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Cited by 339Wound Healing and TreatmentsMesenchymal stem cell researchDiabetic Foot Ulcer Assessment and Management

Targeting Nonhealing Ulcers of Lower Extremity in Human Through Autologous Bone Marrow-Derived Mesenchymal Stem Cells

Dash, Nihar Ranjan, Dash, Surjya Narayan, Routray, Padmanav, Mohapatra, Sribatsha, Mohapatra, Prakash C.·2009·Rejuvenation Research
DOI 10.1089/rej.2009.0872
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Abstract

Bone marrow (BM)-derived mesenchymal stem cells (MSCs) represent a promising population for supporting new concepts in cellular therapy. This study was undertaken to assess the efficacy and feasibility of autologous BM-derived MSCs in the treatment of chronic nonhealing ulcers (diabetic foot ulcers and Buerger disease) of the lower extremities. A total of 24 patients with nonhealing ulcers of the lower limb were enrolled and randomized into implant and control groups. In the implant group, the patients received autologous cultured BM-derived MSCs along with standard wound dressing; the control group received only the standard wound dressing regimen, followed up for at least a 12-week period. Wound size, pain-free walking distance, and biochemical parameters were measured before therapy and at every 2-week interval following intervention. The implant group had significant improvement in pain-free walking distance and reduction in ulcer size as compared to those in the control group. In the implant group for Buerger disease, the ulcer area decreased from 5.04 ± 0.70 cm 2 to 1.48 ± 0.56 cm 2 ( p < 0.001), whereas the pain-free walking distance increased from 38.33 ± 17.68 m to 284.44 ± 212.12 m ( p < 0.001). In the diabetic foot ulcer group, the ulcer size decreased from 7.26 ± 1.41 cm 2 to 2 ± 0.98 cm 2 ( p < 0.001) at 12 weeks. Mononuclear cells were cultured for a minimum of five passages and characterized by cell-surface markers showing CD90 + , CD105 + , and CD34 − . There was no significant alteration in the biochemical parameters observed during the follow-up period, indicating normal liver and renal function following intervention. Biopsy microsection of implanted tissues showed development of dermal cells (mainly fibroblasts), including mature and immature inflammatory cells. The study indicates that autologous implantation of BM-derived MSCs in nonhealing ulcers accelerates the healing process and improves clinical parameters significantly.

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  • Clinical studies have shown that bone marrow- and adipose tissue-derived MSCs can augment repair when applied locally to chronic skin wounds in patients.

    “Along these lines, clinical studies have shown that bone marrow– and adipose tissue–derived MSCs can augment the repair process when applied locally to chronic skin wounds in patients (96, 150).”

    From Wound repair and regeneration: Mechanisms, signaling, and translation (2014) · cites this paper as [150]

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Authors
Dash, N. R., Dash, S. N., Routray, P., Mohapatra, S., & Mohapatra, P. C.
Affiliations
  • Sriram Chandra Bhanja Medical College Hospital (IN)
  • Central Institute of Freshwater Aquaculture (IN)
Corresponding author
Mohapatra, Prakash C.
ORCID
Venue
Rejuvenation Research
Publisher
SAGE Publications
Published
2009-10
Volume
12
Issue
5
Pages
359-366
ISSN
  • 1094-5458 (ISSN-L)
  • 1549-1684
  • 1557-8577
DOI
10.1089/rej.2009.0872
OpenAlex
W2018862422
Cited by
339
References
30
Citations by year
2026: 11 · 2025: 11 · 2024: 19 · 2023: 23 · 2022: 35 · 2021: 19 · 2020: 21 · 2019: 17 · 2018: 33 · 2017: 25 · 2016: 20 · 2015: 19 · 2014: 14 · 2013: 27 · 2012: 26
FWCI
15.28
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Rejuvenation Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Keywords
mesenchymal stem cells, bone marrow-derived stem cells, autologous cell therapy, chronic non-healing ulcers, diabetic foot ulcer, thromboangiitis obliterans, leg ulcers, wound healing, pain-free walking distance, stem cell transplantation, cell surface markers
MeSH terms
Adult, Biopsy, Humans, Inflammation, Leg, Male, Pain, Thromboangiitis Obliterans, Time Factors, Ulcer, Wound Healing, Foot Ulcer, Treatment Outcome, Lower Extremity, Mesenchymal Stem Cell Transplantation

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