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Cited by 316

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Variation in Gene Expression Patterns in Human Gastric Cancers

Open access
Chen, Xin, Leung, Suet Y., Yuen, Siu T., Chu, Kent-Man, Ji, Jiafu, Li, Rui, Chan, Annie S.Y., Law, Simon, Troyanskaya, Olga G., Wong, John, So, Samuel, Botstein, David, Brown, Patrick O.·2003·Molecular Biology of the Cell

Abstract

Gastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.

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Metadata

Authors
Chen, X., Leung, S. Y., Yuen, S. T., Chu, K.-M., Ji, J., Li, R., Chan, A. S. Y., Law, S., Troyanskaya, O. G., Wong, J., So, S., Botstein, D., & Brown, P. O.
Venue
Molecular Biology of the Cell
Published
2003-08
Volume
14
Issue
8
Pages
3208-3215
ISSN
  • 1059-1524 (ISSN-L)
  • 1939-4586
OpenAlex
W2109986840
Cited by
316
References
1
FWCI
12.26
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Variation in Gene Expression Patterns in Human Gastric Cancers. https://app.cochat.ai/papers/10.1091/mbc.e02-12-0833
The paper
Chen, X., Leung, S. Y., Yuen, S. T., Chu, K.-M., Ji, J., Li, R., Chan, A. S. Y., Law, S., Troyanskaya, O. G., Wong, J., So, S., Botstein, D., & Brown, P. O. (2003). Variation in Gene Expression Patterns in Human Gastric Cancers. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e02-12-0833

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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