The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
HSP90 Protein Stabilizes Unloaded Argonaute Complexes and Microscopic P-bodies in Human Cells
Open accessAbstract
Key components of the miRNA-mediated gene regulation pathway are localized in cytoplasmic processing bodies (P-bodies). Mounting evidence suggests that the presence of microscopic P-bodies are not always required for miRNA-mediated gene regulation. Here we have shown that geldanamycin, a well-characterized HSP90 inhibitor, abolishes P-bodies and significantly reduces Argonaute and GW182 protein levels but does not affect the miRNA level and the efficiency of miRNA-mediated gene repression; however, it significantly impairs siRNA loading and the efficacy of exogenous siRNA. Our data suggests that HSP90 protein chaperones Argonautes before binding RNA and may facilitate efficient loading of small RNA.
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Cites
P-body formation is a consequence, not the cause, of RNA-mediated gene silencing
Eulalio, A., Behm-Ansmant, I., Schweizer, D., & Izaurralde, E. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00128-07 · Cited by 710
Sequence-specific inhibition of small RNA function
Hutvágner, G., Simard, M. J., Mello, C. C., & Zamore, P. D. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020098 · Cited by 584
Self-citation
Cited by
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
The widespread regulation of microRNA biogenesis, function and decay
Krol, J., Loedige, I., & Filipowicz, W. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2843 · Cited by 4,672
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
Taipale, M., Jarosz, D. F., & Lindquist, S. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2918 · Cited by 1,818
Regulation of microRNA biogenesis and its crosstalk with other cellular pathways
Treiber, T., Treiber, N., & Meister, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0059-1 · Cited by 1,252
MicroRNA functions in stress responses
Leung, A. K. L., & Sharp, P. A. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.027 · Cited by 865
Metadata
- Authors
- Johnston, M., Geoffroy, M.-C., Sobala, A., Hay, R., & Hutvagner, G.
- Venue
- Molecular Biology of the Cell
- Published
- 2010-05
- Volume
- 21
- Issue
- 9
- Pages
- 1462-1469
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2140786935
- Cited by
- 194
- References
- 2
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Johnston, M., Geoffroy, M.-C., Sobala, A., Hay, R., & Hutvagner, G. (2010). HSP90 Protein Stabilizes Unloaded Argonaute Complexes and Microscopic P-bodies in Human Cells. Molecular Biology of the Cell. https://doi.org/10.1091/mbc.e09-10-0885
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