Mitochondrial fusion and fission in cell life and death

Mitochondria, Oxidants, and Aging

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Regulation mechanisms and signaling pathways of autophagy

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

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PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin

Narendra, D. P., Jin, S. M., Tanaka, A., Suen, D.-F., Gautier, C. A., Shen, J., Cookson, M. R., & Youle, R. J. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000298 · Cited by 2,944 · see citing works

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

de Brito, O. M., & Scorrano, L. (2008) · Nature · doi:10.1038/nature07534 · Cited by 2,442 · see citing works

PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

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The Role of Dynamin-Related Protein 1, a Mediator of Mitochondrial Fission, in Apoptosis

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Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

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The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498 · see citing works

Translocation of Proteins into Mitochondria

Neupert, W., & Herrmann, J. M. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.052705.163409 · Cited by 1,486 · see citing works

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

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Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

Hailey, D. W., Rambold, A. S., Satpute‐Krishnan, P., Mitra, K., Sougrat, R., Kim, P. K., & Lippincott‐Schwartz, J. (2010) · Cell · doi:10.1016/j.cell.2010.04.009 · Cited by 1,419 · see citing works

The dynamin superfamily: universal membrane tubulation and fission molecules?

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Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction

Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376 · cited 1× · see citing works

Functions and dysfunctions of mitochondrial dynamics

Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369 · see citing works

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

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OPA1 requires mitofusin 1 to promote mitochondrial fusion

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Mitochondrial dynamics and apoptosis

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Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.

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Mitochondrial fusion is required for mtDNA stability in skeletal muscle and tolerance of mtDNA mutations

Chen, H., Vermulst, M., Wang, Y. E., Chomyn, A., Prolla, T. A., McCaffery, J. M., & Chan, D. C. (2010) · Cell · doi:10.1016/j.cell.2010.02.026 · Cited by 1,211 · see citing works

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

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Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria

Cereghetti, G. M., Stangherlin, A., de Brito, O. M., Chang, C. R., Blackstone, C., Bernardi, P., & Scorrano, L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808249105 · Cited by 1,129 · see citing works

Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice

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Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis

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Reversible phosphorylation of Drp1 by cyclic AMP‐dependent protein kinase and calcineurin regulates mitochondrial fission and cell death

Cribbs, J. T., & Strack, S. (2007) · EMBO Reports · doi:10.1038/sj.embor.7401062 · Cited by 1,024 · see citing works

Control of mitochondrial morphology by a human mitofusin

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Mitochondrial fragmentation in neurodegeneration.

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Mitochondrial fusion protects against neurodegeneration in the cerebellum

Chen, H., McCaffery, J. M., & Chan, D. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.026 · Cited by 924 · see citing works

Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

Koshiba, T., Detmer, S. A., Kaiser, J. T., Chen, H., McCaffery, J. M., & Chan, D. C. (2004) · Science · doi:10.1126/science.1099793 · Cited by 910 · see citing works

Regulation of mitochondrial morphology through proteolytic cleavage of OPA1

Ishihara, N., Fujita, Y., Oka, T., & Mihara, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601184 · Cited by 899 · see citing works

Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis

Karbowski, M., Lee, Y.-J., Gaume, B., Jeong, S.-Y., Frank, S., Nechushtan, A., Santel, A., Fuller, M., Smith, C. L., & Youle, R. J. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200209124 · Cited by 846 · see citing works

The Mitochondrial Protein hFis1 Regulates Mitochondrial Fission in Mammalian Cells through an Interaction with the Dynamin-Like Protein DLP1

Yoon, Y., Krueger, E. W., Oswald, B. J., & McNiven, M. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5409-5420.2003 · Cited by 820 · see citing works

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

Song, Z., Chen, H., Fiket, M., Alexander, C., & Chan, D. C. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704110 · Cited by 818 · see citing works

The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast

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The Machines that Divide and Fuse Mitochondria

Hoppins, S., Lackner, L., & Nunnari, J. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.071905.090048 · Cited by 790 · see citing works

Mitochondrial fission in apoptosis

Youle, R. J., & Karbowski, M. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1697 · Cited by 773 · see citing works

The Novel Tail-anchored Membrane Protein Mff Controls Mitochondrial and Peroxisomal Fission in Mammalian Cells

Gandre-Babbe, S., & van der Bliek, A. M. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-12-1287 · Cited by 769 · see citing works

SLP‐2 is required for stress‐induced mitochondrial hyperfusion

Tondera, D., Grandemange, S., Jourdain, A. A., Karbowski, M., Mattenberger, Y., Herzig, S., Cruz, S. D., Clerc, P., Lauria, I., Merkwirth, C., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.89 · Cited by 767 · see citing works

A Lethal Defect of Mitochondrial and Peroxisomal Fission

Waterham, H. R., Koster, J., van Roermund, C. W. T., Mooyer, P. A. W., Wanders, R. J. A., & Leonard, J. V. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa064436 · Cited by 749 · see citing works

Mitochondrial Morphology and Dynamics in Yeast and Multicellular Eukaryotes

Okamoto, K., & Shaw, J. M. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.093019 · Cited by 737 · see citing works

Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

Cipolat, S., Rudka, T., Hartmann, D., Costa, V., Serneels, L., Craessaerts, K., Metzger, K., Frezza, C., Annaert, W. G., D'adamio, L., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.021 · Cited by 735 · see citing works

<i>Drosophila</i> Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin

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A Human Dynamin-related Protein Controls the Distribution of Mitochondria

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Dnm1p Gtpase-Mediated Mitochondrial Fission Is a Multi-Step Process Requiring the Novel Integral Membrane Component Fis1p

Mozdy, A. D., McCaffery, J. M., & Shaw, J. M. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.367 · Cited by 725 · see citing works

Mechanisms of membrane fusion: disparate players and common principles

Martens, S., & McMahon, H. (2008) · Nature reviews. Molecular cell biology · doi:10.1038/nrm2417 · Cited by 715 · see citing works

AN ELECTRON MICROSCOPE STUDY OF THE MITOCHONDRIAL STRUCTURE

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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

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C. elegans Dynamin-Related Protein DRP-1 Controls Severing of the Mitochondrial Outer Membrane

Labrousse, A. M., Zappaterra, M. D., Rube, D. A., & van der Bliek, A. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80391-3 · Cited by 670 · see citing works

The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice

Wakabayashi, J., Zhang, Z., Wakabayashi, N., Tamura, Y., Fukaya, M., Kensler, T. W., Iijima, M., & Sesaki, H. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903065 · Cited by 667 · see citing works

hFis1, a Novel Component of the Mammalian Mitochondrial Fission Machinery

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Role of Bax and Bak in mitochondrial morphogenesis

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A hyperfused mitochondrial state achieved at G 1 –S regulates cyclin E buildup and entry into S phase

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Dnm1 forms spirals that are structurally tailored to fit mitochondria

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Developmentally Regulated Mitochondrial Fusion Mediated by a Conserved, Novel, Predicted GTPase

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Cargo-Selected Transport from the Mitochondria to Peroxisomes Is Mediated by Vesicular Carriers

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Mitochondria are morphologically and functionally heterogeneous within cells

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Mitochondrial Fusion in Yeast Requires the Transmembrane GTPase Fzo1p

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Regulation of OPA1 processing and mitochondrial fusion by m -AAA protease isoenzymes and OMA1

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Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo

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Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery

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Division versus Fusion: Dnm1p and Fzo1p Antagonistically Regulate Mitochondrial Shape

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GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission

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Versatility of the mitochondrial protein import machinery

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Bax/Bak promote sumoylation of DRP1 and its stable association with mitochondria during apoptotic cell death

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Inducible proteolytic inactivation of OPA1 mediated by the OMA1 protease in mammalian cells

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Mitochondrial filaments and clusters as intracellular power-transmitting cables

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The organization and inheritance of the mitochondrial genome

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The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division

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Mitochondrial Inner-Membrane Fusion and Crista Maintenance Requires the Dynamin-Related GTPase Mgm1

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Regulation of the mitochondrial dynamin-like protein Opa1 by proteolytic cleavage

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Mitochondrial Fusion Intermediates Revealed in Vitro

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Genetic Basis of Mitochondrial Function and Morphology in Saccharomyces cerevisiae

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Inter-mitochondrial complementation: Mitochondria-specific system preventing mice from expression of disease phenotypes by mutant mtDNA

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The Dynamin-related GTPase, Dnm1p, Controls Mitochondrial Morphology in Yeast

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CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology

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Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation*

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Human cells are protected from mitochondrial dysfunction by complementation of DNA products in fused mitochondria

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MARCH‐V is a novel mitofusin 2‐ and Drp1‐binding protein able to change mitochondrial morphology

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Mitochondrial membrane remodelling regulated by a conserved rhomboid protease

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Processing of Mgm1 by the Rhomboid-type Protease Pcp1 Is Required for Maintenance of Mitochondrial Morphology and of Mitochondrial DNA

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A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics

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Mdv1p Is a Wd Repeat Protein That Interacts with the Dynamin-Related Gtpase, Dnm1p, to Trigger Mitochondrial Division

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Dynamin-like protein 1 is involved in peroxisomal fission

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Fzo1p Is a Mitochondrial Outer Membrane Protein Essential for the Biogenesis of Functional Mitochondria in Saccharomyces cerevisiae

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The Dynamin-Related Gtpase, Mgm1p, Is an Intermembrane Space Protein Required for Maintenance of Fusion Competent Mitochondria

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Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins

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MAPL is a new mitochondrial SUMO E3 ligase that regulates mitochondrial fission

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Behavior of Mitochondria in the Living Cell

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DRP-1-mediated mitochondrial fragmentation during EGL-1-induced cell death in C. elegans

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Frequent fusion and fission of plant mitochondria with unequal nucleoid distribution

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