., Breeden, M. P., & Greenhalgh, D. G. (1994) · Journal of Surgical Research · doi:10.1006/jsre.1994.1090 · Cited by 177 · see citing works
Galeano, M., Altavilla, D., Cucinotta, D., Russo, G. T., Calò, M., Bitto, A., Marini, H. R., Marini, R., Adamo, E. B., Seminara, P., et al. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2509 · Cited by 173 · see citing works
Safavi, S. M., Kazemi, B., Esmaeili, M., et al. (2007) · Lasers in Medical Science · doi:10.1007/s10103-007-0491-5 · Cited by 172 · see citing works
Liu, L., Marti, G. P., Wei, X., Zhang, X., Zhang, H., Liu, Y. V., Nastai, M., Semenza, G. L., & Harmon, J. W. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21503 · Cited by 162 · see citing works
Simvastatin enhances VEGF production and ameliorates impaired wound healing in experimental diabetes
Bitto, A., Minutoli, L., Altavilla, D., Polito, F., Fiumara, T., Marini, H. R., Galeano, M., Calò, M., Cascio, P. L., & Bonaiuto, M. (2008) · Pharmacological Research · doi:10.1016/j.phrs.2008.01.005 · Cited by 148 · see citing works
Knecht, M., & Catt, K. J. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)32787-x · Cited by 141 · see citing works
Bitar, M. S., & Labbad, Z. (1996) · Journal of Surgical Research · doi:10.1006/jsre.1996.0090 · Cited by 140 · see citing works
Graiani, G., Emanueli, C., Desortes, E., Linthout, S. V., Pinna, A., Figueroa, C. D., Manni, L., & Madeddu, P. (2004) · Diabetologia · doi:10.1007/s00125-004-1414-7 · Cited by 139 · see citing works
Komi-Kuramochi, A., Kawano, M., Oda, Y., Asada, M., Suzuki, M., Oki, J., & Imamura, T. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06055 · Cited by 138 · see citing works
Jones, P., Welsh, T. H., & Hsueh, A. J. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33752-9 · Cited by 136 · see citing works
Peplow, P. V., Chung, T., Ryan, B., et al. (2011) · Photomedicine and Laser Surgery · doi:10.1089/pho.2010.2846 · Cited by 129 · see citing works
Self-citationBrown, D. L., Kane, C. D., Chernausek, S. D., & Greenhalgh, D. G. (1997) · Europe PMC (PubMed Central) · Cited by 121 · see citing works
Boulware, S. D., Tamborlane, W. V., Rennert, N. J., Gesundheit, N., & Sherwin, R. S. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117065 · Cited by 121 · see citing works
Photobiomodulation Improves Cutaneous Wound Healing in an Animal Model of Type II Diabetes
Byrnes, K. R., Barna, L., Chenault, V. M., et al. (2004) · Photomedicine and Laser Surgery · doi:10.1089/pho.2004.22.281 · Cited by 111 · see citing works
Insulin-like growth factors I and II expression in the healing wound
Mh, G., Benson, J. D., & Caldwell, M. D. (1992) · Journal of Surgical Research · doi:10.1016/0022-4804(92)90121-f · Cited by 111 · see citing works
Rajasekaran, N. S., Nithya, M., Rose, C., & Chandra, T. S. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2004.03.004 · Cited by 108 · see citing works
Electroporative transfection with KGF-1 DNA improves wound healing in a diabetic mouse model
Marti, G. P., Ferguson, M. W. J., Wang, J., et al. (2004) · Gene Therapy · doi:10.1038/sj.gt.3302383 · Cited by 105 · see citing works
Placenta Growth Factor is Induced in Human Keratinocytes during Wound Healing
Failla, C. M., Odorisio, T., Cianfarani, F., Schietroma, C., Zambruno, G., & Puddu, P. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00085.x · Cited by 105 · see citing works
Oxygen Free Radicals and Wound Healing
White, M. J., & Heckler, F. R. (1990) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)30622-2 · Cited by 73 · see citing works
Yue, D. K., Swanson, B., McLennan, S. V., et al. (1986) · Diabetic Medicine · doi:10.1111/j.1464-5491.1986.tb00748.x · Cited by 69 · see citing works
Bitto, A., Minutoli, L., Galeano, M. R., et al. (2008) · Clinical Science · doi:10.1042/cs20070250 · Cited by 64 · see citing works
Synergistic actions of platelet‐derived growth factor and the insulin‐like growth factors in vivo
Greenhalgh, D. G., Hummel, R. P., Albertson, S., et al. (1993) · Wound Repair and Regeneration · doi:10.1046/j.1524-475x.1993.10206.x · Cited by 60 · see citing works
Tissue Factor as a Link Between Wounding and Tissue Repair
Chen, J., Kasper, M. E., Heck, T., Nakagawa, K., Humpert, P. M., Bai, L., Wu, G. Q., Zhang, Y., Luther, T., Andrassy, M., et al. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2143 · Cited by 59 · see citing works
Chesnoy, S., Lee, P.-Y., & Huang, L. (2003) · Pharmaceutical Research · doi:10.1023/a:1022635600479 · Cited by 53 · see citing works
Insulin and glucocorticoid-dependent suppression of the IGF-I system in diabetic wounds
Bitar, M. S. (2000) · Surgery · doi:10.1067/msy.2000.105869 · Cited by 53 · see citing works
Successful treatment of diabetic foot ulcers with low-level laser therapy
Kazemikhoo, N. (2006) · The Foot · doi:10.1016/j.foot.2006.05.004 · Cited by 49 · see citing works
Stallmeyer, B., Pfeilschifter, J. M., & Frank, S. (2001) · Diabetologia · doi:10.1007/s001250051645 · Cited by 48 · see citing works
Moulin, V. J., Lawny, F., Barritault, D., & Caruelle, J. (1998) · PubMed · Cited by 48 · see citing works
Growth factors bFGF and TGB beta accelerate the rate of wound repair in normal and in diabetic rats.
Broadley, K. N., Aquino, A. M., Hicks, B., et al. (1988) · PubMed · Cited by 47 · see citing works
Xie, L., Zhang, M., Dong, B., et al. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.05.016 · Cited by 42 · see citing works
Chung, T., Peplow, P. V., & Baxter, D. G. (2010) · Lasers in Surgery and Medicine · doi:10.1002/lsm.20981 · Cited by 30 · see citing works
Self-citationChung, T., Peplow, P. V., & Baxter, D. G. (2009) · Photomedicine and Laser Surgery · doi:10.1089/pho.2009.2493 · Cited by 29 · see citing works
Self-citationEstrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor
Ashcroft, G. S., Mills, S. J., Lei, K.-J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200316288 · Cited by 29 · see citing works
Vascular endothelial growth factor expression in rat skin incision wound
Nogami, M., Hoshi, T., Kinoshita, M., et al. (2007) · Medical Molecular Morphology · doi:10.1007/s00795-007-0357-8 · Cited by 28 · see citing works
LOW LEVEL LASER THERAPY IN PATIENTS WITH VENOUS ULCERS:
Kleinman, Y., Simmer, S., Braksma, Y., et al. (1996) · LASER THERAPY · doi:10.5978/islsm.8.205 · Cited by 26 · see citing works
MACROPHAGE RESPONSIVENESS TO LASER THERAPY WITH VARYING PULSING FREQUENCIES
Rajaratnam, S. S., Bolton, P. A., & Dyson, M. (1994) · LASER THERAPY · doi:10.5978/islsm.94-or-04 · Cited by 25 · see citing works
Modulation of calprotectin in human keratinocytes by keratinocyte growth factor and interleukin‐1α
Bando, M., Hiroshima, Y., Kataoka, M., et al. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2009.104 · Cited by 23 · see citing works
Zubaidi, A. M., Buie, W. D., Hart, D. A., & Sigalet, D. L. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0931-0 · Cited by 18 · see citing works
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GHK and DNA: Resetting the human genome to health
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2014) · BioMed Research International · doi:10.1155/2014/151479 · Cited by 39 · see citing works
- Authors
- Peplow, P. V., & Baxter, G. D.
- Affiliations
- University of Otago (NZ)
- University of Otago
- Corresponding author
- Peplow, Philip V.
- ORCID
- Peplow, Philip V.
- Venue
- Photomedicine and Laser Surgery
- Publisher
- SAGE Publications
- Published
- 2012-11
- Volume
- 30
- Issue
- 11
- Pages
- 617-636
- ISSN
- 1549-5418 (ISSN-L)
- 1557-8550
- OpenAlex
- W1998044896
- Cited by
- 83
- References
- 50
- Citations by year
- 2025: 5 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 6 · 2018: 9 · 2017: 6 · 2016: 5 · 2015: 7 · 2014: 11 · 2013: 4
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photomedicine and Laser Surgery (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Laser Applications in Dentistry and Medicine
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
- Keywords
- diabetic wound healing, delayed wound healing, growth factors, gene expression, laser phototherapy, vascular endothelial growth factor, placental growth factor, keratinocyte growth factor, fibroblast growth factor, insulin-like growth factor, TGF-beta, nerve growth factor, skin wounds
- MeSH terms
- Animals, Diabetes Mellitus, Experimental, Wound Healing, Down-Regulation, Up-Regulation, Insulin-Like Growth Factor Binding Proteins, Low-Level Light Therapy, Intercellular Signaling Peptides and Proteins, Vascular Endothelial Growth Factor A, Mice, Rats
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