Human PIG-U and Yeast Cdc91p Are the Fifth Subunit of GPI Transamidase That Attaches GPI-Anchors to Proteins

A simple method for displaying the hydropathic character of a protein

Kyte, J., & Doolittle, R. F. (1982) · Journal of Molecular Biology · doi:10.1016/0022-2836(82)90515-0 · Cited by 22,694 · see citing works

Saccharomyces genome database

Issel‐Tarver, L., Christie, K., Dolinski, K. J., Andrada, R., Balakrishnan, R., Ball, C. A., Binkley, G., Dong, S., Dwight, S. S., Fisk, D. G., et al. (2002) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(02)50972-1 · Cited by 672 · see citing works

ELO2 and ELO3, Homologues of theSaccharomyces cerevisiae ELO1 Gene, Function in Fatty Acid Elongation and Are Required for Sphingolipid Formation

Oh, C.-S., Toke, D. A., MANDALA, S. M., & Martin, C. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17376 · Cited by 487 · see citing works

Prediction of Transmembrane Segments in Proteins Utilising Multiple Sequence Alignments

Persson, B. L., & Argos, P. (1994) · Journal of Molecular Biology · doi:10.1006/jmbi.1994.1220 · Cited by 460 · see citing works

Identification of a Mammalian Long Chain Fatty Acyl Elongase Regulated by Sterol Regulatory Element-binding Proteins

Moon, Y.-A., Shah, N. A., Mohapatra, S., Warrington, J. A., & Horton, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m108413200 · Cited by 353 · see citing works

Role of a New Mammalian Gene Family in the Biosynthesis of Very Long Chain Fatty Acids and Sphingolipids

Tvrdík, P., Westerberg, R., Silve, S., Asadi, A., Jakobsson, A., Cannon, B., Loison, G., & Jacobsson, A. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.149.3.707 · Cited by 218 · see citing works

PIG‐S and PIG‐T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8

Ohishi, K., Inoue, N., & Kinoshita, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.4088 · Cited by 177 · see citing works

Yeast Gpi8p is essential for GPI anchor attachment onto proteins.

Benghezal, M., Benachour, A., Rusconi, S., Aebi, M., & Conzelmann, A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01048.x · Cited by 176 · see citing works

Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.

Hamburger, D., Egerton, M., & Riezman, H. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.3.629 · Cited by 172 · see citing works

Human dolichol‐phosphate‐mannose synthase consists of three subunits, DPM1, DPM2 and DPM3

Maeda, Y., Tanaka, S., Hino, J., Kangawa, K., & Kinoshita, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.11.2475 · Cited by 151 · see citing works

Expression Cloning of PIG-L, a CandidateN-Acetylglucosaminyl-phosphatidylinositol Deacetylase

NAKAMURA, N., Inoue, N., Watanabe, R., Takahashi, M., Takeda, J., Stevens, V. L., & Kinoshita, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.25.15834 · Cited by 143 · see citing works

Adventures of a pore-forming toxin at the target cell surface

Abrami, L., Fivaz, M. L., & BRINK, G. R. V. D. (2000) · Trends in Microbiology · doi:10.1016/s0966-842x(00)01722-4 · Cited by 136 · see citing works

Characterization of putative glycoinositol phospholipid anchor precursors in mammalian cells. Localization of phosphoethanolamine.

Hirose, S., Prince, G. M. S. H., Sevlever, D., Ravi, L., Rosenberry, T. L., Ueda, E., & Medof, M. E. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41879-0 · Cited by 132 · see citing works

Gaa1p and Gpi8p Are Components of a Glycosylphosphatidylinositol (GPI) Transamidase That Mediates Attachment of GPI to Proteins

Ohishi, K., Inoue, N., Maeda, Y., Takeda, J., Riezman, H., & Kinoshita, T. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1523 · Cited by 126 · see citing works

Requirement of N‐glycan on GPI‐anchored proteins for efficient binding of aerolysin but not Clostridium septicum α‐toxin

Hong, Y., Ohishi, K., Inoue, N., Kang, J. Y., Shime, H., Horiguchi, Y., van der Goot, F. G., Sugimoto, N., & Kinoshita, T. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf508 · Cited by 114 · see citing works

The GPI Transamidase Complex of<i>Saccharomyces cerevisiae</i>Contains Gaa1p, Gpi8p, and Gpi16p

Fraering, P., Imhof, I., Meyer, U., Strub, J.-M., van Dorsselaer, A., Vionnet, C., & Conzelmann, A. (2001) · Molecular Biology of the Cell · doi:10.1091/mbc.12.10.3295 · Cited by 111 · see citing works

Active Site Determination of Gpi8p, a Caspase-Related Enzyme Required for Glycosylphosphatidylinositol Anchor Addition to Proteins

Meyer, U., Benghezal, M., Imhof, I., & Conzelmann, A. (2000) · Biochemistry · doi:10.1021/bi992186o · Cited by 87 · see citing works

Cross-talk between Caveolae and Glycosylphosphatidylinositol-rich Domains

Abrami, L., Fivaz, M. L., Kobayashi, T., Kinoshita, T., Parton, R. G., & van der Goot, F. G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102039200 · Cited by 87 · see citing works

Requirement of PIG-F and PIG-O for Transferring Phosphoethanolamine to the Third Mannose in Glycosylphosphatidylinositol

Hong, Y., Maeda, Y., Watanabe, R., Inoue, N., Ohishi, K., & Kinoshita, T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001913200 · Cited by 84 · see citing works

An Active Carbonyl Formed during Glycosylphosphatidylinositol Addition to a Protein Is Evidence of Catalysis by a Transamidase

Maxwell, S. E., Ramalingam, S., Gerber, L., Brink, L., & Udenfriend, S. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.33.19576 · Cited by 79 · see citing works

The affected gene underlying the class K glycosylphosphatidylinositol (GPI) surface protein defect codes for the GPI transamidase

Yu, J., Nagarajan, S., Knez, J. J., Udenfriend, S., Chen, R., & Medof, M. E. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.23.12580 · Cited by 77 · see citing works

Biosynthesis of phosphatidylinositol glycan-anchored membrane proteins.

Kodukula, K., Micanovic, R., Gerber, L., Tamburrini, M., Brink, L., & Udenfriend, S. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64345-9 · Cited by 59 · see citing works

Molecular cloning of human homolog of yeast GAA1 which is required for attachment of glycosylphosphatidylinositols to proteins1

Hiroi, Y., Komuro, I., Chen, R., Hosoda, T., Mizuno, T., Kudoh, S., Georgescu, S. P., Medof, M. E., & Yazaki, Y. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01576-7 · Cited by 52 · see citing works

Structural Requirements for the Recruitment of Gaa1 into a Functional Glycosylphosphatidylinositol Transamidase Complex

Vainauskas, S., Maeda, Y., Kurniawan, H., Kinoshita, T., & Menon, A. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m205402200 · Cited by 47 · see citing works

GPI anchor transamidase ofTrypanosoma brucei: in vitro assay of the recombinant protein and VSG anchor exchange

Kang, X., Szallies, A., Rawer, M., Echner, H., & Duszenko, M. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.12.2529 · Cited by 41 · see citing works

Endoplasmic reticulum proteins involved in glycosylphosphatidylinositol‐anchor attachment

Vidugirienė, J., Vainauskas, S., Johnson, A. E., & Menon, A. K. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02106.x · Cited by 39 · see citing works

Early Events in Glycosylphosphatidylinositol Anchor Addition

Spurway, T. D., Dalley, J. A., High, S., & Bulleid, N. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m010128200 · Cited by 37 · see citing works

Enhancement of Transport-dependent Decarboxylation of Phosphatidylserine by S100B Protein in Permeabilized Chinese Hamster Ovary Cells

Kuge, O., Yamakawa, Y., & Nishijima, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101911200 · Cited by 35 · see citing works

The channel-forming toxin aerolysin

Buckley, J. T. (1992) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1992.tb05881.x · Cited by 24 · see citing works

Computed structures of core eukaryotic protein complexes

Humphreys, I. R., Pei, J., Baek, M., Krishnakumar, A., Anishchenko, I., Ovchinnikov, S., Zhang, J., Ness, T. J., Banjade, S., Bagde, S. R., et al. (2021) · Science · doi:10.1126/science.abm4805 · Cited by 542 · see citing works

Architecture and Biosynthesis of the Saccharomyces cerevisiae Cell Wall

Orlean, P. (2012) · Genetics · doi:10.1534/genetics.112.144485 · Cited by 479 · see citing works

Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids

Orlean, P., & Menon, A. K. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700002-jlr200 · Cited by 403 · see citing works

Biosynthesis and biology of mammalian GPI-anchored proteins

Kinoshita, T. (2020) · Open Biology · doi:10.1098/rsob.190290 · Cited by 344 · see citing works

A Sensitive Predictor for Potential GPI Lipid Modification Sites in Fungal Protein Sequences and its Application to Genome-wide Studies for Aspergillus nidulans, Candida albicans Neurospora crassa, Saccharomyces cerevisiae and Schizosaccharomyces pombe

Eisenhaber, B., Schneider, G., Wildpaner, M., & Eisenhaber, F. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.01.025 · Cited by 287 · see citing works

Thematic Review Series: Glycosylphosphatidylinositol (GPI) Anchors: Biochemistry and Cell Biology Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling

Kinoshita, T., & Fujita, M. (2015) · Journal of Lipid Research · doi:10.1194/jlr.r063313 · Cited by 275 · see citing works

Biosynthesis and function of GPI proteins in the yeast Saccharomyces cerevisiae

Pittet, M., & Conzelmann, A. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.05.015 · Cited by 246 · see citing works

Protein translocation across the ER membrane

Zimmermann, R., Eyrisch, S., Ahmad, M., & Helms, V. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.06.015 · Cited by 232 · see citing works

Biosynthesis and deficiencies of glycosylphosphatidylinositol

Kinoshita, T. (2014) · Proceedings of the Japan Academy Series B · doi:10.2183/pjab.90.130 · Cited by 136 · see citing works

Structural remodeling, trafficking and functions of glycosylphosphatidylinositol-anchored proteins

Maeda, Y., & Kinoshita, T. (2011) · Progress in Lipid Research · doi:10.1016/j.plipres.2011.05.002 · Cited by 106 · see citing works

Mechanism for Release of Alkaline Phosphatase Caused by Glycosylphosphatidylinositol Deficiency in Patients with Hyperphosphatasia Mental Retardation Syndrome

Murakami, Y., Kanzawa, N., Saito, K., Krawitz, P. M., Mundlos, S., Robinson, P. N., Karadimitris, A., Maeda, Y., & Kinoshita, T. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.331090 · Cited by 101 · see citing works

CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer

Guo, Z., Linn, J. F., Wu, G., Anzick, S. L., Eisenberger, C. F., Halachmi, S., Cohen, Y., Fomenkov, A. I., Hoque, M. O., Okami, K., et al. (2004) · Nature Medicine · doi:10.1038/nm1010 · Cited by 95 · see citing works

Monkeypox Virus Host Factor Screen Using Haploid Cells Identifies Essential Role of GARP Complex in Extracellular Virus Formation

Realegeno, S. E., Puschnik, A. S., Kumar, A., Goldsmith, C. S., Burgado, J., Sambhara, S. R., Olson, V. A., Carroll, D. S., Damon, I. K., Hirata, T., et al. (2017) · Journal of Virology · doi:10.1128/jvi.00011-17 · Cited by 93 · see citing works

Two Subunits of Glycosylphosphatidylinositol Transamidase, GPI8 and PIG-T, Form a Functionally Important Intermolecular Disulfide Bridge

Ohishi, K., Nagamune, K., Maeda, Y., & Kinoshita, T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300586200 · Cited by 83 · see citing works

PIG-V Involved in Transferring the Second Mannose in Glycosylphosphatidylinositol

Kang, J. Y., Hong, Y., Ashida, H., Shishioh, N., Murakami, Y., Morita, Y. S., Maeda, Y., & Kinoshita, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m413867200 · Cited by 82 · see citing works

Mammalian PIG-X and Yeast Pbn1p Are the Essential Components of Glycosylphosphatidylinositol-Mannosyltransferase I

Ashida, H., Hong, Y., Murakami, Y., Shishioh, N., Sugimoto, N., Kim, Y. U., Maeda, Y., & Kinoshita, T. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-09-0802 · Cited by 78 · see citing works

Mutational Analysis of the Glycosylphosphatidylinositol (GPI) Anchor Pathway Demonstrates that GPI-Anchored Proteins Are Required for Cell Wall Biogenesis and Normal Hyphal Growth inNeurospora crassa

Bowman, S. M., Piwowar, A., Aldabbous, M. S., Vierula, J., & Free, S. J. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.3.587-600.2006 · Cited by 78 · see citing works

Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer

Wu, G., Guo, Z., Chatterjee, A., Huang, X., Rubin, E., Wu, F., Mambo, E., Chang, X., Osada, M., Kim, M. S., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-0506 · Cited by 72 · see citing works

Organization of the Sec61 Translocon, Studied by High Resolution Native Electrophoresis

Dejgaard, K., Théberge, J.-F., Heath-Engel, H. M., Chevet, É., Tremblay, M. L., & Thomas, D. Y. (2010) · Journal of Proteome Research · doi:10.1021/pr900900x · Cited by 64 · see citing works

Profiling the expression pattern of GPI transamidase complex subunits in human cancer

Nagpal, J. K., Dasgupta, S., Jadallah, S., Chae, Y. K., Ratovitski, E. A., Toubaji, A., Netto, G. J., Eagle, T., Nissan, A., Sidransky, D., et al. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.76 · Cited by 64 · see citing works

GPI Transamidase and GPI anchored proteins: Oncogenes and biomarkers for cancer

Gamage, D. G., & Hendrickson, T. L. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.831024 · Cited by 63 · see citing works

Mutations in PIGU Impair the Function of the GPI Transamidase Complex, Causing Severe Intellectual Disability, Epilepsy, and Brain Anomalies

Knaus, A., Kortüm, F., Kleefstra, T., Stray‐Pedersen, A., Đukić, D., Murakami, Y., Gerstner, T. A., van Bokhoven, H., Iqbal, Z., Horn, D., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.06.009 · Cited by 60 · see citing works

Transamidase subunit GAA1/GPAA1 is a M28 family metallo-peptide-synthetase that catalyzes the peptide bond formation between the substrate protein’s omega-site and the GPI lipid anchor’s phosphoethanolamine

Eisenhaber, B., Eisenhaber, S., Toh, Y. K., Grüber, G., & Eisenhaber, F. (2014) · Cell Cycle · doi:10.4161/cc.28761 · Cited by 54 · see citing works

GPI transamidase of Trypanosoma brucei has two previously uncharacterized (trypanosomatid transamidase 1 and 2) and three common subunits

Nagamune, K., Ohishi, K., Ashida, H., Hong, Y., Hino, J., Kangawa, K., Inoue, N., Maeda, Y., & Kinoshita, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1833260100 · Cited by 54 · see citing works

Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation

Höchsmann, B., Murakami, Y., Osato, M., Knaus, A., Kawamoto, M., Inoue, N., Hirata, T., Murata, S., Anliker, M., Eggermann, T., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123501 · Cited by 48 · see citing works

A knockout cell library of GPI biosynthetic genes for functional studies of GPI-anchored proteins

Liu, S., Liu, Y., Guo, X., Murakami, Y., Yang, G., Gao, X., Kinoshita, T., & Fujita, M. (2021) · Communications Biology · doi:10.1038/s42003-021-02337-1 · Cited by 48 · see citing works

CHO Glycosylation Mutants: GPI Anchor

Maeda, Y., Ashida, H., & Kinoshita, T. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)16012-7 · Cited by 48 · see citing works

The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids

Borges, A. R., Link, F., Engstler, M., & Jones, N. G. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.720536 · Cited by 45 · see citing works

Glycosylphosphatidylinositol anchors regulate glycosphingolipid levels

Loizides‐Mangold, U., David, F. P. A., Nesatyy, V. J., Kinoshita, T., & Riezman, H. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m025692 · Cited by 45 · see citing works

Biogenesis of GPI-anchored proteins is essential for surface expression of sodium channels in zebrafish Rohon-Beard neurons to respond to mechanosensory stimulation

Nakano, Y., Fujita, M., Ogino, K., Saint‐Amant, L., Kinoshita, T., Oda, Y., & Hirata, H. (2010) · Development · doi:10.1242/dev.047464 · Cited by 43 · see citing works

Recent developments in the molecular, biochemical and functional characterization of GPI8 and the GPI-anchoring mechanism [Review]

Zacks, M. A., & Garg, N. J. (2006) · Molecular Membrane Biology · doi:10.1080/09687860600601494 · Cited by 40 · see citing works

Molecular insights into biogenesis of glycosylphosphatidylinositol anchor proteins

Xu, Y., Jia, G., Li, T., Zhou, Z., Luo, Y., Chao, Y., Bao, J., Su, Z., Qu, Q., & Li, D. (2022) · Nature Communications · doi:10.1038/s41467-022-30250-6 · Cited by 36 · see citing works

Structure of human glycosylphosphatidylinositol transamidase

Zhang, H., Su, J., Li, B., Gao, Y., Liu, M., He, L., Xu, H., Dong, Y., Zhang, X. C., & Zhao, Y. (2022) · Nature Structural & Molecular Biology · doi:10.1038/s41594-022-00726-6 · Cited by 35 · see citing works

A Conserved Proline in the Last Transmembrane Segment of Gaa1 Is Required for Glycosylphosphatidylinositol (GPI) Recognition by GPI Transamidase

Vainauskas, S., & Menon, A. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312191200 · Cited by 34 · see citing works

Free, unlinked glycosylphosphatidylinositols on mammalian cell surfaces revisited

Wang, Y., Hirata, T., Maeda, Y., Murakami, Y., Fujita, M., & Kinoshita, T. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.007472 · Cited by 34 · see citing works

Deficiencies in the Endoplasmic Reticulum (ER)-Membrane Protein Gab1p Perturb Transfer of Glycosylphosphatidylinositol to Proteins and Cause Perinuclear ER-associated Actin Bar Formation

Grimme, S. J., Gao, X., Martin, P. S., Tu, K., Cheperegin, S. E., Corrado, K., Farewell, A., Orlean, P., & Bi, E. (2004) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-01-0035 · Cited by 34 · see citing works

Generating anchors only to lose them: The unusual story of glycosylphosphatidylinositol anchor biosynthesis and remodeling in yeast and fungi

Komath, S. S., Singh, S. L., Pratyusha, V. A., & Sah, S. K. (2018) · IUBMB Life · doi:10.1002/iub.1734 · Cited by 32 · see citing works

Structures of liganded glycosylphosphatidylinositol transamidase illuminate GPI-AP biogenesis

Xu, Y., Li, T., Zhou, Z., Hong, J., Chao, Y., Zhu, Z., Zhang, Y., Qu, Q., & Li, D. (2023) · Nature Communications · doi:10.1038/s41467-023-41281-y · Cited by 32 · see citing works

The Link between Type 2 Diabetes Mellitus and the Polymorphisms of Glutathione-Metabolizing Genes Suggests a New Hypothesis Explaining Disease Initiation and Progression

Azarova, I. E., Klyosova, E. Y., & Polonikov, A. (2021) · Life · doi:10.3390/life11090886 · Cited by 30 · see citing works

Comparative Analysis of Protein Glycosylation Pathways in Humans and the Fungal PathogenCandida albicans

Martínez-Duncker, I., Díaz-Jiménez, D. F., & Mora-Montes, H. M. (2014) · International Journal of Microbiology · doi:10.1155/2014/267497 · Cited by 30 · see citing works

Bridging the GAPs in plant reproduction: a comparison of plant and animal GPI-anchored proteins

Desnoyer, N. J., & Palanivelu, R. (2020) · Plant Reproduction · doi:10.1007/s00497-020-00395-9 · Cited by 28 · see citing works

Trypanosome Glycosylphosphatidylinositol Biosynthesis

Hong, Y., & Kinoshita, T. (2009) · Korean Journal of Parasitology · doi:10.3347/kjp.2009.47.3.197 · Cited by 28 · see citing works

Screening for glycosylphosphatidylinositol-anchored proteins in the Paracoccidioides brasiliensis transcriptome.

Castro, N. D. S., Maia, Z. A., Pereira, M., & Soares, C. M. D. A. (2005) · PubMed · Cited by 25 · see citing works

Structural variation and fusion detection using targeted sequencing data from circulating cell free DNA

Gawronski, A., Lin, Y.-Y., McConeghy, B. J., LeBihan, S., Asghari, H., Koçkan, C., Orabi, B., Adra, N., Пили, Р., Collins, C. C., et al. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz067 · Cited by 24 · see citing works

Methods to Study GPI Anchoring of Proteins

Varma, Y., & Hendrickson, T. L. (2010) · ChemBioChem · doi:10.1002/cbic.200900704 · Cited by 24 · see citing works

Alterations of GPI transamidase subunits in head and neck squamous carcinoma

Jiang, W.-W., ZAHURAK, M. L., Zhou, Z., Park, H. L., Guo, Z., Wu, G.-J., Sidransky, D., Trink, B., & Califano, J. A. (2007) · Molecular Cancer · doi:10.1186/1476-4598-6-74 · Cited by 24 · see citing works

Gpi17p does not stably interact with other subunits of glycosylphosphatidylinositol transamidase in Saccharomyces cerevisiae

Zhu, Y., Fraering, P. C., Vionnet, C., & Conzelmann, A. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.05.001 · Cited by 23 · see citing works

Congenital Defects in the Expression of the Glycosylphosphatidylinositol-Anchored Complement Regulatory Proteins CD59 and Decay-Accelerating Factor

Kinoshita, T. (2018) · Seminars in Hematology · doi:10.1053/j.seminhematol.2018.04.004 · Cited by 21 · see citing works

PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape

Wei, X., Yang, W., Zhang, F., Cheng, F., Rao, J., & Lü, L. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118476 · Cited by 20 · see citing works

Function of a membrane-embedded domain evolutionarily multiplied in the GPI lipid anchor pathway proteins PIG-B, PIG-M, PIG-U, PIG-W, PIG-V, and PIG-Z

Eisenhaber, B., Sinha, S., Wong, W., & Eisenhaber, F. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1456294 · Cited by 20 · see citing works

PIGU overexpression adds value to TNM staging in the prognostic stratification of patients with hepatocellular carcinoma

Cao, J., Wang, P., Chen, J., & He, X. (2018) · Human Pathology · doi:10.1016/j.humpath.2018.08.013 · Cited by 20 · see citing works

Ethanolamine Phosphate Linked to the First Mannose Residue of Glycosylphosphatidylinositol (GPI) Lipids Is a Major Feature of the GPI Structure That Is Recognized by Human GPI Transamidase

Vainauskas, S., & Menon, A. K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m608896200 · Cited by 20 · see citing works

Truncation of the caspase-related subunit (Gpi8p) of Saccharomyces cerevisiae GPI transamidase: Dimerization revealed

Meitzler, J. L., Gray, J. J., & Hendrickson, T. L. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.035 · Cited by 18 · see citing works

Synthesis of Truncated Analogues for Studying the Process of Glycosyl Phosphatidylinositol Modification

John, F., & Hendrickson, T. L. (2010) · Organic Letters · doi:10.1021/ol100575q · Cited by 15 · see citing works

Structural insight into the glycosylphosphatidylinositol transamidase subunits PIG-K and PIG-S from yeast

Toh, Y. K., Kamariah, N., Maurer‐Stroh, S., Roessle, M. W., Eisenhaber, F., Adhikari, S., Eisenhaber, B., & Grüber, G. (2010) · Journal of Structural Biology · doi:10.1016/j.jsb.2010.11.026 · Cited by 14 · see citing works

Ethanolamine‐phosphate on the second mannose is a preferential bridge for some GPI‐anchored proteins

Ishida, M., Maki, Y., Ninomiya, A., Takada, Y. K., Campeau, P. M., Kinoshita, T., & Murakami, Y. (2022) · EMBO Reports · doi:10.15252/embr.202154352 · Cited by 14 · see citing works

Biochemical insights into the biodegradation mechanism of typical sulfonylureas herbicides and association with active enzymes and physiological response of fungal microbes: A multi-omics approach

Gao, Z., Gu, C., Fan, X., Shen, L., Jin, Z., Wang, F., & Jiang, X. (2024) · Environment International · doi:10.1016/j.envint.2024.108906 · Cited by 13 · see citing works

AtPIG-S, a predicted Glycosylphosphatidylinositol Transamidase subunit, is critical for pollen tube growth in Arabidopsis

Desnoyer, N. J., Howard, G., Jong, E., & Palanivelu, R. (2020) · BMC Plant Biology · doi:10.1186/s12870-020-02587-x · Cited by 13 · see citing works

Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT)

Yi, L., Bozkurt, G., Li, Q., Lo, S., Menon, A. K., & Wu, H. (2017) · Scientific Reports · doi:10.1038/srep45912 · Cited by 12 · see citing works

Glycosylphosphatidylinositol mannosyltransferase II is the rate-limiting enzyme in glycosylphosphatidylinositol biosynthesis under limited dolichol-phosphate mannose availability

Hirata, T., Fujita, M., Kanzawa, N., Murakami, Y., Maeda, Y., & Kinoshita, T. (2013) · The Journal of Biochemistry · doi:10.1093/jb/mvt045 · Cited by 12 · see citing works

High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis

Müller, C. S., Bildl, W., Klugbauer, N., Haupt, A., Fakler, B., & Schulte, U. (2019) · Journal of Visualized Experiments · doi:10.3791/60096 · Cited by 12 · see citing works

Overview and perspectives on the transcriptome of Paracoccidioides brasiliensis

de Andrade, R. V., da Silva, S. P., Torres, F. A. G., Poças-Fonseca, M. J., Silva-Pereira, I., Maranhão, A. Q., Campos, E. G., de Moraes, L. M. P., Jesuíno, R. S. A., Pereira, M., et al. (2005) · Revista Iberoamericana de Micología · doi:10.1016/s1130-1406(05)70044-9 · Cited by 12 · see citing works

Lipids and membranes

Schweizer, M. (2004) · CRC Press eBooks · doi:10.1201/9780203503867.ch6 · Cited by 12 · see citing works

Towards a thorough understanding of mammalian glycosylphosphatidylinositol-anchored protein biosynthesis

Kinoshita, T. (2024) · Glycobiology · doi:10.1093/glycob/cwae061 · Cited by 11 · see citing works

Endoplasmic Reticulum Localization of Gaa1 and PIG-T, Subunits of the Glycosylphosphatidylinositol Transamidase Complex

Vainauskas, S., & Menon, A. K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414253200 · Cited by 11 · see citing works

A step closer in defining glycosylphosphatidylinositol anchored proteins role in health and glycosylation disorders

Manea, E. (2018) · Molecular Genetics and Metabolism Reports · doi:10.1016/j.ymgmr.2018.07.006 · Cited by 10 · see citing works

Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila

Yamamoto‐Hino, M., Katsumata, E., Suzuki, E., Maeda, Y., Kinoshita, T., & Goto, S. (2018) · Journal of Cell Science · doi:10.1242/jcs.218024 · Cited by 10 · see citing works

A Soluble, Minimalistic Glycosylphosphatidylinositol Transamidase (GPI-T) Retains Transamidation Activity

Ness, T. J., Gamage, D. G., Ekanayaka, S. A., & Hendrickson, T. L. (2022) · Biochemistry · doi:10.1021/acs.biochem.2c00196 · Cited by 10 · see citing works

Overexpression of CDC91L1 (PIG‐U) in bladder urothelial cell carcinoma: correlation with clinical variables and prognostic significance

Shen, Y., Ye, D., Yao, X., Trink, B., Zhou, X., Zhang, S., Dai, B., Zhang, H., Zhu, Y., Guo, Z., et al. (2007) · British Journal of Urology · doi:10.1111/j.1464-410x.2007.07192.x · Cited by 10 · see citing works

Evidence of the milder phenotypic spectrum of c. 1582G >A PIGT variant: Delineation based on seven novel Polish patients

Jezela‐Stanek, A., Szczepanik, E., Mierzewska, H., Rydzanicz, M., Rutkowska, K., Knaus, A., Śmigiel, R. S., Stępniak, I., Markiewicz, M. G., Boniel, S., et al. (2020) · Clinical Genetics · doi:10.1111/cge.13822 · Cited by 10 · see citing works

Lipids and membranes

Dickinson, J. R., & Schweizer, M. (2004) · doi:10.1201/9780203503867-13 · Cited by 10 · see citing works

Biosynthesis of GPI anchored proteins, its deficiencies and treatment

Murakami, Y. (2025) · Journal of Human Genetics · doi:10.1038/s10038-025-01379-1 · Cited by 9 · see citing works

Low-resolution structure of the soluble domain GPAA1 (yGPAA170–247) of the glycosylphosphatidylinositol transamidase subunit GPAA1 from Saccharomyces cerevisiae

Saw, W. G., Eisenhaber, B., Eisenhaber, F., & Grüber, G. (2013) · Bioscience Reports · doi:10.1042/bsr20120107 · Cited by 9 · see citing works

The soluble domains of Gpi8 and Gaa1, two subunits of glycosylphosphatidylinositol transamidase (GPI-T), assemble into a complex

Gamage, D. G., Varma, Y., Meitzler, J. L., Morissette, R., Ness, T. J., & Hendrickson, T. L. (2017) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2017.09.006 · Cited by 8 · see citing works

The caspase-like Gpi8 subunit of Candida albicans GPI transamidase is a metal-dependent endopeptidase

Sah, S. K., Shefali, S., Yadav, A., Som, P., & Komath, S. S. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.02.008 · Cited by 8 · see citing works

Structure and Function of the Glycosylphosphatidylinositol Transamidase, a Transmembrane Complex Catalyzing GPI Anchoring of Proteins

Li, D. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-58843-3_16 · Cited by 8 · see citing works

Structural Changes of GPI Anchor After Its Attachment to Proteins: Functional Significance

Kinoshita, T. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-11280-0_2 · Cited by 8 · see citing works

Stability of the transamidase complex catalyzing GPI anchoring of proteins

Kawaguchi, K., Sato, T., Kondo, S., Yamamoto‐Hino, M., & Goto, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.03.103 · Cited by 8 · see citing works

Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding the active site

Su, C. T.-T., Sinha, S., Eisenhaber, B., & Eisenhaber, F. (2020) · Biology Direct · doi:10.1186/s13062-020-00266-3 · Cited by 8 · see citing works

Glycosylation editing: an innovative therapeutic opportunity in precision oncology

Dai, X., Yang, Y., & Yang, B.-Z. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-05033-w · Cited by 7 · see citing works

Inherited glycosylphosphatidylinositol deficiency: a review from molecular and clinical perspectives

Li, S., Tang, Q., Jiang, Y., & Chen, X. (2024) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2024128 · Cited by 7 · see citing works

Integrated analysis reveals an immune evasion prognostic signature for predicting the overall survival in patients with hepatocellular carcinoma

Wen, J., Wen, K., Meng, T., Zhou, Z., He, X., Wang, W., Huang, Z., Lin, Q., Li, H., Liu, H., et al. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03743-9 · Cited by 7 · see citing works

A novel nine gene signature integrates stemness characteristics associated with prognosis in hepatocellular carcinoma

Yao, X., Lu, C., Shen, J., Jiang, W., Qiu, Y., Zeng, Y., & Liang, L. (2021) · Biocell · doi:10.32604/biocell.2021.017289 · Cited by 7 · see citing works

Defining the boundaries of species specificity for the Saccharomyces cerevisiae glycosylphosphatidylinositol transamidase using a quantitative in vivo assay

Morissette, R., Varma, Y., & Hendrickson, T. L. (2012) · Bioscience Reports · doi:10.1042/bsr20120064 · Cited by 7 · see citing works

Potential Physiological Relevance of ERAD to the Biosynthesis of GPI-Anchored Proteins in Yeast

Nakatsukasa, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031061 · Cited by 7 · see citing works

New mutant Chinese hamster ovary cell representing an unknown gene for attachment of glycosylphosphatidylinositol to proteins

Hong, Y., Kang, J. Y., Kim, Y. U., Shin, D., Choy, H. E., Maeda, Y., & Kinoshita, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.177 · Cited by 6 · see citing works

Synthesis, Genetics, and Congenital Diseases of GPI-Anchored Proteins

Maeda, Y., Murakami, Y., & Kinoshita, T. (2017) · Springer eBooks · doi:10.1007/978-4-431-56003-6_2 · Cited by 5 · see citing works

Characterization of GPIT-1 and GPIT-2, two auxiliary components of theNeurospora crassaGPI transamidase complex

Bowman, S. M., Piwowar, A., Arnone, E. D., Matsumoto, R., Koudelka, G. B., & Free, S. J. (2009) · Mycologia · doi:10.3852/09-022 · Cited by 4 · see citing works

Subunits of the GPI transamidase complex localize to the endoplasmic reticulum and nuclear envelope in Drosophila

Kawaguchi, K., Yamamoto‐Hino, M., Matsuyama, N., Suzuki, E., & Goto, S. (2021) · FEBS Letters · doi:10.1002/1873-3468.14048 · Cited by 4 · see citing works

Hrd1-dependent Degradation of the Unassembled PIGK Subunit of the GPI Transamidase Complex

Kawaguchi, K., Yamamoto‐Hino, M., Murakami, Y., Kinoshita, T., & Goto, S. (2021) · Cell Structure and Function · doi:10.1247/csf.21019 · Cited by 4 · see citing works

Analysis of Complexome Profiles with the Gaussian Interaction Profiler (GIP) Reveals Novel Protein Complexes in Plasmodium falciparum

van Strien, J., Evers, F., Cabrera‐Orefice, A., Delhez, I., Kooij, T. W. A., & Huynen, M. A. (2024) · Journal of Proteome Research · doi:10.1021/acs.jproteome.4c00414 · Cited by 3 · see citing works

Purification and crystallization of yeast glycosylphosphatidylinositol transamidase subunit PIG-S (PIG-S71–467)

Kamariah, N., Eisenhaber, F., Adhikari, S., Eisenhaber, B., & Grüber, G. (2011) · Acta Crystallographica Section F Structural Biology and Crystallization Communications · doi:10.1107/s1744309111024080 · Cited by 3 · see citing works

Diseases Associated with GPI Anchors

Kinoshita, T., Murakami, Y., & Morita, Y. (2007) · Elsevier eBooks · doi:10.1016/b978-044451967-2/00102-1 · Cited by 3 · see citing works

High-Resolution Complexome Profiling by Cryoslicing BN-MS Analysis

Müller, C. S., Bildl, W., Klugbauer, N., Haupt, A., Fakler, B., & Schulte, U. (2019) · Journal of Visualized Experiments · doi:10.3791/60096-v · Cited by 3 · see citing works

Glycans of the Pathogenic Yeast Cryptococcus neoformans and Related Opportunities for Therapeutic Advances

Loza, L., & Doering, T. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819475-1.00079-1 · Cited by 2 · see citing works

Chapter 1 Overview of GPI Biosynthesis

Kinoshita, T., & Fujita, M. (2009) · The Enzymes · doi:10.1016/s1874-6047(09)26001-x · Cited by 2 · see citing works

Tobacco Smoke Activates Protein Association and Tyrosine Phosphorylation of the GPI-Transamidase Complex Subunits in Human Cancers

Huang, Y., Nagpal, J. K., Trink, B., & Ratovitski, E. A. (2009) · Journal of Epithelial Biology & Pharmacology · doi:10.2174/1875044300902010014 · Cited by 2 · see citing works

Characterization of phosphatidylinositol-glycan biosynthesis protein class F gene in rice

Lee, D. H., & Kang, S. G. (2008) · DNA sequence · doi:10.1080/10425170701575364 · Cited by 1 · see citing works

Sequence based analysis of U-2973, a cell line established from a double-hit B-cell lymphoma with concurrent MYC and BCL2 rearrangements

Hooper, S. D., Jiao, X., Sundström, E., Rehman, F. L., Tellgren‐Roth, C., Sjöblom, T., & Cavelier, L. B. (2012) · BMC Research Notes · doi:10.1186/1756-0500-5-648 · Cited by 1 · see citing works

Use of Clostridium septicum alpha toxins for isolation of various glycosylphosphatidylinositol-deficient cells.

Shin, D., Choy, H. E., & Hong, Y. (2005) · PubMed · Cited by 1 · see citing works

PIG‐S and PIG‐T, essential for GPI anchor attachment to proteins, form a complex with GAA1 and GPI8

Ohishi, K., Inoue, N., & Kinoshita, T. (2001) · The EMBO Journal · doi:10.1093/emboj/20.15.4088 · Cited by 177 · see citing works

Gaa1p and Gpi8p Are Components of a Glycosylphosphatidylinositol (GPI) Transamidase That Mediates Attachment of GPI to Proteins

Ohishi, K., Inoue, N., Maeda, Y., Takeda, J., Riezman, H., & Kinoshita, T. (2000) · Molecular Biology of the Cell · doi:10.1091/mbc.11.5.1523 · Cited by 126 · see citing works

The glycosylphosphatidylinositol (GPI) signal sequence of human placental alkaline phosphatase is not recognized by human Gpi8p in the context of the yeast GPI anchoring machinery

Meyer, U., Fraering, P. C., Bosson, R., Imhof, I., Benghezal, M., Vionnet, C., & Conzelmann, A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03192.x · Cited by 7 · see citing works

Yeast Gaa1p is required for attachment of a completed GPI anchor onto proteins.

Hamburger, D., Egerton, M., & Riezman, H. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.3.629 · Cited by 172 · see citing works

Structure and Function of the Glycosylphosphatidylinositol Transamidase, a Transmembrane Complex Catalyzing GPI Anchoring of Proteins

Li, D. (2024) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-3-031-58843-3_16 · Cited by 8 · see citing works