The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Mechanisms of G2 Arrest in Response to Overexpression of p53
Open accessAbstract
Overexpression of p53 causes G2 arrest, attributable in part to the loss of CDC2 activity. Transcription of cdc2 andcyclin B1, determined using reporter constructs driven by the two promoters, was suppressed in response to the induction of p53. Suppression requires the regions −287 to −123 of thecyclin B1 promoter and −104 to −74 of thecdc2 promoter. p53 did not affect the inhibitory phosphorylations of CDC2 at threonine 14 or tyrosine 15 or the activity of the cyclin-dependent kinase that activates CDC2 by phosphorylating it at threonine 161. Overexpression of p53 may also interfere with the accumulation of CDC2/cyclin B1 in the nucleus, required for cells to enter mitosis. Constitutive expression of cyclin B1, alone or in combination with the constitutively active CDC2 protein T14A Y15F, did not reverse p53-dependent G2 arrest. However, targeting cyclin B1 to the nucleus in cells also expressing CDC2 T14A Y15F did overcome this arrest. It is likely that several distinct pathways contribute to p53-dependent G2 arrest.
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Cites
p53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803
Sanchez, Y., Wong, C., Thoma, R. S., Richman, R., Wu, Z., Piwnica-Worms, H., & Elledge, S. J. (1997) · Science · doi:10.1126/science.277.5331.1497 · Cited by 1,320
Agarwal, M. L., Agarwal, A., Taylor, W. R., & Stark, G. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8493 · Cited by 858
Self-citation
Cited by
Cell death by mitotic catastrophe: a molecular definition
Castedo, M., Perfettini, J.-L., Roumier, T., Andreau, K., Medema, R., & Kroemer, G. (2004) · Oncogene · doi:10.1038/sj.onc.1207528 · Cited by 1,269
Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM
Engeland, K. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.172 · Cited by 656
Cell cycle checkpoint signaling:
Pietenpol, J. A., & Stewart, Z. A. (2002) · Toxicology · doi:10.1016/s0300-483x(02)00460-2 · Cited by 473
Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe
Castedo, M., Perfettini, J.-L., Roumier, T., & Kroemer, G. (2002) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4401130 · Cited by 345
Control of the G2/M Transition
Stark, G. R., & Taylor, W. R. (2006) · Molecular Biotechnology · doi:10.1385/mb:32:3:227 · Cited by 279
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Metadata
- Authors
- Taylor, W. R., DePrimo, S. E., Agarwal, A., Agarwal, M. L., Schönthal, A. H., Katula, K. S., & Stark, G. R.
- Venue
- Molecular Biology of the Cell
- Published
- 1999-11
- Volume
- 10
- Issue
- 11
- Pages
- 3607-3622
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2113993278
- Cited by
- 195
- References
- 4
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Taylor, W. R., DePrimo, S. E., Agarwal, A., Agarwal, M. L., Schönthal, A. H., Katula, K. S., & Stark, G. R. (1999). Mechanisms of G2 Arrest in Response to Overexpression of p53. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.10.11.3607
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