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Cited by 38Mesenchymal stem cell researchPluripotent Stem Cells ResearchPeriodontal Regeneration and Treatments

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Genetic Engineering of Mesenchymal Stem Cells for Regenerative Medicine

Nowakowski, Adam, Walczak, Piotr, Janowski, Miroslaw, Lukomska, Barbara·2015·Stem Cells and Development
DOI 10.1089/scd.2015.0062
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Abstract

Mesenchymal stem cells (MSCs), which can be obtained from various organs and easily propagated in vitro, are one of the most extensively used types of stem cells and have been shown to be efficacious in a broad set of diseases. The unique and highly desirable properties of MSCs include high migratory capacities toward injured areas, immunomodulatory features, and the natural ability to differentiate into connective tissue phenotypes. These phenotypes include bone and cartilage, and these properties predispose MSCs to be therapeutically useful. In addition, MSCs elicit their therapeutic effects by paracrine actions, in which the metabolism of target tissues is modulated. Genetic engineering methods can greatly amplify these properties and broaden the therapeutic capabilities of MSCs, including transdifferentiation toward diverse cell lineages. However, cell engineering can also affect safety and increase the cost of therapy based on MSCs; thus, the advantages and disadvantages of these procedures should be discussed. In this review, the latest applications of genetic engineering methods for MSCs with regenerative medicine purposes are presented.

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Metadata

Authors
Nowakowski, A., Walczak, P., Janowski, M., & Lukomska, B.
Affiliations
  • Mossakowski Medical Research Institute, Polish Academy of Sciences (PL)
  • Johns Hopkins University (US)
  • Polish Academy of Sciences
Corresponding author
Nowakowski, Adam
ORCID
Venue
Stem Cells and Development
Publisher
SAGE Publications
Published
2015-07-03
Volume
24
Issue
19
Pages
2219-2242
ISSN
  • 1525-8165 (ISSN-L)
  • 1547-3287
  • 1557-8534
DOI
10.1089/scd.2015.0062
OpenAlex
W1944852218
Cited by
38
References
5
Citations by year
2026: 2 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 8 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 7
FWCI
0.66
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Stem Cells and Development (publishedVersion)
  • PubMed (publishedVersion)
Funders
Narodowe Centrum Badań i Rozwoju
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords
mesenchymal stem cells, genetic engineering, regenerative medicine, transdifferentiation, immunomodulation, paracrine signaling, cell therapy safety
MeSH terms
Cell Differentiation, Genetic Engineering, Humans, Cytokines, Outcome Assessment, Health Care, Inflammation Mediators, Transgenes, Tissue Engineering, Regenerative Medicine, Mesenchymal Stem Cells

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