Role of ligands of receptor for advanced glycation end products (RAGE) in peripheral artery disease
Abstract
Atherosclerotic cardiovascular disease, including peripheral artery disease (PAD), is more common and severe in diabetic patients compared with nondiabetic individuals. Indeed, diabetes is associated with the increased risk of limb amputation and all-cause mortality in patients with symptomatic PAD. Proteins and lipids are nonenzymatically modified by sugars, resulting in the formation and accumulation of advanced glycation end products (AGEs), whose process is accelerated under diabetic conditions, especially patients with a long duration of diabetes. Accumulating evidence shows that nonenzymatic modification by sugars alters the structural integrity of collagens and lipoproteins in large vessels, thereby being involved in vascular stiffness and atherosclerotic plaque instability. Furthermore, engagement of receptor for AGEs (RAGE) with its ligands, such as AGEs, high mobility group box 1, and S100A proteins evokes inflammatory and thrombotic reactions, thus playing a central role in the development and progression of atherosclerotic cardiovascular disease. In this article, we review the pathophysiological role of RAGE ligands in PAD and discuss the clinical utility of measurement of plasma, serum, or tissue RAGE ligands for assessment of the severity and prognosis of PAD. This review suggests that RAGE ligands may be a novel biomarker and also a therapeutic target of PAD, especially in patients with diabetes.
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Zealley, B., & de Grey, A. D. N. J. (2019) · Rejuvenation Research · doi:10.1089/rej.2019.2201 · Cited by 3 · see citing works
Commentary on Some Recent Theses Relevant to Combating Aging: August 2019
Zealley, B., & de Grey, A. D. N. J. (2019) · Rejuvenation Research · doi:10.1089/rej.2019.2248 · Cited by 3 · see citing works
Commentary on Some Recent Theses Relevant to Combating Aging: October 2019
Zealley, B., & de Grey, A. D. N. J. (2019) · Rejuvenation Research · doi:10.1089/rej.2019.2270 · Cited by 3 · see citing works
Commentary on Some Recent Theses Relevant to Combating Aging: December 2019
Zealley, B., & de Grey, A. D. N. J. (2019) · Rejuvenation Research · doi:10.1089/rej.2019.2286 · Cited by 3 · see citing works
Commentary on Some Recent Theses Relevant to Combating Aging: April 2020
Zealley, B., & de Grey, A. D. N. J. (2020) · Rejuvenation Research · doi:10.1089/rej.2020.2334
Commentary on Some Recent Theses Relevant to Combating Aging: June 2020
Zealley, B., & de Grey, A. D. N. J. (2020) · Rejuvenation Research · doi:10.1089/rej.2020.2358
Koroleva, E. A., & Romanov, V. V. (2024) · International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON) · doi:10.1109/sibircon63777.2024.10758526
Receptor for Advanced Glycation End Products in Cardiovascular and Diabetic Complication(s)
Rani, R., Malik, P., & Mukherjee, T. K. (2025) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815322521125010010
Abolfazli, S., Atkin, S. L., Jamialahmadi, T., & Sahebkar, A. (2025) · Glycoconjugate Journal · doi:10.1007/s10719-025-10197-8 · Cited by 1 · see citing works
Advanced Glycation End Products— Physiology and Pathological Activity: A Literature Review
Ali, S. H., & Mhaibes, S. H. (2026) · Al-Rafidain Journal of Medical Sciences · doi:10.54133/ajms.v10i1.2593
Biochemical pathways and regulation of metabolic memory
Gupta, J. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44591-0.00002-3
- Authors
- Yamagishi, S.-I., & Matsui, T.
- Affiliations
- Kurume University (JP)
- Corresponding author
- Yamagishi, Sho-ichi
- Venue
- Rejuvenation Research
- Publisher
- SAGE Publications
- Published
- 2018-10
- Volume
- 21
- Issue
- 5
- Pages
- 456-463
- ISSN
- 1094-5458 (ISSN-L)
- 1549-1684
- 1557-8577
- OpenAlex
- W2797611094
- Cited by
- 31
- References
- 74
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 8 · 2018: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Rejuvenation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (16K07101, 17K08968)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
- Health Sciences › Medicine › Dermatology › Skin Diseases and Diabetes
- Keywords
- receptor for advanced glycation end products, RAGE ligands, advanced glycation end products, peripheral arterial disease, diabetes mellitus, high mobility group box 1, atherosclerosis, vascular stiffness, inflammation, thrombosis, biomarkers, therapeutic target
- MeSH terms
- Receptor for Advanced Glycation End Products, Animals, Humans, Ligands, Oxidative Stress, Disease Progression, Peripheral Arterial Disease
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