Cited by 413Neuroscience and Neuropharmacology ResearchCellular Mechanics and InteractionsGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

Open access

Korobova, Farida, Svitkina, Tatyana·2010·Molecular Biology of the Cell

DOI 10.1091/mbc.e09-07-0596PMC PMC2801710

Open this paper in CoChat — free account

Abstract

Excitatory synapses in the brain play key roles in learning and memory. The formation and functions of postsynaptic mushroom-shaped structures, dendritic spines, and possibly of presynaptic terminals, rely on actin cytoskeleton remodeling. However, the cytoskeletal architecture of synapses remains unknown hindering the understanding of synapse morphogenesis. Using platinum replica electron microscopy, we characterized the cytoskeletal organization and molecular composition of dendritic spines, their precursors, dendritic filopodia, and presynaptic boutons. A branched actin filament network containing Arp2/3 complex and capping protein was a dominant feature of spine heads and presynaptic boutons. Surprisingly, the spine necks and bases, as well as dendritic filopodia, also contained a network, rather than a bundle, of branched and linear actin filaments that was immunopositive for Arp2/3 complex, capping protein, and myosin II, but not fascin. Thus, a tight actin filament bundle is not necessary for structural support of elongated filopodia-like protrusions. Dynamically, dendritic filopodia emerged from densities in the dendritic shaft, which by electron microscopy contained branched actin network associated with dendritic microtubules. We propose that dendritic spine morphogenesis begins from an actin patch elongating into a dendritic filopodium, which tip subsequently expands via Arp2/3 complex-dependent nucleation and which length is modulated by myosin II-dependent contractility.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1091/mbc.e09-07-0596

Cites

51 of 51 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cellular Motility Driven by Assembly and Disassembly of Actin Filaments
Pollard, T. D., & Borisy, G. G. (2003) · Cell · doi:10.1016/s0092-8674(03)00120-x · Cited by 4,334
Filopodia: molecular architecture and cellular functions
Mattila, P. K., & Lappalainen, P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2406 · Cited by 1,699
Arp2/3 Complex and Actin Depolymerizing Factor/Cofilin in Dendritic Organization and Treadmilling of Actin Filament Array in Lamellipodia
Svitkina, T., & Borisy, G. G. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.5.1009 · Cited by 1,191
Self-citation
The ARP2/3 complex: an actin nucleator comes of age
Goley, E. D., & Welch, M. D. (2006) · Nature reviews. Molecular cell biology · doi:10.1038/nrm2026 · Cited by 1,106
The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003
The lamellipodium: where motility begins
Small, J. V., Stradal, T. E. B., Vignal, E., & Rottner, K. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02237-1 · Cited by 924
Balancing Structure and Function at Hippocampal Dendritic Spines
Bourne, J. N., & Harris, K. M. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125646 · Cited by 916
Actin in action: the interplay between the actin cytoskeleton and synaptic efficacy.
Cingolani, L. A., & Goda, Y. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2373 · Cited by 831
The many faces of actin: matching assembly factors with cellular structures
Chhabra, E. S., & Higgs, H. N. (2007) · Nature Cell Biology · doi:10.1038/ncb1007-1110 · Cited by 779
Mechanism of filopodia initiation by reorganization of a dendritic network
Svitkina, T., Bulanova, E. A., Chaga, O. Y., Vignjevic, D. M., Kojima, S.-I., Vasiliev, J. M., & Borisy, G. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210174 · Cited by 769
Self-citation

Show all 51 references

Research works printed but not linked: 1

Yang C., 2009, PLoS One, 4

Sorted by citations

Items 201–300 of 413

Mechanical transmission at spine synapses: Short-term potentiation and working memory
Kasai, H., Ucar, H., Morimoto, Y., Eto, F., & Okazaki, H. (2023) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2023.102706 · Cited by 23
Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity
Lei, W., Myers, K. R., Rui, Y., Hladyshau, S., Tsygankov, D., & Zheng, J. Q. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201612042 · Cited by 26
The Density and Length of Filopodia Associate with the Activity of Hyaluronan Synthesis in Tumor Cells
Kyykallio, H., Oikari, S., Álvez, M. B., Gallardo-Dodd, C. J., Capra, J., & Rilla, K. J. (2020) · Cancers · doi:10.3390/cancers12071908 · Cited by 24
The role of molecular diffusion within dendritic spines in synaptic function
Obashi, K., Taraska, J. W., & Okabe, S. (2021) · The Journal of General Physiology · doi:10.1085/jgp.202012814 · Cited by 24
Primary Cilia and Dendritic Spines: Different but Similar Signaling Compartments
Nechipurenko, I. V., Doroquez, D. B., & Sengupta, P. (2013) · Molecules and Cells · doi:10.1007/s10059-013-0246-z · Cited by 23
Logical Gates Implemented by Solitons at the Junctions Between One-Dimensional Lattices
Siccardi, S., & Adamatzky, A. (2016) · International Journal of Bifurcation and Chaos · doi:10.1142/s0218127416501078 · Cited by 23
Membrane skeleton modulates erythroid proteome remodeling and organelle clearance
Liu, Y., Mei, Y., Han, X., Korobova, F. V., Prado, M. A., Yang, J. C., Peng, Z., Paulo, J. A., Gygi, S. P., Finley, D. J., et al. (2020) · Blood · doi:10.1182/blood.2020006673 · Cited by 24
Self-citation
A novel role for WAVE1 in controlling actin network growth rate and architecture
Sweeney, M. O., Collins, A., Padrick, S. B., & Goode, B. L. (2014) · Molecular Biology of the Cell · doi:10.1091/mbc.e14-10-1477 · Cited by 24
Molecular Dynamics of the Excitatory Synapse
Okabe, S. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_6 · Cited by 22
SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease
Trujillo‐Estrada, L., Vanderklish, P. W., Nguyen, M. M. T., Kuang, R. R., Nguyen, C., Huynh, E., da Cunha, C., Javonillo, D. I., Forner, S., Martini, A. C., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01143-1 · Cited by 22
Ultrastructural abnormalities in CA1 hippocampus caused by deletion of the actin regulator WAVE-1
Hazai, D., Szudoczki, R., Ding, J., Soderling, S. H., Weinberg, R. J., Sótonyi, P., & Rácz, B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075248 · Cited by 22
Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase
Locke, C., Machida, K., Wu, Y., & Yu, J. H. (2017) · Biology Open · doi:10.1242/bio.029900 · Cited by 22
Neural Activity Selects Myosin IIB and VI with a Specific Time Window in Distinct Dynamin Isoform-Mediated Synaptic Vesicle Reuse Pathways
Hayashida, M., Tanifuji, S., Ma, H., Murakami, N., & Mochida, S. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5028-14.2015 · Cited by 25
The role of the actin cytoskeleton in regulating Drosophila behavior
Ojelade, S. A., Acevedo, S. F., & Rothenfluh, A. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0017 · Cited by 22
Secretagogue Stimulation of Neurosecretory Cells Elicits Filopodial Extensions Uncovering New Functional Release Sites
Papadopulos, A., Martin, S., Tomatis, V. M., Gormal, R. S., & Meunier, F. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2634-13.2013 · Cited by 22
The temporal and spatial changes of actin cytoskeleton in the hippocampal CA1 neurons following transient global ischemia
Guo, C., Xiong, T., Tan, B., Gui, Y., Ye, N., Li, S.-L., & Li, Y. (2019) · Brain Research · doi:10.1016/j.brainres.2019.06.016 · Cited by 21
A two-step actin polymerization mechanism drives dendrite branching
Shi, R., Kramer, D. A., Chen, B., & Shen, K. (2021) · Neural Development · doi:10.1186/s13064-021-00154-0 · Cited by 19
ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons
Hlushchenko, I., Khanal, P., Abouelezz, A., Paavilainen, V. O., & Hotulainen, P. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00217 · Cited by 22
PLPP/CIN regulates bidirectional synaptic plasticity via GluN2A interaction with postsynaptic proteins
Kim, J., Kim, Y.-J., Lee, D.-S., Kim, J. Y., Ko, A.-R., Hyun, H.-W., Kim, M. J., & Kang, T. (2016) · Scientific Reports · doi:10.1038/srep26576 · Cited by 21
Calsyntenin-1 Negatively Regulates ICAM5 Accumulation in Postsynaptic Membrane and Influences Dendritic Spine Maturation in a Mouse Model of Fragile X Syndrome
Cheng, K., Chen, Y.-S., Yue, C., Zhang, S., Pei, Y.-P., Cheng, G.-R., Liu, D., Xu, L., Dong, H.-X., & Zeng, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01098 · Cited by 19
Regulation of Spine Density and Morphology by IQGAP1 Protein Domains
Jausoro, I., Mestres, I., Quassollo, G., Masseroni, L., Heredia, F., & Cáceres, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056574 · Cited by 19
Comparing Transcriptome Profiles of Neurons Interfacing Adjacent Cells and Nanopatterned Substrates Reveals Fundamental Neuronal Interactions
Baranes, K., Hibsh, D., Cohen, S., Yamin, T., Efroni, S., Sharoni, A., & Shefi, O. (2019) · Nano Letters · doi:10.1021/acs.nanolett.8b03879 · Cited by 18
Mice null for NEDD9 (HEF1) display extensive hippocampal dendritic spine loss and cognitive impairment
Knutson, D. C., Mitzey, A. M., Talton, L. E., & Clagett‐Dame, M. (2015) · Brain Research · doi:10.1016/j.brainres.2015.12.005 · Cited by 18
Deletion of KIBRA, protein expressed in kidney and brain, increases filopodial-like long dendritic spines in neocortical and hippocampal neurons in vivo and in vitro
Blanqué, A., Repetto, D., Rohlmann, A., Brockhaus, J., Duning, K., Pavenstädt, H. J., Wolff, I., & Missler, M. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00013 · Cited by 18
Myosin XVI Regulates Actin Cytoskeleton Dynamics in Dendritic Spines of Purkinje Cells and Affects Presynaptic Organization
Roesler, M. K., Lombino, F. L., Freitag, S., Schweizer, M., Hermans‐Borgmeyer, I., Schwarz, J. R., Kneussel, M., & Wagner, W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00330 · Cited by 18
Interrogating Synaptic Architecture: Approaches for Labeling Organelles and Cytoskeleton Components
Reshetniak, S., & Rizzoli, S. O. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00023 · Cited by 17
Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines
Kastian, R. F., Minegishi, T., Baba, K., Saneyoshi, T., Katsuno‐Kambe, H., Saranpal, S., Hayashi, Y., & Inagaki, N. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109130 · Cited by 17
Correction: Optogenetic activation of EphB2 receptor in dendrites induced actin polymerization by activating Arg kinase
Locke, C., Machida, K., Tucker, C. L., Wu, Y., & Yu, J. H. (2018) · Biology Open · doi:10.1242/bio.034694 · Cited by 17
Sleep promotes the formation of dendritic filopodia and spines near learning-inactive existing spines
Adler, A., Lai, C. S. W., Yang, G., Geron, E., Bai, Y., & Gan, W. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2114856118 · Cited by 17
Actomyosin Contractility in the Generation and Plasticity of Axons and Dendritic Spines
Mikhaylova, M., Rentsch, J., & Ewers, H. (2020) · Cells · doi:10.3390/cells9092006 · Cited by 17
Inositol-1,4,5-trisphosphate-3-kinase-A controls morphology of hippocampal dendritic spines
Köster, J.-D., Leggewie, B., Blechner, C., Brandt, N., Fester, L., Rune, G. M., Schweizer, M., Kindler, S., & Windhorst, S. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.10.016 · Cited by 16
Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation
Yagi, H., Nagano, T., Xie, M.-J., Ikeda, H., Kuroda, K., Komada, M., Iguchi, T., Tariqur, R. M., Morikubo, S., Noguchi, K., et al. (2014) · Scientific Reports · doi:10.1038/srep06353 · Cited by 17
Actin capping protein regulates postsynaptic spine development through CPI-motif interactions
Myers, K. R., Fan, Y., McConnell, P., Cooper, J. A., & Zheng, J. Q. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1020949 · Cited by 14
EVL and MIM/MTSS1 regulate actin cytoskeletal remodeling to promote dendritic filopodia in neurons
Parker, S. S., Ly, K. T., Grant, A. D., Sweetland, J. A., Wang, A. M., Parker, J. D., Roman, M. R., Saboda, K., Roe, D. J., Padi, M., et al. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202106081 · Cited by 15
Dendritic spine morphology and dynamics in health and disease
Webb, D. J., Lee, S. N., & Zhang, H. (2015) · Cell Health and Cytoskeleton · doi:10.2147/chc.s82214 · Cited by 17
Input‐specific regulation of hippocampal circuit maturation by non‐muscle myosin IIB
Ozkan, E. D., Aceti, M., Creson, T. K., Rojas, C., Hubbs, C., McGuire, M. N., Kakad, P. P., Miller, C. A., & Rumbaugh, G. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13146 · Cited by 15
A minimal actomyosin-based model predicts the dynamics of filopodia on neuronal dendrites
Marchenko, O. O., Das, S., Yu, J. H., Novak, I. L., Rodionov, V., Efimova, N., Svitkina, T., Wolgemuth, C. W., & Loew, L. M. (2017) · Molecular Biology of the Cell · doi:10.1091/mbc.e16-06-0461 · Cited by 15
Self-citation
Sculpting the dendritic landscape: Actin, microtubules, and the art of arborization
Ouzounidis, V. R., Prevo, B., & Cheerambathur, D. K. (2023) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2023.102214 · Cited by 14
In Vivo Study of Dynamics and Stability of Dendritic Spines on Olfactory Bulb Interneurons in Xenopus laevis Tadpoles
Huang, Y., Hu, C., Zhang, L., Wu, Y., & Hu, B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140752 · Cited by 16
Olfactory bulb proteins linked to olfactory memory in C57BL/6J mice
Li, L., Mauric, V., Zheng, J.-F., Kang, S. U., Patil, S. S., Höger, H., & Lübec, G. (2010) · Amino Acids · doi:10.1007/s00726-010-0543-1 · Cited by 14
Palmitoylated Proteins in Dendritic Spine Remodeling
Albanesi, J. P., Baryłko, B., Demartino, G., & Jameson, D. M. (2020) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2020.00022 · Cited by 13
The Protective Effect of Docosahexaenoic Acid on PC12 Cells in Oxidative Stress Induced by H2O2 through the TrkB-Erk1/2-CREB Pathway
Bie, N., Feng, X., Li, C., Meng, M., & Wang, C. (2021) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.1c00421 · Cited by 13
Age-dependent increase of cytoskeletal components in sensory axons in human skin
Metzner, K., Darawsha, O., Wang, M., Gaur, N., Cheng, Y., Rödiger, A., Frahm, C., Witte, O. W., Perocchi, F., Axer, H., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.965382 · Cited by 12
Biophysical Modeling of Synaptic Plasticity
Lee, C. T., Bell, M. K., Bonilla-Quintana, M., & Rangamani, P. (2024) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-072123-124954 · Cited by 16
L-type Ca 2+ channel activation of STIM1–Orai1 signaling remodels the dendritic spine ER to maintain long-term structural plasticity
Dittmer, P. J., & Dell’Acqua, M. L. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2407324121 · Cited by 12
Cytoskeletal regulation of synaptogenesis in a model of human fetal brain development
Wilson, E. S., Rudisill, T., Kirk, B., Johnson, C., Kemper, P., & Litwa, K. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24692 · Cited by 12
A Uniform and Isotropic Cytoskeletal Tiling Fills Dendritic Spines
Eberhardt, F., Bushong, E. A., Phan, S., Peltier, S. T., Monteagudo-Mesas, P., Weinkauf, T., Herz, A. V. M., Stemmler, M., & Ellisman, M. H. (2022) · eNeuro · doi:10.1523/eneuro.0342-22.2022 · Cited by 12
More than one ring to bind them all: Recent insights into the structure of the axon
Gallo, G. (2013) · Developmental Neurobiology · doi:10.1002/dneu.22100 · Cited by 12
Quantitative proteomic analysis of HIV‐1 Tat‐induced dysregulation in SH‐SY5Y neuroblastoma cells
Ganief, T. A., Gqamana, P. P., Garnett, S., Hoare, J., Stein, D. J., Joska, J. A., Soares, N. C., & Blackburn, J. M. (2017) · PROTEOMICS · doi:10.1002/pmic.201600236 · Cited by 12
Translation elongation factor-1A1 (eEF1A1) localizes to the spine by domain III
Cho, S., Lee, H., Dutta, S., Seog, D., & Moon, I.-S. (2012) · BMB Reports · doi:10.5483/bmbrep.2012.45.4.227 · Cited by 12
Participación de las proteínas de unión a la actina y vías de señalización asociadas a la formación y mantenimiento de las espinas dendríticas
Soria-Fregozo, C., & Vega, M. I. P. (2011) · Neurología · doi:10.1016/j.nrl.2011.10.005 · Cited by 13
A biscoumarinyl hydrazone based nontoxic fluorescent dye for direct binding and imaging of actin in living cells and organism
Murmu, N., Dash, K., Panda, J., Sahoo, G., Sahoo, H., Mishra, M., & Sahu, S. N. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.134741 · Cited by 11
Short Lives with Long-Lasting Effects: Filopodia Protrusions in Neuronal Branching Morphogenesis
Leondaritis, G., & Eickholt, B. J. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002241 · Cited by 11
Role of actin cytoskeleton in the organization and function of ionotropic glutamate receptors
Dutta, P., Bharti, P., Kumar, J., & Maiti, S. (2021) · Current Research in Structural Biology · doi:10.1016/j.crstbi.2021.10.001 · Cited by 11
nArgBP2-SAPAP-SHANK, the core postsynaptic triad associated with psychiatric disorders
Lee, S., Kim, J. A., & Chang, S. (2018) · Experimental & Molecular Medicine · doi:10.1038/s12276-017-0018-5 · Cited by 13
Methodological approaches to understand the molecular mechanism of structural plasticity of dendritic spines
Mikuni, T., & Uchigashima, M. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14734 · Cited by 11
The E3 ubiquitin ligase TRIM9 regulates synaptic function and actin dynamics in response to netrin-1
McCormick, L. E., Evans, E. B., Barker, N. K., Herring, L. E., Diering, G. H., & Gupton, S. L. (2024) · Molecular Biology of the Cell · doi:10.1091/mbc.e23-12-0476 · Cited by 10
Actin-binding proteins and signalling pathways associated with the formation and maintenance of dendritic spines
Soria-Fregozo, C., & Vega, M. I. P. (2012) · Neurología (English Edition) · doi:10.1016/j.nrleng.2011.10.006 · Cited by 11
Different changes in pre- and postsynaptic components in the hippocampal CA1 subfield after transient global cerebral ischemia
Zhang, Y., Tan, B., Wu, S., Wu, C., Suo, J., Gui, Y., Zhou, C.-M., & Li, Y. (2021) · Brain Structure and Function · doi:10.1007/s00429-021-02404-7 · Cited by 10
Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre‐synaptic membrane protein, syntaxin‐1, in hippocampal neurons
MacDonald, J. I., Dietrich, A., Gamble, S. J., Hryciw, T., Grant, R. I., & Meakin, S. O. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07729.x · Cited by 10
Src-mediated phosphorylation of βPix-b regulates dendritic spine morphogenesis
Shin, M.-S., Song, S., Shin, J. E., Lee, S.-H., Huh, S., & Park, D. (2019) · Journal of Cell Science · doi:10.1242/jcs.224980 · Cited by 10
Growth hormone increases dendritic spine density in primary hippocampal cell cultures
Nylander, E., Zelleroth, S., Stam, F., Nyberg, F., Grönbladh, A., & Hallberg, M. (2019) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2019.12.003 · Cited by 11
TIMP-1 enhances Akt and BDNF signaling in neurons to reduce synaptic and cognitive deficits in 5xFAD mouse model of Alzheimer’s disease
Sarkar, S., Gharami, K., Mondal, A., Padmanabhan, K., Paidi, R. K., Srikumar, B. N., & Biswas, S. C. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02060-6 · Cited by 9
FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortex
Falace, A., Corbières, L., Palminha, C., Guarnieri, F. C., Schaller, F., Buhler, E., Carlo, C. T. D. S., Montheil, A., Watrin, F., Manent, J., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106558 · Cited by 9
Matrix Metalloproteinase-9 Overexpression Regulates Hippocampal Synaptic Plasticity and Decreases Alcohol Consumption and Preference in Mice
Yin, L.-T., Xie, X., Xue, L., Yang, X. R., Jia, J., Zhang, Y., & Zhang, C. (2020) · Neurochemical Research · doi:10.1007/s11064-020-03053-8 · Cited by 9
Myosin 18Aα targets the guanine nucleotide exchange factor β‐Pix to the dendritic spines of cerebellar Purkinje neurons and promotes spine maturation
Alexander, C. J., Barzik, M., Fujiwara, I., Remmert, K., Wang, Y., Petralia, R. S., Friedman, T. B., & Hammer, J. A. (2020) · The FASEB Journal · doi:10.1096/fj.202001449r · Cited by 9
Finger-like membrane protrusions are favored by heterogeneities in the actin network
Gat, S., Simon, C., Campillo, C. C., Bernheim‐Groswasser, A., & Sykes, C. (2020) · Soft Matter · doi:10.1039/c9sm02444a · Cited by 8
Imaging of spine synapses using super-resolution microscopy
Kashiwagi, Y., & Okabe, S. (2021) · Anatomical Science International · doi:10.1007/s12565-021-00603-0 · Cited by 9
Drosophila Dendritic Arborisation Neurons: Fantastic Actin Dynamics and Where to Find Them
Kilo, L., Stürner, T., Tavosanis, G., & Ziegler, A. B. (2021) · Cells · doi:10.3390/cells10102777 · Cited by 8
Precursor types predict the stability of neuronal branches
Fuchs, J., & Eickholt, B. J. (2021) · Journal of Cell Science · doi:10.1242/jcs.258983 · Cited by 8
The rearrangement of filamentous actin in mossy fiber synapses in pentylenetetrazol-kindled C57BL/6 mice
Zhang, Y.-F., Li, S.-L., Xiong, T., Yang, L., Li, Y., Tan, B., li, Y.-C., & li, Y.-C. (2013) · Epilepsy Research · doi:10.1016/j.eplepsyres.2013.10.019 · Cited by 8
Hippocampal Dendritic Spines Are Segregated Depending on Their Actin Polymerization
Domıńguez-Iturza, N., Calvo, M., Benoist, M., Esteban, J. A., & Morales, M. (2016) · Neural Plasticity · doi:10.1155/2016/2819107 · Cited by 8
Relationship Between Learning and Memory Deficits and Arp2 Expression in the Hippocampus in Rats with Traumatic Brain Injury
Xia, X., Dong, Y., Yiqing, D., Yang, Y., Wang, W., & Li, Y. (2011) · World Neurosurgery · doi:10.1016/j.wneu.2011.07.042 · Cited by 8
Can biophysical models of dendritic spines be used to explore synaptic changes associated with addiction?
Bonilla-Quintana, M., & Rangamani, P. (2022) · Physical Biology · doi:10.1088/1478-3975/ac6cbe · Cited by 7
Dendritic effects of genetically encoded actin-labeling probes in cultured hippocampal neurons
Ignácz, A., Nagy-Herczeg, D., Haußer, A., & Schlett, K. (2023) · Molecular Biology of the Cell · doi:10.1091/mbc.e22-08-0331 · Cited by 8
Matrix metalloproteinase-9 overexpression in the hippocampus reduces alcohol-induced conditioned-place preference by regulating synaptic plasticity in mice
Yin, L., Feng, R.-R., Xie, X., Yang, X., Yang, Z.-F., Hu, J., Wu, S.-F., & Zhang, C. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114330 · Cited by 7
Study of laser uncaging induced morphological alteration of rat cortical neurites using atomic force microscopy
Tian, J. H., Tu, C., Liang, Y., Zhou, J., & Ye, X. (2015) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2015.06.018 · Cited by 7
Polarity Determinants in Dendritic Spine Development and Plasticity
Zhang, H. (2015) · Neural Plasticity · doi:10.1155/2016/3145019 · Cited by 8
The initiation of post-synaptic protrusions
Hotulainen, P., & Saarikangas, J. (2016) · Communicative & Integrative Biology · doi:10.1080/19420889.2015.1125053 · Cited by 10
BDNF-dependent nano-organization of Neogenin and the WAVE regulatory complex promotes actin remodeling in dendritic spines
Shohayeb, B., Sempert, K., Wallis, T. P., Meunier, F. A., Durisic, N., O’Brien, E. A., Flores, C., & Cooper, H. M. (2024) · iScience · doi:10.1016/j.isci.2024.110621 · Cited by 6
F-dynamics: Automated quantification of dendrite filopodia dynamics in living neurons
Hendricusdottir, R., & Bergmann, J. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.08.016 · Cited by 6
Neuro at the Nanoscale
Castro, J. B., & Gould, T. J. (2015) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155415610169 · Cited by 6
Different patterns of changes between actin dynamics and synaptic density in the rat’s primary visual cortex during a special period of visual development
Chen, M.-Q., Bi, A.-L., Zhang, Y., Yan, Q., Sun, Y., Zhang, X., Ma, X., & Bi, H. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.06.004 · Cited by 6
RGMa and Neogenin control dendritic spine morphogenesis via WAVE Regulatory Complex-mediated actin remodeling
Sempert, K., Shohayeb, B., Lanoue, V., O’Brien, E. A., Flores, C., & Cooper, H. M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1253801 · Cited by 6
Neuron as a reward-modulated combinatorial switch and a model of learning behavior
Rvachev, M. (2013) · Neural Networks · doi:10.1016/j.neunet.2013.04.010 · Cited by 8
Automated Analysis of Neuronal Morphology through an Unsupervised Classification Model of NeuritesPreprint
Zehtabian, A., Fuchs, J., Eickholt, B. J., & Ewers, H. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.01.482454 · Cited by 6
Super-resolution imaging reveals the relationship between CaMKIIβ and drebrin within dendritic spines.
Yamazaki, H., Koganezawa, N., Yokoo, H., Sekino, Y., & Shirao, T. (2023) · Neurosciences research · doi:10.1016/j.neures.2023.08.002 · Cited by 5
Deciphering the role of CAPZA2 in neurodevelopmental disorders: insights from mouse models
Guo, M., Liu, L., Mao, X. O., Xiao, M., He, X., Pan, X., Chen, Y., Yi, W., Li, Q., Piao, X., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-08385-1 · Cited by 5
Actin Cytoskeleton Polymerization and Focal Adhesion as Important Factors in the Pathomechanism and Potential Targets of Mucopolysaccharidosis Treatment
Gaffke, L., Rintz, E., Pierzynowska, K., & Węgrzyn, G. (2023) · Cells · doi:10.3390/cells12131782 · Cited by 5
Broadening the spectrum of actin‐based protrusive activity mediated by Arp2/3 complex‐facilitated polymerization: Motility of cytoplasmic ridges and tubular projections
Henson, J. H., Gianakas, A. D., Henson, L. H., Lakin, C. L., Voss, M. K., Bewersdorf, J., Oldenbourg, R., & Morris, R. L. (2014) · Cytoskeleton · doi:10.1002/cm.21186 · Cited by 5
The Neuronal Actin Cytoskeleton and the Protrusion of Lamellipodia and Filopodia
Gallo, G. (2010) · Advances in neurobiology · doi:10.1007/978-1-4419-7368-9_2 · Cited by 5
Differential expression of CARMIL‐family genes during zebrafish development
Stark, B. C., & Cooper, J. A. (2015) · Cytoskeleton · doi:10.1002/cm.21257 · Cited by 5
Small, smaller… dendritic spine
Boyl, P. P., & Witke, W. (2014) · The EMBO Journal · doi:10.15252/embj.201490137 · Cited by 5
KCC2 regulates dendritic spine development
Llano, O., Rivera, C., & Ludwig, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-815318-5.00006-6 · Cited by 5
Comparative proteomics analysis of normal and memory-deficient Drosophila melanogaster heads
Lee, T., Lee, H., Huang, S., Chan, H., Lyu, P. C., & Chan, H. (2013) · Zoological studies · doi:10.1186/1810-522x-52-10 · Cited by 5
Distinct nano-structures support a multifunctional role of actin at presynapses
Bingham, D., Wernert, F., Costa Moura, J. D., Boroni-Rueda, F., van Bommel, N., Caillol, G., Papandréou, M.-J., & Leterrier, C. (2022) · doi:10.1101/2022.05.18.492480 · Cited by 5
Synaptic Plasticity in the Hippocampus
Bliss, T., Collingridge, G. L., Cooke, S. F., Georgiou, J., & Morris, R. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0010 · Cited by 4
Neuronal Actin Remodeling and Its Role in Higher Nervous Activity
Zhuravlev, A. V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262211215 · Cited by 5
Voluntary exercise during puberty promotes spatial memory and hippocampal DG/CA3 synaptic transmission in mice
Wan, C., Song, X., Zhang, Z., Hu, W., Chen, Y., Sun, W., Liu, Z., Wang, S., & Meng, W. (2023) · Cerebral Cortex · doi:10.1093/cercor/bhad497 · Cited by 5
Cytoskeletal Organization: Actin
Abouelezz, A. M., Minkeviciene, R., & Hotulainen, P. (2016) · Springer eBooks · doi:10.1007/978-4-431-56050-0_2 · Cited by 4

Authors: Korobova, F., & Svitkina, T.
Affiliations: University of Pennsylvania (US)
Corresponding author: Svitkina, Tatyana
ORCID: Korobova, Farida
Svitkina, Tatyana
Venue: Molecular Biology of the Cell
Publisher: American Society for Cell Biology (ASCB)
Published: 2010-01
Volume: 21
Issue: 1
Pages: 165-176
ISSN: 1059-1524 (ISSN-L)
1939-4586
DOI: 10.1091/mbc.e09-07-0596
PMC: PMC2801710
OpenAlex: W2031516445
Cited by: 399
References: 51
Citations by year: 2026: 7 · 2025: 13 · 2024: 19 · 2023: 22 · 2022: 21 · 2021: 25 · 2020: 28 · 2019: 23 · 2018: 30 · 2017: 24 · 2016: 30 · 2015: 27 · 2014: 36 · 2013: 34 · 2012: 27
FWCI: 10.09
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Molecular Biology of the Cell (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of General Medical Sciences (R01GM070898, GM 70898)
National Center for Research Resources (RR-22482, S10RR022482)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: dendritic spine morphogenesis, hippocampal neurons, Arp2/3 complex, capping protein, myosin II, dendritic filopodia, presynaptic terminals, actin filament nucleation, microtubules, excitatory synapses
MeSH terms: Actins, Cytoskeletal Proteins, Cytoskeleton, Fluorescent Antibody Technique, Hippocampus, Models, Biological, Pseudopodia, Synapses, Biomarkers, Cell Shape, Dendritic Spines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Molecular Architecture of Synaptic Actin Cytoskeleton in Hippocampal Neurons Reveals a Mechanism of Dendritic Spine Morphogenesis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks