The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Shifting the optimal stiffness for cell migration
Open accessAbstract
Cell migration, which is central to many biological processes including wound healing and cancer progression, is sensitive to environmental stiffness, and many cell types exhibit a stiffness optimum, at which migration is maximal. Here we present a cell migration simulator that predicts a stiffness optimum that can be shifted by altering the number of active molecular motors and clutches. This prediction is verified experimentally by comparing cell traction and F-actin retrograde flow for two cell types with differing amounts of active motors and clutches: embryonic chick forebrain neurons (ECFNs; optimum ∼1 kPa) and U251 glioma cells (optimum ∼100 kPa). In addition, the model predicts, and experiments confirm, that the stiffness optimum of U251 glioma cell migration, morphology and F-actin retrograde flow rate can be shifted to lower stiffness by simultaneous drug inhibition of myosin II motors and integrin-mediated adhesions.
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Cites
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Cited by
Effects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224
Integrins as biomechanical sensors of the microenvironment
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“Past work focused on U251 glioma cancer cells measured a random motion coefficient (akin to diffusivity measured for a single cell) of between 60 and 300 𝜇 m 2 / hr across a range of substrate stiffnesses [51].”
Trusting the forces of our cell lines
Moro-López, M., Farré, R., Otero, J., & Sunyer, R. (2024) · Cells & Development · doi:10.1016/j.cdev.2024.203931 · Cited by 2
Metadata
- Authors
- Bangasser, B. L., Shamsan, G. A., Chan, C. E., Opoku, K. N., Tüzel, E., Schlichtmann, B. W., Kasim, J. A., Fuller, B. J., McCullough, B. R., Rosenfeld, S. S., & Odde, D. J.
- Venue
- Nature Communications
- Published
- 2017-05-22
- Volume
- 8
- Issue
- 1
- Pages
- 15313-15313
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2619683448
- Cited by
- 328
- References
- 30
- FWCI
- 11.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bangasser, B. L., Shamsan, G. A., Chan, C. E., Opoku, K. N., Tüzel, E., Schlichtmann, B. W., Kasim, J. A., Fuller, B. J., McCullough, B. R., Rosenfeld, S. S., & Odde, D. J. (2017). Shifting the optimal stiffness for cell migration. Nature Communications. https://doi.org/10.1038/ncomms15313
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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