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Variation in Gene Expression Patterns in Human Gastric Cancers
Open accessAbstract
Gastric cancer is the world's second most common cause of cancer death. We analyzed gene expression patterns in 90 primary gastric cancers, 14 metastatic gastric cancers, and 22 nonneoplastic gastric tissues, using cDNA microarrays representing ∼30,300 genes. Gastric cancers were distinguished from nonneoplastic gastric tissues by characteristic differences in their gene expression patterns. We found a diversity of gene expression patterns in gastric cancer, reflecting variation in intrinsic properties of tumor and normal cells and variation in the cellular composition of these complex tissues. We identified several genes whose expression levels were significantly correlated with patient survival. The variations in gene expression patterns among cancers in different patients suggest differences in pathogenetic pathways and potential therapeutic strategies.
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Gene expression profiling predicts clinical outcome of breast cancer
van 't Veer, L. J., Dai, H., van de Vijver, M. J., He, Y. D., Hart, A. A. M., Mao, M., Peterse, H. L., van der Kooy, K., Marton, M. J., Witteveen, A. T., et al. (2002) · Nature · doi:10.1038/415530a · Cited by 9,536
Cited by
Molecular analysis of gastric cancer identifies subtypes associated with distinct clinical outcomes
Cristescu, R., Lee, J., Nebozhyn, M., Kim, K.-M., Ting, J. C., Wong, S. S., Liu, J., Yue, Y. G., Wang, J., Yu, K., et al. (2015) · Nature Medicine · doi:10.1038/nm.3850 · Cited by 2,223
Wang, K., Yuen, S. T., Xu, J., Lee, S. P., Yan, H. H. N., Shi, S. T., Siu, H. C., Deng, S., Chu, K. M., Law, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.2983 · Cited by 1,045
Self-citationYan, H. H. N., Siu, H. C., Law, S., Ho, S. L., Yue, S. S. K., Tsui, W. Y., Chan, D., Chan, A. S., Ma, S., Lam, K. O., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.09.016 · Cited by 724
Self-citationDifferential coexpression analysis using microarray data and its application to human cancer
Choi, J. K., Yu, U., Yoo, O. J., & Kim, S. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti722 · Cited by 265
HMGA2 as a Critical Regulator in Cancer Development
Mansoori, B., Mohammadi, A., Ditzel, H. J., Duijf, P. H. G., Khaze, V., Gjerstorff, M. F., & Baradaran, B. (2021) · Genes · doi:10.3390/genes12020269 · Cited by 201
Metadata
- Authors
- Chen, X., Leung, S. Y., Yuen, S. T., Chu, K.-M., Ji, J., Li, R., Chan, A. S. Y., Law, S., Troyanskaya, O. G., Wong, J., So, S., Botstein, D., & Brown, P. O.
- Venue
- Molecular Biology of the Cell
- Published
- 2003-08
- Volume
- 14
- Issue
- 8
- Pages
- 3208-3215
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2109986840
- Cited by
- 316
- References
- 1
- FWCI
- 12.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Chen, X., Leung, S. Y., Yuen, S. T., Chu, K.-M., Ji, J., Li, R., Chan, A. S. Y., Law, S., Troyanskaya, O. G., Wong, J., So, S., Botstein, D., & Brown, P. O. (2003). Variation in Gene Expression Patterns in Human Gastric Cancers. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e02-12-0833
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