Carnisone Increases Efficiency of DOPA Therapy of Parkinson's Disease: A Pilot Study
Abstract
The addition of the neuropeptide carnosine ( β -alanyl-L-histidine) as a food additive to the basic protocol of Parkinson's disease treatment results in significant improvement of neurological symptoms, along with increase in red blood cell Cu/Zn-SOD and decrease in blood plasma protein carbonyls and lipid hydroperoxides, with no noticeable change in platelets MAO B activity. The combination of carnosine with basic therapy may be a useful way to increase efficiency of PD treatment.
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Parkinson's patients with trembling manifestations taking Levodopa and dopamine-receptor agonists plus oral carnosine showed enhanced efficiency of basic therapy, manifested by restored levels of superoxide dismutase.
“Parkinson’s patients with trembling manifestations taking basic treatment with Levodopa and dopamine-receptor agonists plus oral carnosine supplementation showed enhanced efficiency of basic therapy against PD, manifested by restored levels of superoxide dismutase, typically lowered in patients (Boldyrev et al. 2008).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Boldyrev et al. 2008
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- Authors
- Boldyrev, A., Fedorova, T., Stepanova, M., Dobrotvorskaya, I., Kozlova, E., Boldanova, N., Bagyeva, G., Ivanova-Smolenskaya, I., & Illarioshkin, S.
- Affiliations
- Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia.
- Research Center of Neurology (RU)
- Russian Academy of Sciences (RU)
- ORCID
- Stepanova, Maria
- Venue
- Rejuvenation Research
- Publisher
- SAGE Publications
- Published
- 2008-08
- Volume
- 11
- Issue
- 4
- Pages
- 821-827
- ISSN
- 1094-5458 (ISSN-L)
- 1549-1684
- 1557-8577
- OpenAlex
- W1978715967
- Cited by
- 123
- References
- 29
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 5 · 2023: 10 · 2022: 5 · 2021: 13 · 2020: 10 · 2019: 8 · 2018: 11 · 2017: 6 · 2016: 14 · 2015: 6 · 2014: 7 · 2013: 6 · 2012: 4
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Rejuvenation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Medical Sciences
- Russian Academy of Sciences
- Topics
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Coenzyme Q10 studies and effects
- Keywords
- carnosine, Parkinson's disease, combination therapy, copper-zinc superoxide dismutase, protein carbonyls, lipid hydroperoxides, oxidative stress, neuroprotection
- MeSH terms
- Adult, Aged, Carnosine, Dihydroxyphenylalanine, Drug Synergism, Female, Humans, Male, Middle Aged, Monoamine Oxidase, Parkinson Disease, Pilot Projects, Superoxide Dismutase, Treatment Outcome, Oxidative Stress, Protein Carbonylation
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