The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Role of Myosin II in Glioma Invasion of the Brain
Open accessAbstract
The ability of gliomas to invade the brain limits the efficacy of standard therapies. In this study, we have examined glioma migration in living brain tissue by using two novel in vivo model systems. Within the brain, glioma cells migrate like nontransformed, neural progenitor cells—extending a prominent leading cytoplasmic process followed by a burst of forward movement by the cell body that requires myosin II. In contrast, on a two-dimensional surface, glioma cells migrate more like fibroblasts, and they do not require myosin II to move. To explain this phenomenon, we studied glioma migration through a series of synthetic membranes with defined pore sizes. Our results demonstrate that the A and B isoforms of myosin II are specifically required when a glioma cell has to squeeze through pores smaller than its nuclear diameter. They support a model in which the neural progenitor-like mode of glioma invasion and the requirement for myosin II represent an adaptation needed to move within the brain, which has a submicrometer effective pore size. Furthermore, the absolute requirement for myosin II in brain invasion underscores the importance of this molecular motor as a potential target for new anti-invasive therapies to treat malignant brain tumors.
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Bubb, M. R., Senderowicz, A. M., Sausville, E. A., Duncan, K. L., & Korn, E. D. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)36545-6 · Cited by 811
Thorne, R. G., & Nicholson, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509425103 · Cited by 641
Control of nonmuscle myosins by phosphorylation
Tan, J. L., Ravid, S., & Spudich, J. A. (1992) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.61.070192.003445 · Cited by 353
Cited by
Wolf, K., te Lindert, M., Krause, M., Alexander, S., te Riet, J., Willis, A. L., Hoffman, R. M., Figdor, C. G., Weiss, S. J., & Friedl, P. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201210152 · Cited by 1,375
Molecular Identity of Human Outer Radial Glia during Cortical Development
Pollen, A. A., Nowakowski, T. J., Chen, J., Retallack, H., Sandoval-Espinosa, C., Nicholas, C. R., Shuga, J., Liu, S. J., Oldham, M. C., Diaz, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.09.004 · Cited by 908
Outer Radial Glia-like Cancer Stem Cells Contribute to Heterogeneity of Glioblastoma
Bhaduri, A., Di Lullo, E., Jung, D., Müller, S., Crouch, E. E., Espinosa, C. S., Ozawa, T., Alvarado, B., Spatazza, J., Cadwell, C. R., et al. (2020) · Cell Stem Cell · doi:10.1016/j.stem.2019.11.015 · Cited by 419
Interstitial guidance of cancer invasion
G. Gritsenko, P., Ilina, O., & Friedl, P. (2012) · The Journal of Pathology · doi:10.1002/path.3031 · Cited by 349
Shifting the optimal stiffness for cell migration
Bangasser, B. L., Shamsan, G. A., Chan, C. E., Opoku, K. N., Tüzel, E., Schlichtmann, B. W., Kasim, J. A., Fuller, B. J., McCullough, B. R., Rosenfeld, S. S., et al. (2017) · Nature Communications · doi:10.1038/ncomms15313 · Cited by 328
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Metadata
- Authors
- Beadle, C., Assanah, M. C., Monzo, P., Vallee, R., Rosenfeld, S. S., & Canoll, P.
- Venue
- Molecular Biology of the Cell
- Published
- 2008-08
- Volume
- 19
- Issue
- 8
- Pages
- 3357-3368
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2074812494
- Cited by
- 310
- References
- 3
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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