The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
β-Actin specifically controls cell growth, migration, and the G-actin pool
Open accessAbstract
Ubiquitously expressed β-actin and γ-actin isoforms play critical roles in most cellular processes; however, their unique contributions are not well understood. We generated whole-body β-actin–knockout (Actb−/−) mice and demonstrated that β-actin is required for early embryonic development. Lethality of Actb−/−embryos correlated with severe growth impairment and migration defects in β-actin–knockout primary mouse embryonic fibroblasts (MEFs) that were not observed in γ-actin–null MEFs. Migration defects were associated with reduced membrane protrusion dynamics and increased focal adhesions. We also identified migration defects upon conditional ablation of β-actin in highly motile T cells. Of great interest, ablation of β-actin altered the ratio of globular actin (G-actin) to filamentous actin in MEFs, with corresponding changes in expression of genes that regulate the cell cycle and motility. These data support an essential role for β-actin in regulating cell migration and gene expression through control of the cellular G-actin pool.
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Cites
Calcium flickers steer cell migration
Wei, C., Wang, X., Chen, M., Ouyang, K., Song, L.-S., & Cheng, H. (2009) · Nature · doi:10.1038/nature07577 · Cited by 611
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Genetic compensation: A phenomenon in search of mechanisms
El-Brolosy, M. A., & Stainier, D. Y. R. (2017) · PLOS Genetics · doi:10.1371/journal.pgen.1006780 · Cited by 829
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers
Gu, Y., Tang, S., Wang, Z., Cai, L., Lian, H., Shen, Y., & Zhou, Y. (2021) · Bioengineered · doi:10.1080/21655979.2021.1973220 · Cited by 99
Kamnev, A., Lacouture, C., Fusaro, M., & Dupré, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.750537 · Cited by 38
Tikhonova, M. A., Amstislavskaya, T. G., Belichenko, V. M., Fedoseeva, L. A., Kovalenko, S. P., Pisareva, E. E., Avdeeva, A. S., Kolosova, N. G., Belyaev, N. D., & Aftanas, L. I. (2018) · BMC Neuroscience · doi:10.1186/s12868-018-0412-5 · Cited by 30
Hecquet, T., Arbogast, N., Suhner, D., Goetz, A., Amann, G., Yürekli, S., Marangoni, F., Quintin, S., Greve, J. N., Di Donato, N., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113652 · Cited by 4
Metadata
- Authors
- Bunnell, T. M., Burbach, B. J., Shimizu, Y., & Ervasti, J. M.
- Venue
- Molecular Biology of the Cell
- Published
- 2011-11
- Volume
- 22
- Issue
- 21
- Pages
- 4047-4058
- ISSN
- 1059-1524 (ISSN-L)
- 1939-4586
- OpenAlex
- W2123436811
- Cited by
- 320
- References
- 1
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- green
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