Mitofusins and OPA1 Mediate Sequential Steps in Mitochondrial Membrane Fusion

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development

Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601

OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

Frezza, C., Cipolat, S., Martins de Brito, O., Micaroni, M., Beznoussenko, G. V., Rudka, T., Bartoli, D., Polishuck, R. S., Danial, N. N., De Strooper, B., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.025 · Cited by 1,673

A Photoactivatable GFP for Selective Photolabeling of Proteins and Cells

Patterson, G. H., & Lippincott‐Schwartz, J. (2002) · Science · doi:10.1126/science.1074952 · Cited by 1,612

Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A

Züchner, S., Mersiyanova, I. V., Muglia, M., Bissar-Tadmouri, N., Rochelle, J., Dadali, E. L., Zappia, M., Nelis, E., Patitucci, A., Senderek, J., et al. (2004) · Nature Genetics · doi:10.1038/ng1341 · Cited by 1,572

Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy

Delettre, C., Lenaers, G., Griffoin, J.-M., Gigarel, N., Lorenzo, C., Belenguer, P., Pelloquin, L., Grosgeorge, J., Turc-Carel, C., Perret, E., et al. (2000) · Nature Genetics · doi:10.1038/79936 · Cited by 1,446

Disruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction

Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376

Functions and dysfunctions of mitochondrial dynamics

Detmer, S. A., & Chan, D. C. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2275 · Cited by 1,369

OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28

Alexander, C., Votruba, M., Pesch, U. E. A., Thiselton, D. L., Mayer, S., Moore, A., Rodriguez, M., Kellner, U., Leo-Kottler, B., Auburger, G., et al. (2000) · Nature Genetics · doi:10.1038/79944 · Cited by 1,330

OPA1 requires mitofusin 1 to promote mitochondrial fusion

Cipolat, S., de Brito, O. M., Dal Zilio, B., & Scorrano, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407043101 · Cited by 1,300

Mitochondrial dynamics and apoptosis

Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

Olichon, A., Baricault, L., Gas, N., Guillou, E., Valette, A., Belenguer, P., & Lenaers, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200677200 · Cited by 1,168

Mitochondrial Fusion and Fission in Mammals

Chan, D. C. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104638 · Cited by 972

Mitochondrial fusion protects against neurodegeneration in the cerebellum

Chen, H., McCaffery, J. M., & Chan, D. C. (2007) · Cell · doi:10.1016/j.cell.2007.06.026 · Cited by 924

Structural Basis of Mitochondrial Tethering by Mitofusin Complexes

Koshiba, T., Detmer, S. A., Kaiser, J. T., Chen, H., McCaffery, J. M., & Chan, D. C. (2004) · Science · doi:10.1126/science.1099793 · Cited by 910

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

Song, Z., Chen, H., Fiket, M., Alexander, C., & Chan, D. C. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200704110 · Cited by 818

SLP‐2 is required for stress‐induced mitochondrial hyperfusion

Tondera, D., Grandemange, S., Jourdain, A. A., Karbowski, M., Mattenberger, Y., Herzig, S., Cruz, S. D., Clerc, P., Lauria, I., Merkwirth, C., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.89 · Cited by 796

The Machines that Divide and Fuse Mitochondria

Hoppins, S., Lackner, L., & Nunnari, J. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.071905.090048 · Cited by 790

Mitochondrial Morphology and Dynamics in Yeast and Multicellular Eukaryotes

Okamoto, K., & Shaw, J. M. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.093019 · Cited by 737

Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondriaPreprint

Merkwirth, C., Dargazanli, S., Tatsuta, T., Geimer, S., Löwer, B., Wunderlich, F. T., von Kleist-Retzow, J., Waisman, A., Westermann, B., & Langer, T. (2008) · Genes & Development · doi:10.1101/gad.460708 · Cited by 535

Mitochondrial Inner-Membrane Fusion and Crista Maintenance Requires the Dynamin-Related GTPase Mgm1

Meeusen, S., DeVay, R. M., Block, J., Cassidy-Stone, A., Wayson, S. M., McCaffery, J. M., & Nunnari, J. M. (2006) · Cell · doi:10.1016/j.cell.2006.09.021 · Cited by 474

Loss of the Intermembrane Space Protein Mgm1/OPA1 Induces Swelling and Localized Constrictions along the Lengths of Mitochondria

Griparić, L., van der Wel, N. N., Orozco, I. J., Peters, P. J., & van der Bliek, A. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400920200 · Cited by 468

Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function

Davies, V. J., Hollins, A. J., Piechota, M. J., Yip, W., Davies, J. R., White, K. E., Nicols, P. P., Boulton, M. E., & Votruba, M. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm079 · Cited by 449

Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis

Karbowski, M., Arnoult, D., Chen, H., Chan, D. C., Smith, C. L., & Youle, R. J. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200309082 · Cited by 433

Mutation of OPA1 causes dominant optic atrophy with external ophthalmoplegia, ataxia, deafness and multiple mitochondrial DNA deletions: a novel disorder of mtDNA maintenance

Hudson, G., Amati-Bonneau, P., Blakely, E. L., Stewart, J. D., He, L., Schaefer, A. M., Griffiths, P. G., Ahlqvist, K., Suomalainen, A., Reynier, P., et al. (2008) · Brain · doi:10.1093/brain/awm272 · Cited by 428

OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion

Zanna, C., Ghelli, A. M., Porcelli, A. M., Karbowski, M., Youle, R. J., Schimpf, S., Wissinger, B., Pinti, M., Cossarizza, A., Vidoni, S., et al. (2007) · Brain · doi:10.1093/brain/awm335 · Cited by 334

Correlated three-dimensional light and electron microscopy reveals transformation of mitochondria during apoptosis

Sun, M., Williams, J. M., Muñoz‐Pinedo, C., Perkins, G. A., Brown, J. M., Ellisman, M. H., Green, D. R., & Frey, T. (2007) · Nature Cell Biology · doi:10.1038/ncb1630 · Cited by 279

A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy

Alavi, M. V., Bette, S. J., Schimpf, S., Schuettauf, F., Schraermeyer, U., Wehrl, H. F., Rüttiger, L., Beck, S. C., Tonagel, F., Pichler, B. J., et al. (2006) · Brain · doi:10.1093/brain/awm005 · Cited by 278

Mgm1p, a Dynamin-related GTPase, Is Essential for Fusion of the Mitochondrial Outer Membrane

Sesaki, H., Southard, S. M., Yaffe, M. P., & Jensen, R. E. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-12-0788 · Cited by 274

The intramitochondrial dynamin-related GTPase, Mgm1p, is a component of a protein complex that mediates mitochondrial fusion

Wong, E. D., Wagner, J. A., Scott, S. V., Okreglak, V., Holewinske, T. J., Cassidy-Stone, A., & Nunnari, J. M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200209015 · Cited by 255

Separate fusion of outer and inner mitochondrial membranes

Malka, F., Guillery, O., Cifuentes-Díaz, C., Guillou, E., Belenguer, P., Lombès, A., & Rojo, M. (2005) · EMBO Reports · doi:10.1038/sj.embor.7400488 · Cited by 233

Ugo1p Links the Fzo1p and Mgm1p GTPases for Mitochondrial Fusion

Sesaki, H., & Jensen, R. E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401363200 · Cited by 198

Recruitment of an alternatively spliced form of synaptojanin 2 to mitochondria by the interaction with the PDZ domain of a mitochondrial outer membrane protein

Nemoto, Y., & Camilli, P. V. D. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.2991 · Cited by 195

OPA1 (Kjer Type) Dominant Optic Atrophy: A Novel Mitochondrial Disease

Delettre, C., Lenaers, G., Pelloquin, L., Belenguer, P., & Hamel, C. (2002) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2001.3278 · Cited by 191

Mitochondrial outer and inner membrane fusion requires a modified carrier protein

Hoppins, S. C., Horner, J. S., Song, C., McCaffery, J. M., & Nunnari, J. M. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200809099 · Cited by 99

Molecular Genetics of Autosomal-Dominant Axonal Charcot-Marie-Tooth Disease

Zuchner, S. L., & Vance, J. M. (2006) · NeuroMolecular Medicine · doi:10.1385/nmm:8:1-2:63 · Cited by 79

OPA1 mutations and mitochondrial DNA damage: keeping the magic circle in shape

Zeviani, M. (2008) · Brain · doi:10.1093/brain/awm339 · Cited by 41

Conventional and Immunoelectron Microscopy of Mitochondria

Perkins, E. M., & McCaffery, J. M. (2007) · Methods in molecular biology · doi:10.1007/978-1-59745-365-3_33 · Cited by 34

PA‐GFP: A Window into the Subcellular Adventures of the Individual Mitochondrion

Haigh, S. E., Twig, G., Molina, A. J. A., Wikström, J. D., Deutsch, M., & Shirihai, O. S. (2007) · Novartis Foundation symposium · doi:10.1002/9780470725207.ch3 · Cited by 6

Mitochondria

(2007) · Methods in molecular biology · doi:10.1007/978-1-59745-365-3 · Cited by 6

ER Tubules Mark Sites of Mitochondrial Division

Friedman, J. R., Lackner, L. L., West, M., DiBenedetto, J. R., Nunnari, J., & Voeltz, G. K. (2011) · Science · doi:10.1126/science.1207385 · Cited by 2,072

Mitochondrial Dynamics and Its Involvement in Disease

Chan, D. C. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032711 · Cited by 1,416

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

Chen, H., & Chan, D. C. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp326 · Cited by 1,506

Mitochondrial dynamics: overview of molecular mechanisms

Tilokani, L., Nagashima, S., Paupe, V., & Prudent, J. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170104 · Cited by 1,397

Mitochondrial dynamics and apoptosis

Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270

Molecular mechanism of mitochondrial membrane fusion

Griffin, E. E., Detmer, S. A., & Chan, D. C. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.02.003 · Cited by 73

OPA1 requires mitofusin 1 to promote mitochondrial fusion

Cipolat, S., de Brito, O. M., Dal Zilio, B., & Scorrano, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407043101 · Cited by 1,300

Review Molecular mechanism of mitochondrial membrane fusion

Griffin, E. E., Detmer, S. A., & Chan, D. C. (2006)

New insights into mitochondrial fusion

Zhang, Y., & Chan, D. C. (2007) · FEBS Letters · doi:10.1016/j.febslet.2007.01.095 · Cited by 59

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

Mishra, P., Carelli, V., Manfredi, G., & Chan, D. C. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.03.011 · Cited by 473