The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
The Extracellular Matrix Modulates the Metastatic Journey
Open accessAbstract
The extracellular matrix is perturbed in tumors. The tumor matrix promotes the growth, survival and invasion of the cancer and modifies fibroblast and immune cell behavior to drive metastasis and impair treatment. Here, we discuss how the tumor matrix regulates metastasis by fostering tumor cell invasion into the stroma and migration towards the vasculature. We describe the role of the tumor matrix on cancer cell intravasation and vascular dissemination. We examine the impact of the matrix on disseminated tumor cell extravasation and on tumor dormancy and metastatic outgrowth. Finally, we discuss the clinical outcome of therapeutics that normalize tumor-matrix interactions.
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Citations
Cites
2 retracted
Procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis
Gilkes, D. M., Bajpai, S., Wong, C. C., Chaturvedi, P., Hubbi, M. E., Wirtz, D., & Semenza, G. L. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-12-0629 · Cited by 252
RetractedDiscoidin Domain Receptors: Potential Actors and Targets in Cancer
Rammal, H., Saby, C., Magnien, K., Gulick, L. V., Garnotel, R., Buache, É., Btaouri, H. E., Jeannesson, P., & Morjani, H. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00055 · Cited by 133
RetractedMolecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
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Self-citationTensional homeostasis and the malignant phenotype
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Self-citationThe Extracellular Matrix: Not Just Pretty Fibrils
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VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
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Cited by
The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth
de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059
Concepts of extracellular matrix remodelling in tumour progression and metastasis
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Monteran, L., & Erez, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01835 · Cited by 675
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Keller, L., & Pantel, K. (2019) · Nature Reviews Cancer · doi:10.1038/s41568-019-0180-2 · Cited by 544
Fibroblasts in cancer: Unity in heterogeneity
Chhabra, Y., & Weeraratna, A. T. (2023) · Cell · doi:10.1016/j.cell.2023.03.016 · Cited by 474
Metadata
- Authors
- Kai, F., Drain, A. P., & Weaver, V. M.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 49
- Issue
- 3
- Pages
- 332-346
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2943229766
- Cited by
- 537
- References
- 125
- FWCI
- 22.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
