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Cited by 167Mesenchymal stem cell researchMitochondrial Function and PathologyAdipose Tissue and Metabolism

The role and mechanism of mitochondrial functions and energy metabolism in the function regulation of the mesenchymal stem cells

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Yan, Wanhao, Diao, Shu, Fan, Zhipeng·2021·Stem Cell Research & Therapy
DOI 10.1186/s13287-021-02194-zPMC PMC7890860
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Abstract

Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-directional differentiation, and paracrine and immune regulation. As a result of these properties, the MSCs have great clinical application prospects, especially in the regeneration of injured tissues, functional reconstruction, and cell therapy. However, the transplanted MSCs are prone to ageing and apoptosis and have a difficult to control direction differentiation. Therefore, it is necessary to effectively regulate the functions of the MSCs to promote their desired effects. In recent years, it has been found that mitochondria, the main organelles responsible for energy metabolism and adenosine triphosphate production in cells, play a key role in regulating different functions of the MSCs through various mechanisms. Thus, mitochondria could act as effective targets for regulating and promoting the functions of the MSCs. In this review, we discuss the research status and current understanding of the role and mechanism of mitochondrial energy metabolism, morphology, transfer modes, and dynamics on MSC functions.

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  • MSC mitochondrial metabolism is linked to secretion of trophic factors and intercellular communication, in turn impacting function in other cells.

    “This is consistent with reports that MSC mitochondrial metabolism is linked to secretion of trophic factors and intercellular communication, in turn impacting function in other cells (Yan et al., 2021; Wang et al., 2025).”

    From APOE3-Christchurch variant enhances neurovascular support functions of iPSC-derived mesenchymal stromal cells (2026) · cites this paper as Yan et al., 2021

    The section on mitochondrial transfer in the regulation of MSC functions (page unavailable) describes intercellular transfer of MSC mitochondria through nanotubes and extracellular vesicles, with effects on recipient cells. The section on mitochondrial function and energy metabolism pathways links metabolism to MSC function. Our copy does not establish the claimed link between mitochondrial metabolism and secretion of trophic factors. (LLM, conf=0.84)

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Sorted by citations

Authors
Yan, W., Diao, S., & Fan, Z.
Affiliations
Capital Medical University (CN)
Corresponding author
Fan, Zhipeng
ORCID
Venue
Stem Cell Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2021-02-17
Volume
12
Issue
1
Pages
140-140
ISSN
1757-6512 (ISSN-L)
DOI
10.1186/s13287-021-02194-z
PMC
PMC7890860
OpenAlex
W3129300023
Cited by
167
References
14
Citations by year
2026: 34 · 2025: 44 · 2024: 34 · 2023: 35 · 2022: 15 · 2021: 5
FWCI
3.17
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cell Research & Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Sciences Foundation of China (81625005, 81800923)
  • CAMS Innovation Fund for Medical Sciences (2019-I2M-5-031)
  • Program from Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction (KFKT2019012)
Topics
  • Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
mesenchymal stem cells, mitochondria, mitochondrial bioenergetics, mitochondrial dynamics, mitochondrial morphology, mitochondrial transfer, stem cell differentiation, stem cell aging, apoptosis, cell therapy
MeSH terms
Cell Differentiation, Energy Metabolism, Mitochondria, Mesenchymal Stem Cell Transplantation, Mesenchymal Stem Cells, Cell- and Tissue-Based Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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