The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
α5β1 Integrin Controls Cyclin D1 Expression by Sustaining Mitogen-activated Protein Kinase Activity in Growth Factor-treated Cells
Open accessAbstract
Cyclin D1 expression is jointly regulated by growth factors and cell adhesion to the extracellular matrix in many cell types. Growth factors are thought to regulate cyclin D1 expression because they stimulate sustained extracellular signal-regulated kinase (ERK) activity. However, we show here that growth factors induce transient ERK activity when added to suspended fibroblasts and sustained ERK activity only when added to adherent fibroblasts. Cell attachment to fibronectin or anti-α5β1 integrin is sufficient to sustain the ERK signal and to induce cyclin D1 in growth factor-treated cells. Moreover, when we force the sustained activation of ERK, by conditional expression of a constitutively active MAP kinase/ERK kinase, we overcome the adhesion requirement for expression of cyclin D1. Thus, at least in part, fibroblasts are mitogen and anchorage dependent, because integrin action allows for a sustained ERK signal and the expression of cyclin D1 in growth factor-treated cells.
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Citations
Cites
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862
Cited by
Meloche, S., & Pouysségur, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210414 · Cited by 1,091
Genetic and cell biological analysis of integrin outside-in signaling
Legate, K. R., Wickström, S. A., & Fässler, R. (2009) · Genes & Development · doi:10.1101/gad.1758709 · Cited by 802
The Extracellular Matrix Modulates the Metastatic Journey
Kai, F., Drain, A. P., & Weaver, V. M. (2019) · Developmental Cell · doi:10.1016/j.devcel.2019.03.026 · Cited by 537
Integrins and cell proliferation
Schwartz, M. A., & Assoian, R. K. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.14.2553 · Cited by 518
Self-citationIntegrating the MAP kinase signal into the G1 phase cell cycle machinery
Roovers, K., & Assoian, R. K. (2000) · BioEssays · doi:10.1002/1521-1878(200009)22:9<818::aid-bies7>3.0.co;2-6 · Cited by 458
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Metadata
- Authors
- Roovers, K., Davey, G., Zhu, X., Bottazzi, M. E., & Assoian, R. K.
- Venue
- Molecular Biology of the Cell
- Published
- 1999-10
- Volume
- 10
- Issue
- 10
- Pages
- 3197-3204
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2164767056
- Cited by
- 212
- References
- 1
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Roovers, K., Davey, G., Zhu, X., Bottazzi, M. E., & Assoian, R. K. (1999). α5β1 Integrin Controls Cyclin D1 Expression by Sustaining Mitogen-activated Protein Kinase Activity in Growth Factor-treated Cells. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.10.10.3197
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
