Cited by 236Tissue Engineering and Regenerative Medicine3D Printing in Biomedical ResearchLiver physiology and pathology

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Assessing Porcine Liver-Derived Biomatrix for Hepatic Tissue Engineering

Lin, Paul, Chan, Warren C.W., Badylak, Stephen F., Bhatia, Sangeeta N.·2004·Tissue Engineering

DOI 10.1089/ten.2004.10.1046

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Abstract

Acellular, biologically derived matrices such as small intestinal submucosa have been extensively utilized to induce tissue regeneration and remodeling of connective tissue, vascular grafts, and urinary bladder; however, decellularized scaffolds have not been explored for their potential utility in hepatic tissue engineering. In the case of both extracorporeal hepatocyte-based devices and implantable hepatocyte-scaffold tissue-engineered constructs, maintenance of hepatocellular function is of prime importance. In this study, we specifically explored decellularized, porcine, liver-derived biomatrix (LBM) as a bioresorbable scaffold for primary hepatocytes. Primary rat hepatocytes were cultured on LBM and compared with well-characterized hepatocyte culture models--double-gel cultures that promote maintenance of liver-specific functions for many weeks, and adsorbed collagen monolayers that lead to the rapid decline of hepatocellular function and viability. Hepatocytes were maintained for up to 45 days on LBM and liver-specific functions such as albumin synthesis, urea production, and P-450 IA1 activity were found to be significantly improved over adsorbed collagen cultures. Our data indicate that LBM may be a favorable alternative to existing scaffolds for tissue engineering in that it is bioresorbable, can be easily manipulated, and supports long-term hepatocellular functions in vitro.

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Authors: Lin, P., Chan, W. C. W., Badylak, S. F., & Bhatia, S. N.
Affiliations: University of California San Diego (US)
University of Toronto (CA)
University of Pittsburgh (US)
ORCID: Lin, Paul
Chan, Warren C.W.
Badylak, Stephen F.
Bhatia, Sangeeta N.
Venue: Tissue Engineering
Publisher: SAGE Publications
Published: 2004-07
Volume: 10
Issue: 7-8
Pages: 1046-1053
ISSN: 1076-3279 (ISSN-L)
1557-8690
DOI: 10.1089/ten.2004.10.1046
OpenAlex: W2030077110
Cited by: 236
References: 52
Citations by year: 2026: 1 · 2025: 4 · 2024: 11 · 2023: 10 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 15 · 2018: 9 · 2017: 8 · 2016: 10 · 2015: 17 · 2014: 20 · 2013: 17 · 2012: 11
FWCI: 5.97
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Tissue Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (T32HL007089)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK056966, R01DK065152)
National Institute of Biomedical Imaging and Bioengineering (R01EB000506)
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Keywords: porcine liver, liver tissue engineering, bioresorbable scaffolds, primary hepatocytes, hepatocyte culture, albumin synthesis, urea synthesis, cytochrome P450
MeSH terms: Animals, Cell Adhesion, Cell Survival, Cells, Cultured, Extracellular Matrix, Female, Liver, Rats, Inbred Lew, Cell Culture Techniques, Liver, Artificial, Hepatocytes, Tissue Engineering, Cell Size, Rats

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Assessing Porcine Liver-Derived Biomatrix for Hepatic Tissue Engineering

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