Differential localization and dynamics of class I myosins in the enterocyte microvillus
Open accessAbstract
Epithelial cells lining the intestinal tract build an apical array of microvilli known as the brush border. Each microvillus is a cylindrical membrane protrusion that is linked to a supporting actin bundle by myosin-1a (Myo1a). Mice lacking Myo1a demonstrate no overt physiological symptoms, suggesting that other myosins may compensate for the loss of Myo1a in these animals. To investigate changes in the microvillar myosin population that may limit the Myo1a KO phenotype, we performed proteomic analysis on WT and Myo1a KO brush borders. These studies revealed that WT brush borders also contain the short-tailed class I myosin, myosin-1d (Myo1d). Myo1d localizes to the terminal web and striking puncta at the tips of microvilli. In the absence of Myo1a, Myo1d peptide counts increase twofold; this motor also redistributes along the length of microvilli, into compartments normally occupied by Myo1a. FRAP studies demonstrate that Myo1a is less dynamic than Myo1d, providing a mechanistic explanation for the observed differential localization. These data suggest that Myo1d may be the primary compensating class I myosin in the Myo1a KO model; they also suggest that dynamics govern the localization and function of different yet closely related myosins that target common actin structures.
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The increase in myosin-1 could indicate increased epithelial cell turnover in the small intestine in the high-fermented food cohort.
“Its increase could indicate increased epithelial cell turnover within the small intestine in the high-fermented food diet cohort (Benesh et al., 2010).”
From Gut-microbiota-targeted diets modulate human immune status (2021) · cites this paper as Benesh et al., 2010
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Myosin-1b interacts with UNC45A and controls intestinal epithelial morphogenesisPreprint
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- Authors
- Benesh, A. E., Nambiar, R., McConnell, R. E., Mao, S., Tabb, D. L., & Tyska, M. J.
- Affiliations
- Vanderbilt University (US)
- *Cell and Developmental Biology Department, and
- Corresponding author
- Tyska, Matthew J.
- Venue
- Molecular Biology of the Cell
- Published
- 2010-03-15
- Volume
- 21
- Issue
- 6
- Pages
- 970-978
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- PMC
- PMC2836977
- OpenAlex
- W2127598975
- Cited by
- 50
- References
- 31
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 1 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 10
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Biology of the Cell (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association (09GRNT2310188)
- Vanderbilt University Medical Center
- National Institutes of Health (5r01ca126218-05, P30 DK)
- National Cancer Institute (R01-CA-126218)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK075555, P30DK058404)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007502)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- class I myosin, brush border, terminal web, myosin localization, intestinal epithelium
- MeSH terms
- Animals, Cell Line, Microvilli, Myosins, Recombinant Fusion Proteins, Mice, Knockout, Myosin Heavy Chains, Protein Isoforms, Enterocytes, Fluorescence Recovery After Photobleaching, Proteomics, Mice, Rats
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