The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Spatial and Temporal Regulation of Condensins I and II in Mitotic Chromosome Assembly in Human Cells
Open accessAbstract
Two different condensin complexes make distinct contributions to metaphase chromosome architecture in vertebrate cells. We show here that the spatial and temporal distributions of condensins I and II are differentially regulated during the cell cycle in HeLa cells. Condensin II is predominantly nuclear during interphase and contributes to early stages of chromosome assembly in prophase. In contrast, condensin I is sequestered in the cytoplasm from interphase through prophase and gains access to chromosomes only after the nuclear envelope breaks down in prometaphase. The two complexes alternate along the axis of metaphase chromatids, but they are arranged into a unique geometry at the centromere/kinetochore region, with condensin II enriched near the inner kinetochore plate. This region-specific distribution of condensins I and II is severely disrupted upon depletion of Aurora B, although their association with the chromosome arm is not. Depletion of condensin subunits causes defects in kinetochore structure and function, leading to aberrant chromosome alignment and segregation. Our results suggest that the two condensin complexes act sequentially to initiate the assembly of mitotic chromosomes and that their specialized distribution at the centromere/kinetochore region may play a crucial role in placing sister kinetochores into the back-to-back orientation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456
Small Molecule Inhibitor of Mitotic Spindle Bipolarity Identified in a Phenotype-Based Screen
Mayer, T. U., Kapoor, T. M., Haggarty, S. J., King, R. W., Schreiber, S. L., & Mitchison, T. J. (1999) · Science · doi:10.1126/science.286.5441.971 · Cited by 1,727
Hauf, S., Cole, R. W., LaTerra, S., Zimmer, C., Schnapp, G., Walter, R., Heckel, A., van Meel, J., Rieder, C. L., & Peters, J.-M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200208092 · Cited by 1,155
The cellular geography of Aurora kinases
Carmena, M., & Earnshaw, W. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1245 · Cited by 1,139
Pines, J., & Hunter, T. (1991) · The Journal of cell biology · doi:10.1083/jcb.115.1.1 · Cited by 858
Giet, R., & Glover, D. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.152.4.669 · Cited by 623
Cimini, D., Howell, B., Maddox, P., Khodjakov, A., Degrassi, F., & Salmon, E. D. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.517 · Cited by 568
Ono, T., Losada, A., Hirano, M., Myers, M. P., Neuwald, A. F., & Hirano, T. (2003) · Cell · doi:10.1016/s0092-8674(03)00724-4 · Cited by 550
Self-citationSegregating Sister Genomes: The Molecular Biology of Chromosome Separation
Nasmyth, K. (2002) · Science · doi:10.1126/science.1074757 · Cited by 549
Hirano, T., Kobayashi, R., & Hirano, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80233-0 · Cited by 540
Self-citation
Cited by
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
Carmena, M., Wheelock, M., Funabiki, H., & Earnshaw, W. C. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3474 · Cited by 905
A pathway for mitotic chromosome formation
Gibcus, J. H., Samejima, K., Goloborodko, A., Samejima, I., Naumova, N., Nuebler, J., Kanemaki, M. T., Xie, L., Paulson, J. R., Earnshaw, W. C., et al. (2018) · Science · doi:10.1126/science.aao6135 · Cited by 744
Gandhi, R., Gillespie, P. J., & Hirano, T. (2006) · Current Biology · doi:10.1016/j.cub.2006.10.061 · Cited by 441
Self-citationThe Aurora kinase family in cell division and cancer
Vader, G., & Lens, S. M. A. (2008) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2008.07.003 · Cited by 417
Condensins: Organizing and Segregating the Genome
Hirano, T. (2005) · Current Biology · doi:10.1016/j.cub.2005.03.037 · Cited by 269
Self-citation
Metadata
- Authors
- Ono, T., Fang, Y., Spector, D. L., & Hirano, T.
- Venue
- Molecular Biology of the Cell
- Published
- 2004-07
- Volume
- 15
- Issue
- 7
- Pages
- 3296-3308
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2142308337
- Cited by
- 379
- References
- 61
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Spatial and Temporal Regulation of Condensins I and II in Mitotic Chromosome Assembly in Human Cells. https://app.cochat.ai/papers/10.1091/mbc.e04-03-0242
- The paper
- Ono, T., Fang, Y., Spector, D. L., & Hirano, T. (2004). Spatial and Temporal Regulation of Condensins I and II in Mitotic Chromosome Assembly in Human Cells. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e04-03-0242
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
