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Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells.
Open accessAbstract
Intercellular communication of epithelial cells was examined by measuring changes in intracellular calcium concentration ([Ca2+]i). Mechanical stimulation of respiratory tract ciliated cells in culture induced a wave of increasing Ca2+ that spread, cell by cell, from the stimulated cell to neighboring cells. The communication of these Ca2+ waves between cells was restricted or blocked by halothane, an anesthetic known to uncouple cells. In the absence of extracellular Ca2+, the mechanically stimulated cell showed no change or a decrease in [Ca2+]i, whereas [Ca2+]i increased in neighboring cells. Iontophoretic injection of inositol 1,4,5-trisphosphate (IP3) evoked a communicated Ca2+ response that was similar to that produced by mechanical stimulation. These results support the hypothesis that IP3 acts as a cellular messenger that mediates communication through gap junctions between ciliated epithelial cells.
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Cites
Glutamate Induces Calcium Waves in Cultured Astrocytes: Long-Range Glial Signaling
Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., & Smith, S. J. (1990) · Science · doi:10.1126/science.1967852 · Cited by 1,846
Cited by
A single-pool model for intracellular calcium oscillations and waves in the Xenopus laevis oocyte
Atri, A., Amundson, J., Clapham, D., & Sneyd, J. (1993) · Biophysical Journal · doi:10.1016/s0006-3495(93)81191-3 · Cited by 344
Intercellular Ca2+Waves: Mechanisms and Function
Leybaert, L., & Sanderson, M. J. (2012) · Physiological Reviews · doi:10.1152/physrev.00029.2011 · Cited by 331
Self-citationMechanisms and function of intercellular calcium signaling
Sanderson, M. J., Charles, A. C., Boitano, S., & Dirksen, E. R. (1994) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(94)90136-8 · Cited by 305
Self-citationConnexins: Key Mediators of Endocrine Function
Bosco, D., Haefliger, J.-A., & Meda, P. (2011) · Physiological Reviews · doi:10.1152/physrev.00027.2010 · Cited by 169
A mechanism for sensing noise damage in the inner ear
Gale, J. E., Piazza, V., Ciubotaru, C. D., & Mammano, F. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.002 · Cited by 149
Metadata
- Authors
- Sanderson, M. J., Charles, A. C., & Dirksen, E. R.
- Venue
- Cell Regulation
- Published
- 1990-07
- Volume
- 1
- Issue
- 8
- Pages
- 585-596
- ISSN
- 1044-2030 (ISSN-L)
- OpenAlex
- W2100132948
- Cited by
- 366
- References
- 1
- FWCI
- 5.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Sanderson, M. J., Charles, A. C., & Dirksen, E. R. (1990). Mechanical stimulation and intercellular communication increases intracellular Ca2+ in epithelial cells. Cell Regulation. https://doi.org/10.1091/mbc.1.8.585
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
