The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Connecting Mitochondria, Metabolism, and Stem Cell Fate
Open accessAbstract
As sites of cellular respiration and energy production, mitochondria play a central role in cell metabolism. Cell differentiation is associated with an increase in mitochondrial content and activity and with a metabolic shift toward increased oxidative phosphorylation activity. The opposite occurs during reprogramming of somatic cells into induced pluripotent stem cells. Studies have provided evidence of mitochondrial and metabolic changes during the differentiation of both embryonic and somatic (or adult) stem cells (SSCs), such as hematopoietic stem cells, mesenchymal stem cells, and tissue-specific progenitor cells. We thus propose to consider those mitochondrial and metabolic changes as hallmarks of differentiation processes. We review how mitochondrial biogenesis, dynamics, and function are directly involved in embryonic and SSC differentiation and how metabolic and sensing pathways connect mitochondria and metabolism with cell fate and pluripotency. Understanding the basis of the crosstalk between mitochondria and cell fate is of critical importance, given the promising application of stem cells in regenerative medicine. In addition to the development of novel strategies to improve the in vitro lineage-directed differentiation of stem cells, understanding the molecular basis of this interplay could lead to the identification of novel targets to improve the treatment of degenerative diseases.
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Cites
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BackgroundNaive and Primed Pluripotent States
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The role of mitochondrial ROS in the aging brain
Stefanatos, R., & Sanz, A. (2018) · FEBS Letters · doi:10.1002/1873-3468.12902 · Cited by 358
Single-cell entropy for accurate estimation of differentiation potency from a cell’s transcriptome
Teschendorff, A. E., & Enver, T. (2017) · Nature Communications · doi:10.1038/ncomms15599 · Cited by 346
Yan, W., Diao, S., & Fan, Z. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02194-z · Cited by 167
Regulation of Adult Neurogenesis in Mammalian Brain
Niklison-Chirou, M. V., Agostini, M., Amelio, I., & Melino, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144869 · Cited by 143
Correia, C., Koshkin, A., Duarte, P., Hu, D., Carido, M., Sebastião, M. J., Gomes‐Alves, P., Elliott, D. A., Domian, I. J., Teixeira, A. P., et al. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26504 · Cited by 139
Metadata
- Authors
- Wanet, A., Arnould, T., Najimi, M., & Renard, P.
- Venue
- Stem Cells and Development
- Publisher
- SAGE Publications
- Published
- 2015-09
- Volume
- 24
- Issue
- 17
- Pages
- 1957-1971
- ISSN
- 1525-8165 (ISSN-L)
- 1547-3287
- 1557-8534
- OpenAlex
- W2290909023
- Cited by
- 313
- References
- 135
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
