The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Thyroid Hormone Action in the Heart
Abstract
The heart is a major target organ for thyroid hormone action, and marked changes occur in cardiac function in patients with hypo- or hyperthyroidism. T(3)-induced changes in cardiac function can result from direct or indirect T(3) effects. Direct effects result from T(3) action in the heart itself and are mediated by nuclear or extranuclear mechanisms. Extranuclear T(3) effects, which occur independent of nuclear T(3) receptor binding and increases in protein synthesis, influence primarily the transport of amino acids, sugars, and calcium across the cell membrane. Nuclear T(3) effects are mediated by the binding of T(3) to specific nuclear receptor proteins, which results in increased transcription of T(3)-responsive cardiac genes. The T(3) receptor is a member of the ligand-activated transcription factor family and is encoded by cellular erythroblastosis A (c-erb A) genes. T(3) also leads to an increase in the speed of diastolic relaxation, which is caused by the more efficient pumping of the calcium ATPase of the sarcoplasmic reticulum. This T(3) effect results from T(3)-induced increases in the level of the mRNA coding for the sarcoplasmic reticulum calcium ATPase protein, leading to an increased number of calcium ATPase pump units in the sarcoplasmic reticulum.
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Citations
Cites
Low Serum Thyrotropin Concentrations as a Risk Factor for Atrial Fibrillation in Older Persons
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“rather uncommon in the absence of additional symptoms and signs of hyperthyroidism (173).”
BackgroundParle, J. V., Maisonneuve, P., Sheppard, M. C., Boyle, P., & Franklyn, J. A. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06067-6 · Cited by 669
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“tone may contribute to the T3-induced changes in vascular resistance (122, 123).”
BackgroundL-Thyroxine Therapy in Subclinical Hypothyroidism: A Double-Blind, Placebo-Controlled Trial
COOPER, D. S., HALPERN, R., WOOD, L. C., LEVIN, A. A., & RIDGWAY, E. C. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-101-1-18 · Cited by 423
Thyroid hormone and the cardiovascular system
Klein, I. (1990) · The American Journal of Medicine · doi:10.1016/0002-9343(90)90531-h · Cited by 370
Left Ventricular Diastolic Dysfunction in Patients with Subclinical Hypothyroidism
Biondi, B., Fazio, S., Palmieri, E. A., Carella, C., Panza, N., Cittadini, A., Bonè, F., Lombardi, G., & Saccà, L. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5733 · Cited by 334
Subclinical hyperthyroidism as a risk factor for atrial fibrillation
Auer, J., Scheibner, P., Mische, T., Langsteger, W., Eber, O., & Eber, B. (2001) · American Heart Journal · doi:10.1067/mhj.2001.119370 · Cited by 314
Molecular biological and biochemical characterization of the human type 2 selenodeiodinase.
Salvatore, D., Bartha, T., Harney, J. W., & Larsen, P. R. (1996) · Endocrinology · doi:10.1210/endo.137.8.8754756 · Cited by 284
Thyroid hormone and blood pressure regulation
Danzi, S., & Klein, I. (2003) · Current Hypertension Reports · doi:10.1007/s11906-003-0060-7 · Cited by 261
Cited by
The Clinical Significance of Subclinical Thyroid Dysfunction
Biondi, B., & Cooper, D. S. (2008) · Endocrine Reviews · doi:10.1210/er.2006-0043 · Cited by 1,418
Molecular Aspects of Thyroid Hormone Actions
Cheng, S.-Y., Leonard, J. L., & Davis, P. J. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0007 · Cited by 1,384
Klein, I., & Danzi, S. (2007) · Circulation · doi:10.1161/circulationaha.106.678326 · Cited by 1,324
2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism
Kahaly, G. J., Bartalena, L., Hegedüs, L., Leenhardt, L., Poppe, K., & Pearce, S. H. (2018) · European Thyroid Journal · doi:10.1159/000490384 · Cited by 940
Self-citationMuscle as a “Mediator” of Systemic Metabolism
Baskin, K. K., Winders, B. R., & Olson, E. N. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.021 · Cited by 333
Metadata
- Authors
- Kahaly, G. J., & Dillmann, W. H.
- Venue
- Endocrine Reviews
- Publisher
- The Endocrine Society
- Published
- 2005-01-04
- Volume
- 26
- Issue
- 5
- Pages
- 704-728
- ISSN
- 0163-769X (ISSN-L)
- 1945-7189
- OpenAlex
- W1995135039
- Cited by
- 717
- References
- 20
- FWCI
- 18.24
- Type
- journal article
- Language
- en
- Open access
- closed
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