The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation
Open accessAbstract
We report here the first attempt to produce and use whole acellular (AC) lung as a matrix to support development of engineered lung tissue from murine embryonic stem cells (mESCs). We compared the influence of AC lung, Gelfoam, Matrigel, and a collagen I hydrogel matrix on the mESC attachment, differentiation, and subsequent formation of complex tissue. We found that AC lung allowed for better retention of cells with more differentiation of mESCs into epithelial and endothelial lineages. In constructs produced on whole AC lung, we saw indications of organization of differentiating ESC into three-dimensional structures reminiscent of complex tissues. We also saw expression of thyroid transcription factor-1, an immature lung epithelial cell marker; pro-surfactant protein C, a type II pneumocyte marker; PECAM-1/CD31, an endothelial cell marker; cytokeratin 18; alpha-actin, a smooth muscle marker; CD140a or platelet-derived growth factor receptor-alpha; and Clara cell protein 10. There was also evidence of site-specific differentiation in the trachea with the formation of sheets of cytokeratin-positive cells and Clara cell protein 10-expressing Clara cells. Our findings support the utility of AC lung as a matrix for engineering lung tissue and highlight the critical role played by matrix or scaffold-associated cues in guiding ESC differentiation toward lung-specific lineages.
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1 retracted
RETRACTED: Clinical transplantation of a tissue-engineered airway
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Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart
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Reprint of: Extracellular matrix as a biological scaffold material: Structure and function
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Cited by
An overview of tissue and whole organ decellularization processes
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Regeneration and orthotopic transplantation of a bioartificial lung
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Extracellular matrix-based materials for regenerative medicine
Hussey, G. S., Dziki, J. L., & Badylak, S. F. (2018) · Nature Reviews Materials · doi:10.1038/s41578-018-0023-x · Cited by 844
Decellularization Strategies for Regenerative Medicine: From Processing Techniques to Applications
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Metadata
- Authors
- Cortiella, J., Niles, J., Cantu, A., Brettler, A., Pham, A., Vargas, G., Winston, S., Wang, J., Walls, S., & Nichols, J. E.
- Venue
- Tissue Engineering Part A
- Publisher
- SAGE Publications
- Published
- 2010-08
- Volume
- 16
- Issue
- 8
- Pages
- 2565-2580
- ISSN
- 1937-3341 (ISSN-L)
- 1937-335X
- OpenAlex
- W2041180426
- Cited by
- 381
- References
- 63
- FWCI
- 30.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Cortiella, J., Niles, J., Cantu, A., Brettler, A., Pham, A., Vargas, G., Winston, S., Wang, J., Walls, S., & Nichols, J. E. (2010). Influence of Acellular Natural Lung Matrix on Murine Embryonic Stem Cell Differentiation and Tissue Formation. Tissue Engineering Part A. https://doi.org/10.1089/ten.tea.2009.0730
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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