The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Functions of Thyroid Hormone Receptors in Mice
Abstract
Thyroid hormone receptors (TRs) play a central role in mediating the actions of thyroid hormone in development and homeostasis in vertebrate species. The TRs are nuclear receptors that act as ligand-regulated transcription factors. There are two TR genes (TRalpha and TRbeta), each capable of generating different variant products, suggesting a potentially complex array of TR pathways. Targeted mutagenesis in the mouse has indicated that there are specific individual functions for the TR genes in vivo. The deletion of combinations of TRalpha and TRbeta variants has revealed that additional functions are convergently regulated by both TR genes and indicates that control of an extended range of functions is facilitated by a network of specific and common TR pathways. The TR-deficient mouse models have allowed investigation of the TR pathways underlying many functions of thyroid hormone and provide a unique perspective on receptor-mediated mechanisms of biological control.
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Cites
The nuclear receptor superfamily: the second decade
Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schütz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90199-x · Cited by 6,964
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The Deiodinase Family of Selenoproteins
GERMAIN, D. L. S., & GALTON, V. A. (1997) · Thyroid · doi:10.1089/thy.1997.7.655 · Cited by 342
Lechan, R. M., Qi, Y., Jackson, I. M., & Mahdavi, V (1994) · Endocrinology · doi:10.1210/endo.135.1.7516871 · Cited by 113
Cited by
Nuclear Receptors and Lipid Physiology: Opening the X-Files
Chawla, A., Repa, J. J., Evans, R. M., & Mangelsdorf, D. J. (2001) · Science · doi:10.1126/science.294.5548.1866 · Cited by 2,085
Physiological and Molecular Basis of Thyroid Hormone Action
Yen, P. M. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1097 · Cited by 2,011
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
Bookout, A. L., Jeong, Y., Downes, M., Yu, R. T., Evans, R. M., & Mangelsdorf, D. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.049 · Cited by 1,015
Thyroid Hormone Action in the Heart
Kahaly, G. J., & Dillmann, W. H. (2005) · Endocrine Reviews · doi:10.1210/er.2003-0033 · Cited by 717
Thyroid hormone receptors and resistance to thyroid hormone disorders
Ortiga-Carvalho, T. M., Sidhaye, A. R., & Wondisford, F. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.143 · Cited by 383
Metadata
- Authors
- Forrest, D., & Vennström, B.
- Venue
- Thyroid
- Publisher
- SAGE Publications
- Published
- 2000-01
- Volume
- 10
- Issue
- 1
- Pages
- 41-52
- ISSN
- 1050-7256 (ISSN-L)
- 1557-9077
- OpenAlex
- W2070712357
- Cited by
- 299
- References
- 4
- FWCI
- 16.97
- Type
- journal article
- Language
- en
- Open access
- closed
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