CoChat
Sign Up
Cited by 155Bone Metabolism and DiseasesCell Adhesion Molecules ResearchBone and Dental Protein Studies

The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.

CD44 and β3 Integrin Organize Two Functionally Distinct Actin-based Domains in Osteoclasts

Open access
Chabadel, Anne, Bañon-Rodríguez, Inmaculada, Cluet, David, Rudkin, Brian B., Wehrle-Haller, Bernhard, Genot, Elisabeth, Jurdic, Pierre, Anton, Ines M., Saltel, Frédéric·2007·Molecular Biology of the Cell
DOI 10.1091/mbc.e07-04-0378PMC PMC2096584
Open this paper in CoChat — free account

Abstract

The actin cytoskeleton of mature osteoclasts (OCs) adhering to nonmineralized substrates is organized in a belt of podosomes reminiscent of the sealing zone (SZ) found in bone resorbing OCs. In this study, we demonstrate that the belt is composed of two functionally different actin-based domains: podosome cores linked with CD44, which are involved in cell adhesion, and a diffuse cloud associated with β3 integrin, which is involved in cell adhesion and contraction. Wiskott Aldrich Syndrome Protein (WASp) Interacting Protein (WIP)−/− OCs were devoid of podosomes, but they still exhibited actin clouds. Indeed, WIP−/− OCs show diminished expression of WASp, which is required for podosome formation. CD44 is a novel marker of OC podosome cores and the first nonintegrin receptor detected in these structures. The importance of CD44 is revealed by showing that its clustering restores podosome cores and WASp expression in WIP−/− OCs. However, although CD44 signals are sufficient to form a SZ, the presence of WIP is indispensable for the formation of a fully functional SZ.

Overview

Integrity signals

Registry

Crossref · 10.1091/mbc.e07-04-0378

Cites

58 of 58 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 2

  1. Linder S., 2007, Trends Cell Biol, 17, 107, 10.1016/j.tcb.2007.01.002 · DOI
  2. Mizutani K., 2002, Cancer Res, 62, 669

Cited by

Sorted by citations

See all 155

Related

See all

Metadata

Authors
Chabadel, A., Bañon-Rodríguez, I., Cluet, D., Rudkin, B. B., Wehrle-Haller, B., Genot, E., Jurdic, P., Anton, I. M., & Saltel, F.
Affiliations
  • Lyon 1 Université (FR)
  • Centro de Biología Molecular “Severo Ochoa,” Consejo Superior de Investigaciones Cientificas-Universidad Autonoma de Madrid, 28049 Madrid, Spain;
  • Department of Cellular Physiology and Metabolism, Centre Médical Universitaire, 1211 Geneva 4, Switzerland; and
  • Inserm (FR)
  • Consejo Superior de Investigaciones Científicas (ES)
ORCID
Venue
Molecular Biology of the Cell
Publisher
American Society for Cell Biology (ASCB)
Published
2007-12
Volume
18
Issue
12
Pages
4899-4910
ISSN
  • 1059-1524 (ISSN-L)
  • 1939-4586
DOI
10.1091/mbc.e07-04-0378
PMC
PMC2096584
OpenAlex
W2160358447
Cited by
154
References
57
Citations by year
2026: 1 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 9 · 2021: 6 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 3 · 2016: 8 · 2015: 8 · 2014: 11 · 2013: 7 · 2012: 11
FWCI
4.24
Type
journal article
Language
en
Open access
Locations
  • Molecular Biology of the Cell (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
  • HAL (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
European Social Fund
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
Keywords
osteoclasts, CD44, CD61, actin cytoskeleton, podosomes, sealing zone, WIP, wasps, cell adhesion, bone resorption, receptor clustering
MeSH terms
Actins, Animals, Bone Resorption, Intracellular Membranes, Osteoclasts, Signal Transduction, Mice, Knockout, Hyaluronan Receptors, Integrin beta3, Wiskott-Aldrich Syndrome Protein, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review