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Ca2+Entry through Store-operated Channels in Mouse Sperm Is Initiated by Egg ZP3 and Drives the Acrosome Reaction
Open accessAbstract
Fertilization occurs after the completion of the sperm acrosome reaction, a secretory event that is triggered during gamete adhesion. ZP3, an egg zona pellucida glycoprotein, produces a sustained increase of the internal Ca 2+concentration in mouse sperm, leading to acrosome reactions. Here we show that the sustained Ca 2+concentration increase is due to the persistent activation of a Ca 2+influx mechanism during the late stages of ZP3 signal transduction. These cells also possess a Ca 2+store depletion–activated Ca 2+entry pathway that is open after treatment with thapsigargin. Thapsigargin and ZP3 activate the same Ca 2+permeation mechanism, as demonstrated by fluorescence quenching experiments and by channel antagonists. These studies show that ZP3 generates a sustained Ca 2+influx through a store depletion–operated pathway and that this drives the exocytotic acrosome reaction.
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Citations
Cites
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Li, H.-S., Xu, X.-Z. S., & Montell, C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80838-7 · Cited by 345
Cited by
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
The TRP Superfamily of Cation Channels
Montell, C. (2005) · Science's STKE · doi:10.1126/stke.2722005re3 · Cited by 989
A sperm ion channel required for sperm motility and male fertility
Ren, D., Navarro, B., Perez, G., Jackson, A. C., Hsu, S., Shi, Q., Tilly, J. L., & Clapham, D. E. (2001) · Nature · doi:10.1038/35098027 · Cited by 957
Control of hyperactivation in sperm
Suarez, S. S. (2008) · Human Reproduction Update · doi:10.1093/humupd/dmn029 · Cited by 584
A profile of fertilization in mammals
Wassarman, P. M., Jovine, L., & Litscher, E. S. (2001) · Nature Cell Biology · doi:10.1038/35055178 · Cited by 393
Metadata
- Authors
- O'Toole, C. M. B., Arnoult, C., Darszon, A., Steinhardt, R. A., & Florman, H. M.
- Venue
- Molecular Biology of the Cell
- Published
- 2000-05
- Volume
- 11
- Issue
- 5
- Pages
- 1571-1584
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2014999503
- Cited by
- 228
- References
- 1
- FWCI
- 8.78
- Type
- journal article
- Language
- en
- Open access
- green
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- O'Toole, C. M. B., Arnoult, C., Darszon, A., Steinhardt, R. A., & Florman, H. M. (2000). Ca2+Entry through Store-operated Channels in Mouse Sperm Is Initiated by Egg ZP3 and Drives the Acrosome Reaction. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.11.5.1571
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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