The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis
Open accessAbstract
Successful cell division requires the precise and timely coordination of chromosomal, cytoskeletal and membrane trafficking events. These processes are regulated by the competing actions of protein kinases and phosphatases. Aurora B is one of the most intensively studied kinases. In conjunction with inner centromere protein (INCENP), borealin (also known as Dasra) and survivin it forms the chromosomal passenger complex (CPC). This complex targets to different locations at differing times during mitosis, where it regulates key mitotic events: correction of chromosome–microtubule attachment errors; activation of the spindle assembly checkpoint; and construction and regulation of the contractile apparatus that drives cytokinesis. Our growing understanding of the CPC has seen it develop from a mere passenger riding on the chromosomes to one of the main controllers of mitosis.
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Citations
Cites
Shared and separate functions of polo-like kinases and aurora kinases in cancer
Lens, S. M. A., Voest, E. E., & Medema, R. H. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2964 · Cited by 597
Sensing centromere tension: Aurora B and the regulation of kinetochore function
Lampson, M. A., & Cheeseman, I. M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.10.007 · Cited by 375
Cytokinesis: Welcome to the Rho zone
Piekny, A., Werner, M., & Glotzer, M. (2005) · Trends in Cell Biology · doi:10.1016/j.tcb.2005.10.006 · Cited by 365
Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation
Kurasawa, Y., Earnshaw, W. C., Mochizuki, Y., Dohmae, N., & Todokoro, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600347 · Cited by 333
Self-citationFoley, E. A., Maldonado, M., & Kapoor, T. M. (2011) · Nature Cell Biology · doi:10.1038/ncb2327 · Cited by 267
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
Ramadan, K., Bruderer, R., Spiga, F. M., Popp, O., Baur, T., Gotta, M., & Meyer, H. H. (2007) · Nature · doi:10.1038/nature06388 · Cited by 261
Tanenbaum, M. E., Macurek, L., van der Vaart, B., Galli, M., Akhmanova, A., & Medema, R. H. (2011) · Current Biology · doi:10.1016/j.cub.2011.07.017 · Cited by 148
Phosphorylation of mammalian Sgo2 by Aurora B recruits PP2A and MCAK to centromeres
Tanno, Y., Kitajima, T. S., Honda, T., Ando, Y., Ishiguro, K.-I., & Watanabe, Y. (2010) · Genes & Development · doi:10.1101/gad.1945310 · Cited by 139
Cited by
The molecular biology of spindle assembly checkpoint signaling dynamics.
Musacchio, A. (2015) · Current Biology · doi:10.1016/j.cub.2015.08.051 · Cited by 778
Effect of Mutation Order on Myeloproliferative Neoplasms
Ortmann, C. A., Kent, D. G., Nangalia, J., Silber, Y., Wedge, D. C., Grinfeld, J., Baxter, E. J., Massie, C. E., Papaemmanuil, E., Menon, S., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1412098 · Cited by 562
Genome-Informed Targeted Therapy for Osteosarcoma
Sayles, L. C., Breese, M. R., Koehne, A. L., Leung, S. G., Lee, A. G., Liu, H.-Y., Spillinger, A., Shah, A. T., Tanasa, B., Straessler, K., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-17-1152 · Cited by 452
“Genome-Informed Targeting of AURKB AURKB is part of the chromosomal passenger complex and is a key regulator of mitosis (43).”
BackgroundA Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader
Huang, H.-T., Dobrovolsky, D., Paulk, J., Yang, G., Weisberg, E. L., Doctor, Z. M., Buckley, D. L., Cho, J.-H., Ko, E., Jang, J., et al. (2018) · Cell Chemical Biology · doi:10.1016/j.chembiol.2017.10.005 · Cited by 437
Aurora kinases: novel therapy targets in cancers
Tang, A., Gao, K., Chu, L., Zhang, R., Yang, J., & Zheng, J. (2017) · Oncotarget · doi:10.18632/oncotarget.14893 · Cited by 382
Metadata
- Authors
- Carmena, M., Wheelock, M., Funabiki, H., & Earnshaw, W. C.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2012-11-23
- Volume
- 13
- Issue
- 12
- Pages
- 789-803
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2050723856
- Cited by
- 905
- References
- 8
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Carmena, M., Wheelock, M., Funabiki, H., & Earnshaw, W. C. (2012). The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm3474
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