The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.
Open accessAbstract
Connective tissue growth factor (CTGF) is a cysteine-rich peptide that exhibits platelet-derived growth factor (PDGF)-like biological and immunological activities. CTGF is a member of a family of peptides that include serum-induced immediate early gene products, a v-src-induced peptide, and a putative avian transforming gene, nov. In the present study, we demonstrate that human foreskin fibroblasts produce high levels of CTGF mRNA and protein after activation with transforming growth factor beta (TGF-beta) but not other growth factors including PDGF, epidermal growth factor, and basic fibroblast growth factor. Because of the high level selective induction of CTGF by TGF-beta, it appears that CTGF is a major autocrine growth factor produced by TGF-beta-treated human skin fibroblasts. Cycloheximide did not block the large TGF-beta stimulation of CTGF gene expression, indicating that it is directly regulated by TGF-beta. Similar regulatory mechanisms appear to function in vivo during wound repair where there is a coordinate expression of TGF-beta 1 before CTGF in regenerating tissue, suggesting a cascade process for control of tissue regeneration and repair.
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Ignotz, R. A., & Massagué, J. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)35666-1 · Cited by 2,492
Expression of cyr61, a growth factor-inducible immediate-early gene.
O'Brien, T. P., Yang, G. P., Sanders, L., & Lau, L. F. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.7.3569 · Cited by 310
Grotendorst, G. R., Martin, G. R., Pencev, D., Sodek, J., & Harvey, A. K. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112243 · Cited by 275
Self-citationProduction of transforming growth factor beta by human peripheral blood monocytes and neutrophils
Grotendorst, G. R., Smale, G., & Pencev, D. (1989) · Journal of Cellular Physiology · doi:10.1002/jcp.1041400226 · Cited by 262
Self-citationIdentification of a Gene Family Regulated by Transforming Growth Factor-β
Brunner, A., Chinn, J., Neubauer, M., & Purchio, A. F. (1991) · DNA and Cell Biology · doi:10.1089/dna.1991.10.293 · Cited by 124
Cited by
Regulation of Wound Healing by Growth Factors and Cytokines
WERNER, S., & GROSE, R. (2003) · Physiological Reviews · doi:10.1152/physrev.2003.83.3.835 · Cited by 3,629
PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing
Barrientos, S., Stojadinovic, O., Golinko, M. S., Brem, H., & Tomic‐Canic, M. (2008) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2008.00410.x · Cited by 3,583
Fibroblasts in fibrosis: novel roles and mediators
Kendall, R. T., & Feghali-Bostwick, C. A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00123 · Cited by 1,082
Hoek, K. S., Schlegel, N. C., Brafford, P., Sucker, A., Ugurel, S., Kumar, R., Weber, B. L., Nathanson, K. L., Phillips, D. J., Herlyn, M., et al. (2006) · Pigment Cell Research · doi:10.1111/j.1600-0749.2006.00322.x · Cited by 555
Functions and mechanisms of action of CCN matricellular proteins
Chen, C.-C., & Lau, L. F. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.07.025 · Cited by 549
Metadata
- Authors
- Igarashi, A., Okochi, H., Bradham, D. M., & Grotendorst, G. R.
- Venue
- Molecular Biology of the Cell
- Published
- 1993-06
- Volume
- 4
- Issue
- 6
- Pages
- 637-645
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2009407308
- Cited by
- 706
- References
- 5
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- green
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- Igarashi, A., Okochi, H., Bradham, D. M., & Grotendorst, G. R. (1993). Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.4.6.637
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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