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Cited by 38Cellular Mechanics and InteractionsImmunodeficiency and Autoimmune DisordersCell Adhesion Molecules Research

Molecular Tuning of Actin Dynamics in Leukocyte Migration as Revealed by Immune-Related Actinopathies

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Kamnev, Anton, Lacouture, Claire, Fusaro, Mathieu, Dupré, Loïc·2021·Frontiers in Immunology
DOI 10.3389/fimmu.2021.750537PMC PMC8634686
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Abstract

Motility is a crucial activity of immune cells allowing them to patrol tissues as they differentiate, sample or exchange information, and execute their effector functions. Although all immune cells are highly migratory, each subset is endowed with very distinct motility patterns in accordance with functional specification. Furthermore individual immune cell subsets adapt their motility behaviour to the surrounding tissue environment. This review focuses on how the generation and adaptation of diversified motility patterns in immune cells is sustained by actin cytoskeleton dynamics. In particular, we review the knowledge gained through the study of inborn errors of immunity (IEI) related to actin defects. Such pathologies are unique models that help us to uncover the contribution of individual actin regulators to the migration of immune cells in the context of their development and function.

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  • Cells of the innate and adaptive immune systems depend on proper actin dynamics to control effective immune responses.

    “Cells of the innate and adaptive immune systems depend on proper actin dynamics to control effective responses, which is highlighted by inborn errors of immunity (IEI) affecting actin networks, known as actinopathies (reviewed in [3–7]).”

    From HEM1 Actin Immunodysregulatory Disorder: Genotypes, Phenotypes, and Future Directions (2022) · cites this paper as [7]

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  1. [1]Mazo IB Massberg S von Andrian UH. Hematopoietic Stem and Progenitor Cell Trafficking. Trends Immunol (2011) 32: 493– 503. doi: 10.1016/j.it.2011.06.011 21802990 PMC3185129 · DOI
  2. [2]Takahama Y. Journey Through the Thymus: Stromal Guides for T-Cell Development and Selection. Nat Rev Immunol (2006) 6: 127–35. doi: 10.1038/nri1781 16491137 · DOI
  3. [3]Nourshargh S Hordijk PL Sixt M. Breaching Multiple Barriers: Leukocyte Motility Through Venular Walls and the Interstitium. Nat Rev Mol Cell Biol (2010) 11: 366–78. doi: 10.1038/nrm2889 20414258 · DOI
  4. [4]Krummel MF Bartumeus F Gérard A. T Cell Migration, Search Strategies and Mechanisms. Nat Rev Immunol (2016) 16: 193– 201. doi: 10.1038/nri.2015.16 26852928 PMC4869523 · DOI · Paper page
  5. [5]Friedl P Wolf K. Plasticity of Cell Migration: A Multiscale Tuning Model. J Cell Biol (2010) 188: 11–9. doi: 10.1083/jcb.200909003 PMC2812848 19951899 · DOI
  6. [6]Vicente-Manzanares M Sánchez-Madrid F. Role of the Cytoskeleton During Leukocyte Responses. Nat Rev Immunol (2004) 4: 110–22. doi: 10.1038/nri1268 15040584 · DOI
  7. [7]Mastrogiovanni M Juzans M Alcover A Di Bartolo V. Coordinating Cytoskeleton and Molecular Traffic in T Cell Migration, Activation, and Effector Functions. Front Cell Dev Biol (2020) 8: 591348. doi: 10.3389/fcell.2020.591348 33195256 PMC7609836 · DOI
  8. [8]Rottner K Faix J Bogdan S Linder S Kerkhoff E. Actin Assembly Mechanisms at a Glance. J Cell Sci (2017) 3427–35. doi: 10.1242/jcs.206433 29032357 · DOI
  9. [9]Svitkina T. The Actin Cytoskeleton and Actin-Based Motility. Cold Spring Harb Perspect Biol (2018) 10: 1– 21. doi: 10.1101/cshperspect.a018267 PMC5749151 29295889 · DOI · Paper page
  10. [10]Burns SO Zarafov A Thrasher AJ. Primary Immunodeficiencies Due to Abnormalities of the Actin Cytoskeleton. Curr Opin Hematol (2017) 24: 16– 22. doi: 10.1097/MOH.0000000000000296 27749373 · DOI
  11. [11]Janssen E Geha RS. Primary Immunodeficiencies Caused by Mutations in Actin Regulatory Proteins. Immunol Rev (2019) 287: 121–34. doi: 10.1111/imr.12716 30565251 · DOI
  12. [12]Tangye SG Bucciol G Casas-Martin J Pillay B Ma CS Moens L. Human Inborn Errors of the Actin Cytoskeleton Affecting Immunity: Way Beyond WAS and WIP. Immunol Cell Biol (2019) 97: 389– 402. doi: 10.1111/imcb.12243 30779216 · DOI
  13. [13]Papa R Penco F Volpi S Gattorno M. Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation. Front Immunol (2021) 11: 604206. doi: 10.3389/fimmu.2020.604206 33488606 PMC7817698 · DOI · Paper page
  14. [14]Dupré L Boztug K Pfajfer L. Actin Dynamics at the T Cell Synapse as Revealed by Immune-Related Actinopathies. Front Cell Dev Biol (2021) 9: 665519. doi: 10.3389/fcell.2021.665519 34249918 PMC8266300 · DOI · Paper page
  15. [15]Nunoi H Yamazaki T Tsuchiya H Kato S Malech HL Matsuda I. A Heterozygous Mutation of -Actin Associated With Neutrophil Dysfunction and Recurrent Infection. Proc Natl Acad Sci (1999) 96: 8693–8. doi: 10.1073/pnas.96.15.8693 PMC17578 10411937 · DOI
  16. [16]Bunnell TM Burbach BJ Shimizu Y Ervasti JM. β-Actin Specifically Controls Cell Growth, Migration, and the G-Actin Pool. Mol Biol Cell (2011) 22: 4047–58. doi: 10.1091/mbc.E11-06-0582 PMC3204067 21900491 · DOI
  17. [17]Bouafia A Lofek S Bruneau J Chentout L Lamrini H Trinquand A. Loss of ARHGEF1 Causes a Human Primary Antibody Deficiency. J Clin Invest (2019) 129: 1047–60. doi: 10.1172/JCI120572 PMC6391114 30521495 · DOI
  18. [18]Muppidi JR Schmitz R Green JA Xiao W Larsen AB Braun SE. Loss of Signalling via G α 13 in Germinal Centre B-Cell-Derived Lymphoma. Nature (2014) 516: 254–8. doi: 10.1038/nature13765 PMC4267955 25274307 · DOI
  19. [19]Rivers E Rai R Lötscher J Hollinshead M Markelj G Thaventhiran J. Wiskott Aldrich Syndrome Protein Regulates Non-Selective Autophagy and Mitochondrial Homeostasis in Human Myeloid Cells. Elife (2020) 9: 1– 23. doi: 10.7554/eLife.55547 PMC7673780 33135633 · DOI
  20. [20]Brigida I Zoccolillo M Cicalese MP Pfajfer L Barzaghi F Scala S. T-Cell Defects in Patients With ARPC1B Germline Mutations Account for Combined Immunodeficiency. Blood (2018) 132: 2362–74. doi: 10.1182/blood-2018-07-863431 PMC6265646 30254128 · DOI
  21. [21]Randzavola LO Kuijpers TW Gillian M Randzavola LO Strege K Juzans M. Loss of ARPC1B Impairs Cytotoxic T Lymphocyte Maintenance and Cytolytic Activity. J Clin Invest (2019) 129: 1– 15. doi: 10.1172/JCI129388 31710310 PMC6877333 · DOI
  22. [22]Kahr WHA Pluthero FG Elkadri A Warner N Drobac M Chen CH. Loss of the Arp2/3 Complex Component ARPC1B Causes Platelet Abnormalities and Predisposes to Inflammatory Disease. Nat Commun (2017) 8: 1– 14. doi: 10.1038/ncomms14816 28368018 PMC5382316 · DOI
  23. [23]Schober T Magg T Laschinger M Rohlfs M Linhares ND Puchalka J. A Human Immunodeficiency Syndrome Caused by Mutations in CARMIL2. Nat Commun (2017) 8: 1– 13. doi: 10.1038/ncomms14209 28112205 PMC5473639 · DOI
  24. [24]Lam MT Coppola S Krumbach OHF Prencipe G Insalaco A Cifaldi C. A Novel Disorder Involving Dyshematopoiesis, Inflammation, and HLH Due to Aberrant CDC42 Function. J Exp Med0 (2019). p. 2778–99. doi: 10.1084/jem.20190147 PMC6888978 31601675 · DOI
  25. [25]Kumar S Xu J Perkins C Guo F Snapper S Finkelman FD. Cdc42 Regulates Neutrophil Migration via Crosstalk Between WASp, CD11b, and Microtubules. Blood (2012) 120: 3563–74. doi: 10.1182/blood-2012-04-426981 PMC3482864 22932798 · DOI
  26. [26]Szczur K Zheng Y Filippi MD. The Small Rho GTPase Cdc42 Regulates Neutrophil Polarity via CD11b Integrin Signaling. Blood (2009) 114: 4527–37. doi: 10.1182/blood-2008-12-195164 PMC3403354 19752396 · DOI
  27. [27]Shiow L Roadcap D Paris K Watson S Cyster J. The Actin Regulator Coronin-1A Is Mutated in a Thymic Egress Deficient Mouse Strain and in a T–B+ NK+ SCID Patient. Nature (2008) 9: 1307–15. doi: 10.1038/ni.1662.The PMC2672406 18836449 · DOI
  28. [28]Yee CS Massaad MJ Bainter W Ohsumi TK Föger N Chan AC. Recurrent Viral Infections Associated With a Homozygous CORO1A Mutation That Disrupts Oligomerization and Cytoskeletal Association. J Allergy Clin Immunol (2016) 137: 879– 88.e2. doi: 10.1016/j.jaci.2015.08.020 26476480 PMC4783242 · DOI
  29. [29]Yagi H Matsumoto M Nakamura M Makino S Suzuki R Harada M. Defect of Thymocyte Emigration in a T Cell Deficiency Strain (CTS) of the Mouse. J Immunol (1996) 157: 3412–9. 8871639
  30. [30]Foger N Rangell L Danilenko D Chan A. Requirement for Coronin 1 in T Lymphocyte Trafficking and Cellular Homeostasis. Sci (80-) (2006) 313: 839–42. doi: 10.1016/b978-1-4832-3292-8.50018-7 16902139 · DOI
  31. [31]Pick R Begandt D Stocker TJ Salvermoser M Thome S Böttcher RT. Coronin 1A, a Novel Player in Integrin Biology, Controls Neutrophil Trafficking in Innate Immunity. Blood (2017) 130: 847–58. doi: 10.1182/blood-2016-11-749622 28615221 · DOI
  32. [32]Kaustio M Nayebzadeh N Hinttala R Tapiainen T Åström P Mamia K. Loss of DIAPH1 Causes SCBMS, Combined Immunodeficiency, and Mitochondrial Dysfunction. J Allergy Clin Immunol (2021) 148: 599– 611. doi: 10.1016/j.jaci.2020.12.656 33662367 · DOI
  33. [33]Sakata D Taniguchi H Yasuda S Adachi-Morishima A Hamazaki Y Nakayama R. Impaired T Lymphocyte Trafficking in Mice Deficient in an Actin-Nucleating Protein, Mdia1. J Exp Med (2007) 204: 2031–8. doi: 10.1084/jem.20062647 PMC2118705 17682067 · DOI
  34. [34]Dobbs K Domínguez Conde C Zhang S-Y Parolini S Audry M Chou J. Inherited DOCK2 Deficiency in Patients With Early-Onset Invasive Infections. N Engl J Med (2015) 372: 2409–22. doi: 10.1056/nejmoa1413462 PMC4480434 26083206 · DOI · Paper page
  35. [35]Nombela-Arrieta C Mempel TR Soriano SF Mazo I Wymann MP Hirsch E. A Central Role for DOCK2 During Interstitial Lymphocyte Motility and Sphingosine-1-Phosphate-Mediated Egress. J Exp Med (2007) 204: 497– 510. doi: 10.1084/jem.20061780 17325199 PMC2137902 · DOI
  36. [36]Nombela-Arrieta C Lacalle RA Montoya MC Kunisaki Y Megías D Marqués M. Differential Requirements for DOCK2 and Phosphoinositide-3-Kinase γ During T and B Lymphocyte Homing. Immunity (2004) 21: 429–41. doi: 10.1016/j.immuni.2004.07.012 15357953 · DOI
  37. [37]Zhang Q Dove CG Hor JL Murdock HM Strauss-Albee DM Garcia JA. DOCK8 Regulates Lymphocyte Shape Integrity for Skin Antiviral Immunity. J Exp Med (2014) 211: 2549–66. doi: 10.1084/jem.20141307 PMC4267229 25422492 · DOI
  38. [38]Harada Y Tanaka Y Terasawa M Pieczyk M Habiro K Katakai T. DOCK8 Is a Cdc42 Activator Critical for Interstitial Dendritic Cell Migration During Immune Responses. Blood (2012) 119: 4451–61. doi: 10.1182/blood-2012-01-407098 PMC3418773 22461490 · DOI · Paper page
  39. [39]Hirata T Nomachi A Tohya K Miyasaka M Tsukita S Watanabe T. Moesin-Deficient Mice Reveal a Non-Redundant Role for Moesin in Lymphocyte Homeostasis. Int Immunol (2012) 24: 705–17. doi: 10.1093/intimm/dxs077 22875842 · DOI
  40. [40]Janssen E Tohme M Hedayat M Leick M Kumari S Ramesh N. A DOCK8-WIP-WASp Complex Links T Cell Receptors to the Actin Cytoskeleton. J Clin Invest (2016) 126: 3837–51. doi: 10.1172/JCI85774 PMC5096816 27599296 · DOI
  41. [41]Janssen E Tohme M Butts J Giguere S Sage PT Velázquez FE. DOCK8 Is Essential for LFA-1–Dependent Positioning of T Follicular Helper Cells in Germinal Centers. JCI Insight (2020) 5: 1– 13. doi: 10.1172/jci.insight.134508 PMC7455063 32573493 · DOI
  42. [42]Ruusala A Aspenström P. Isolation and Characterisation of DOCK8, a Member of the DOCK180-Related Regulators of Cell Morphology. FEBS Lett (2004) 572: 159–66. doi: 10.1016/j.febslet.2004.06.095 15304341 · DOI
  43. [43]Cook SA Comrie WA Poli MC Similuk M Oler AJ Faruqi AJ. HEM1 Deficiency Disrupts Mtorc2 and F-Actin Control in Inherited Immunodysregulatory Disease. Sci (80-) (2020) 369: 202–7. doi: 10.1126/science.aay5663 PMC8383235 32647003 · DOI · Paper page
  44. [44]Salzer E Zoghi S Kiss MG Kage F Rashkova C Stahnke S. The Cytoskeletal Regulator HEM1 Governs B Cell Development and Prevents Autoimmunity. Sci Immunol (2020) 5: 1– 16. doi: 10.1126/sciimmunol.abc3979 PMC7116756 32646852 · DOI · Paper page
  45. [45]Castro CN Rosenzwajg M Carapito R Shahrooei M Konantz M Khan A. NCKAP1L Defects Lead to a Novel Syndrome Combining Immunodeficiency, Lymphoproliferation, and Hyperinflammation. J Exp Med (2020) 217: 1– 18. doi: 10.1084/JEM.20192275 PMC7526481 32766723 · DOI · Paper page
  46. [46]Park H Staehling-Hampton K Appleby MW Brunkow ME Habib T Zhang Y. A Point Mutation in the Murine Heml Gene Reveals an Essential Role for Hematopoietic Protein 1 in Lymphopoiesis and Innate Immunity. J Exp Med (2008) 205: 2899–913. doi: 10.1084/jem.20080340 PMC2585840 19015308 · DOI · Paper page
  47. [47]Stahnke S Doering H Kusch C Nieswandt B Rottner K Stradal TEB. Loss of Hem1 Disrupts Macrophage Function and Impacts Migration, Phagocytosis, and Integrin- Mediated Adhesion. Curr Biol (2021) 31: 1– 14. doi: 10.1016/j.cub.2021.02.043 33711252 · DOI
  48. [48]Leithner A Eichner A Müller J Reversat A Brown M Schwarz J. Diversified Actin Protrusions Promote Environmental Exploration But Are Dispensable for Locomotion of Leukocytes. Nat Cell Biol (2016) 18: 1253–9. doi: 10.1038/ncb3426 27775702 · DOI · Paper page
  49. [49]Sprenkeler EGG Henriet SSV Tool ATJ Kreft IC van der Bijl I Aarts CEM. MKL1 Deficiency Results in a Severe Neutrophil Motility Defect Due to Impaired Actin Polymerization. Blood (2020) 135: 2171–81. doi: 10.1182/blood.2019002633 32128589 · DOI
  50. [50]Record J Malinova D Zenner HL Plagnol V Nowak K Syed F. Immunodeficiency and Severe Susceptibility to Bacterial Infection Associated With a Loss-of-Function Homozygous Mutation of MKL1. Blood (2015) 126: 1527–35. doi: 10.1182/blood-2014-12-611012 PMC4671330 26224645 · DOI
  51. [51]Lagresle-Peyrou C Luce S Ouchani F Soheili TS Sadek H Chouteau M. X-Linked Primary Immunodeficiency Associated With Hemizygous Mutations in the Moesin (MSN) Gene. J Allergy Clin Immunol (2016) 138: 1681– 1689.e8. doi: 10.1016/j.jaci.2016.04.032 27405666 · DOI
  52. [52]Nomachi A Yoshinaga M Liu J Kanchanawong P Tohyama K Thumkeo D. Moesin Controls Clathrin-Mediated S1PR1 Internalization in T Cells. PloS One (2013) 8: 1– 13. doi: 10.1371/journal.pone.0082590 PMC3865155 24358210 · DOI
  53. [53]Robertson TF Chengappa P Gomez Atria D Wu CF Avery L Roy NH. Lymphocyte Egress Signal Sphingosine-1-Phosphate Promotes ERM-Guided, Bleb-Based Migration. J Cell Biol (2021) 220: 1– 17. doi: 10.1083/jcb.202007182 PMC8006814 33764397 · DOI
  54. [54]Matsumoto M Hirata T. Moesin Regulates Neutrophil Rolling Velocity In Vivo. Cell Immunol (2016) 304– 305:59–62. doi: 10.1016/j.cellimm.2016.04.007 27131737 · DOI
  55. [55]Zehrer A Pick R Salvermoser M Boda A Miller M Stark K. Begandt D. A Fundamental Role of Myh9 for Neutrophil Migration in Innate Immunity. J Immunol (2018) 201: 1748–64. doi: 10.4049/jimmunol.1701400 30068598 · DOI
  56. [56]Jacobelli J Friedman RS Conti MA Lennon-Dumenil AM Piel M Sorensen CM. Confinement-Optimized Three-Dimensional T Cell Amoeboid Motility Is Modulated via Myosin IIA-Regulated Adhesions. Nat Immunol (2010) 11: 953–61. doi: 10.1038/ni.1936 PMC2943564 20835229 · DOI
  57. [57]Morin NA Oakes PW Hyun YM Lee D Chin EY King MR. Nonmuscle Myosin Heavy Chain IIA Mediates Integrin LFA-1 De-Adhesion During T Lymphocyte Migration. J Exp Med (2008) 205: 195– 205. doi: 10.1084/jem.20071543 18195072 PMC2234359 · DOI
  58. [58]Cortesio CL Wernimont SA Kastner DL Cooper KM Huttenlocher A. Impaired Podosome Formation and Invasive Migration of Macrophages From Patients With a PSTPIP1 Mutation and PAPA Syndrome. Arthritis Rheum (2010) 62: 2556–8. doi: 10.1002/art.27521.Impaired PMC2921034 20506269 · DOI
  59. [59]Starnes TW Bennin DA Bing X Eickhoff JC Grahf DC Bellak JM. The F-BAR Protein PSTPIP1 Controls Extracellular Matrix Degradation and Filopodia Formation in Macrophages. Blood (2014) 123: 2703–14. doi: 10.1182/blood-2013-07-516948 PMC3999755 24421327 · DOI
  60. [60]Janssen WJM Grobarova V Leleux J Jongeneel L van Gijn M van Montfrans JM. Proline-Serine-Threonine Phosphatase Interacting Protein 1 (PSTPIP1) Controls Immune Synapse Stability in Human T Cells. J Allergy Clin Immunol (2018) 142: 1947–55. doi: 10.1016/j.jaci.2018.01.030 29432774 · DOI
  61. [61]Takenawa T Suetsugu S. The WASP-WAVE Protein Network: Connecting the Membrane to the Cytoskeleton. Nat Rev Mol Cell Biol (2007) 8: 37– 48. doi: 10.1038/nrm2069 17183359 · DOI · Paper page
  62. [62]Hsu AP Donkó A Arrington ME Swamydas M Fink D Das A. Dominant Activating RAC2 Mutation With Lymphopenia, Immunodeficiency, and Cytoskeletal Defects. Blood (2019) 133: 1977–88. doi: 10.1182/blood-2018-11-886028 PMC6497516 30723080 · DOI
  63. [63]Lu X Zhang Y Liu F Wang L. Rac2 Regulates the Migration of T Lymphoid Progenitors to the Thymus During Zebrafish Embryogenesis. J Immunol (2020) 204: 2447–54. doi: 10.4049/jimmunol.1901494 32198141 · DOI
  64. [64]Deng Q Yoo SK Cavnar PJ Green JM Huttenlocher A. Dual Roles for Rac2 in Neutrophil Motility and Active Retention in Zebrafish Hematopoietic Tissue. Dev Cell (2011) 21: 735–45. doi: 10.1016/j.devcel.2011.07.013 PMC3199325 22014524 · DOI
  65. [65]Croker BA Handman E Hayball JD Baldwin TM Voigt V Cluse LA. Rac2-Deficient Mice Display Perturbed T-Cell Distribution and Chemotaxis, But Only Minor Abnormalities in TH1 Responses. Immunol Cell Biol (2002) 80: 231–40. doi: 10.1046/j.1440-1711.2002.01077.x 12067410 · DOI
  66. [66]Roberts AW Chaekyun K Zhen L Lowe JB Kapur R Petryniak B. Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense. Immunity (1999) 10: 183–96. doi: 10.1016/S1074-7613(00)80019-9 10072071 · DOI · Paper page
  67. [67]Salzer E Cagdas D Hons M Mace EM Garncarz W Petronczki ÖY. RASGRP1 Deficiency Causes Immunodeficiency With Impaired Cytoskeletal Dynamics. Nat Immunol (2016) 17: 1352–60. doi: 10.1038/ni.3575 PMC6400263 27776107 · DOI
  68. [68]Kalinichenko A Perinetti Casoni G Dupré L Trotta L Huemer J Galgano D. RhoG Deficiency Abrogates Cytotoxicity of Human Lymphocytes and Causes Hemophagocytic Lymphohistiocytosis. Blood (2021) 137: 2033–45. doi: 10.1182/blood.2020008738 PMC8057258 33513601 · DOI
  69. [69]Crequer A Troeger A Patin E Ma CS Picard C Pedergnana V. Human RHOH Deficiency Causes T Cell Defects and Susceptibility to EV-HPV Infections. J Clin Invest (2012) 122: 3239–47. doi: 10.1172/JCI62949 PMC3428089 22850876 · DOI · Paper page
  70. [70]Chae HD Lee KE Williams DA Gu Y. Cross-Talk Between RhoH and Rac1 in Regulation of Actin Cytoskeleton and Chemotaxis of Hematopoietic Progenitor Cells. Blood (2008) 111: 2597–605. doi: 10.1182/blood-2007-06-093237 PMC2254535 18089848 · DOI · Paper page
  71. [71]Dang TS Willet JDP Griffin HR Morgan NV O’Boyle G Arkwright PD. Defective Leukocyte Adhesion and Chemotaxis Contributes to Combined Immunodeficiency in Humans With Autosomal Recessive MST1 Deficiency. J Clin Immunol (2016) 36: 117–22. doi: 10.1007/s10875-016-0232-2 PMC4769310 26801501 · DOI
  72. [72]Nehme NT Schmid JP Debeurme F André-Schmutz I Lim A Nitschke P. MST1 Mutations in Autosomal Recessive Primary Immunodeficiency Characterized by Defective Naive T-Cell Survival. Blood (2012) 119: 3458–68. doi: 10.1182/blood-2011-09-378364 PMC3824282 22174160 · DOI
  73. [73]Katagiri K Katakai T Ebisuno Y Ueda Y Okada T Kinashi T. Mst1 Controls Lymphocyte Trafficking and Interstitial Motility Within Lymph Nodes. EMBO J (2009) 28: 1319–31. doi: 10.1038/emboj.2009.82 PMC2683056 19339990 · DOI
  74. [74]Dong Y Du X Ye J Han M Xu T Zhuang Y. Tao W. A Cell-Intrinsic Role for Mst1 in Regulating Thymocyte Egress. J Immunol (2009) 183: 3865–72. doi: 10.4049/jimmunol.0900678 19692642 · DOI
  75. [75]Lemoine R Pachlopnik-Schmid J Farin HF Bigorgne A Debré M Sepulveda F. Immune Deficiency-Related Enteropathy-Lymphocytopenia-Alopecia Syndrome Results From Tetratricopeptide Repeat Domain 7A Deficiency. J Allergy Clin Immunol (2014) 134: 1354– 64.e6. doi: 10.1016/j.jaci.2014.07.019 25174867 · DOI
  76. [76]Westerberg L Larsson M Hardy SJ Fernández C Thrasher AJ Severinson E. Wiskott-Aldrich Syndrome Protein Deficiency Leads to Reduced B-Cell Adhesion, Migration, and Homing, and a Delayed Humoral Immune Response. Blood (2005) 105: 1144–52. doi: 10.1182/blood-2004-03-1003 15383456 · DOI
  77. [77]Castiello MC Bosticardo M Pala F Catucci M Chamberlain N Van Zelm MC. Wiskott-Aldrich Syndrome Protein Deficiency Perturbs the Homeostasis of B-Cell Compartment in Humans. J Autoimmun (2014) 50: 42– 50. doi: 10.1016/j.jaut.2013.10.006 24369837 PMC4012141 · DOI
  78. [78]Snover DC Frizzera G Spector BD Perry GS Kersey JH. Wiskott-Aldrich Syndrome: Histopathologic Findings in the Lymph Nodes and Spleens of 15 Patients. Hum Pathol (1981) 12: 821–31. doi: 10.1016/S0046-8177(81)80085-8 6975749 · DOI
  79. [79]Binks M Jones GE Brickell PM Kinnon C Katz DR Thrasher AJ. Intrinsic Dendritic Cell Abnormalities in Wiskott-Aldrich Syndrome. Eur J Immunol (1998) 28: 3259–67. doi: 10.1002/(SICI)1521-4141(199810)28:10<3259::AID-IMMU3259>3.0.CO;2-B 9808195 · DOI
  80. [80]Burns S Thrasher AJ Blundell MP Machesky L Jones GE. Configuration of Human Dendritic Cell Cytoskeleton by Rho GTPases, the WAS Protein, and Differentiation. Blood (2001) 98: 1142–9. doi: 10.1182/blood.V98.4.1142 11493463 · DOI
  81. [81]Badolato R Sozzani S Malacarne F Bresciani S Fiorini M Borsatti A. Monocytes From Wiskott-Aldrich Patients Display Reduced Chemotaxis and Lack of Cell Polarization in Response to Monocyte Chemoattractant Protein-1 and Formyl-Methionyl-Leucyl-Phenylalanine. J Immunol (1998) 161: 1026–33. 9670984
  82. [82]Stabile H Carlino C Mazza C Giliani S Morrone S Notarangelo LD. Impaired NK-Cell Migration in WAS/XLT Patients: Role of Cdc42/WASp Pathway in the Control of Chemokine-Induced β2 Integrin High-Affinity State. Blood (2010) 115: 2818–26. doi: 10.1182/blood-2009-07-235804 PMC2854428 20130240 · DOI
  83. [83]Zhang H Schaff UY Green CE Chen H Sarantos MR Hu Y. Impaired Integrin-Dependent Function in Wiskott-Aldrich Syndrome Protein-Deficient Murine and Human Neutrophils. Immunity (2006) 25: 285–95. doi: 10.1016/j.immuni.2006.06.014 PMC4698343 16901726 · DOI
  84. [84]Linder S Nelson D Weiss M Aepfelbacher M. Wiskott-Aldrich Syndrome Protein Regulates Podosomes in Primary Human Macrophages. Proc Natl Acad Sci USA (1999) 96: 9648–53. doi: 10.1073/pnas.96.17.9648 PMC22264 10449748 · DOI
  85. [85]Haddad E Zugaza JL Louache F Debili N Crouin C Schwarz K. The Interaction Between Cdc42 and WASP Is Required for SDF-1-Induced T-Lymphocyte Chemotaxis. Blood (2001) 97: 33–8. doi: 10.1182/blood.V97.1.33 11133739 · DOI
  86. [86]Trifari S Scaramuzza S Catucci M Ponzoni M Mollica L Chiesa R. Revertant T Lymphocytes in a Patient With Wiskott-Aldrich Syndrome: Analysis of Function and Distribution in Lymphoid Organs. J Allergy Clin Immunol (2010) 125: 439– 48.e8. doi: 10.1016/j.jaci.2009.11.034 20159256 · DOI
  87. [87]Houmadi R Guipouy D Rey-Barroso J Vasconcelos Z Cornet J Manghi M. The Wiskott-Aldrich Syndrome Protein Contributes to the Assembly of the LFA-1 Nanocluster Belt at the Lytic Synapse. Cell Rep (2018) 22: 979–91. doi: 10.1016/j.celrep.2017.12.088 29386139 · DOI
  88. [88]Lafouresse F Cotta-de-Almeida V Malet-Engra G Galy A Valitutti S Dupré L. Wiskott-Aldrich Syndrome Protein Controls Antigen-Presenting Cell-Driven CD4 + T-Cell Motility by Regulating Adhesion to Intercellular Adhesion Molecule-1. Immunology (2012) 137: 183–96. doi: 10.1111/j.1365-2567.2012.03620.x PMC3461399 22804504 · DOI
  89. [89]Carman CV Sage PT Sciuto TE de la Fuente MA Geha RS Ochs HDD. Transcellular Diapedesis Is Initiated by Invasive Podosomes. Immunity (2007) 26: 784–97. doi: 10.1016/j.immuni.2007.04.015 PMC2094044 17570692 · DOI
  90. [90]German Y Vulliard L Kamnev A Pfajfer L Huemer J Mautner A-K. Morphological Profiling of Human T and NK Lymphocytes by High-Content Cell Imaging. Cell Rep (2021) 36: 1– 14. doi: 10.1016/j.celrep.2021.109318 34233185 · DOI
  91. [91]De Noronha S Hardy S Sinclair J Blundell MP Strid J Schulz O. Impaired Dendritic-Cell Homing In Vivo in the Absence of Wiskott-Aldrich Syndrome Protein. Blood (2005) 105: 1590–7. doi: 10.1182/blood-2004-06-2332 15494425 · DOI
  92. [92]Bouma G Burns S Thrasher AJ. Impaired T-Cell Priming In Vivo Resulting From Dysfunction of WASp-Deficient Dendritic Cells. Blood (2007) 110: 4278–84. doi: 10.1182/blood-2007-06-096875 17673604 · DOI
  93. [93]Lacout C Haddad E Sabri S Svinarchouk F Garçon L Capron C. A Defect in Hematopoietic Stem Cell Migration Explains the Nonrandom X-Chromosome Inactivation in Carriers of Wiskott-Aldrich Syndrome. Blood (2003) 102: 1282–9. doi: 10.1182/blood-2002-07-2099 12730112 · DOI
  94. [94]Dovas A Gevrey JC Grossi A Park H Abou-Kheir W Cox D. Regulation of Podosome Dynamics by WASp Phosphorylation: Implication in Matrix Degradation and Chemotaxis in Macrophages. J Cell Sci (2009) 122: 3873–82. doi: 10.1242/jcs.051755 PMC2773189 19808890 · DOI
  95. [95]Sabri S Foudi A Boukour S Franc B Charrier S Jandrot-Perrus M. Deficiency in the Wiskott-Aldrich Protein Induces Premature Proplatelet Formation and Platelet Production in the Bone Marrow Compartment. Blood (2006) 108: 134–40. doi: 10.1182/blood-2005-03-1219 16522820 · DOI
  96. [96]Snapper SB Meelu P Nguyen D Stockton BM Bozza P Alt FW. WASP Deficiency Leads to Global Defects of Directed Leukocyte Migration In Vitro and In Vivo. J Leukoc Biol (2005) 77: 993–8. doi: 10.1189/jlb.0804444 15774550 · DOI
  97. [97]Keszei M Record J Kritikou JS Wurzer H Geyer C Thiemann M. Constitutive Activation of WASp in X-Linked Neutropenia Renders Neutrophils Hyperactive. J Clin Invest (2018) 128: 4115–31. doi: 10.1172/JCI64772 PMC6118594 30124469 · DOI
  98. [98]Oliveira MMS Kung S Moreau HD Maurin M Record J Sanséau D. The WASp L272P Gain-of-Function Mutation Alters Dendritic Cell Coordination of Actin Dynamics for Migration and Adhesion. J Leukoc Biol (2021), 1– 11. doi: 10.1002/jlb.1ab0821-013rr 34431547 · DOI
  99. [99]Pfajfer L Mair NK Gulez N Rey-barroso J Ijspeert H Tangye SG. Mutations Affecting the Actin Regulator WD Repeat – Containing Protein 1 Lead to Aberrant Lymphoid Immunity. J Allergy Clin Immunol (2018) 142: 1589–604.e11. doi: 10.1016/j.jaci.2018.04.023 29751004 · DOI
  100. [100]Standing ASI Malinova D Hong Y Record J Moulding D Blundell MP. Autoinflammatory Periodic Fever, Immunodeficiency, and Thrombocytopenia (PFIT) Caused by Mutation in Actinregulatory Gene WDR1. J Exp Med (2017) 214: 59– 71. doi: 10.1084/jem.20161228 27994071 PMC5206503 · DOI
  101. [101]Kuhns DB Fink DL Choi U Sweeney C Lau K Priel DL. Cytoskeletal Abnormalities and Neutrophil Dysfunction in WDR1 Deficiency. Blood (2016) 128: 2135–43. doi: 10.1182/blood-2016-03-706028 PMC5084607 27557945 · DOI
  102. [102]Kile BT Panopoulos AD Stirzaker RA Hacking DF Tahtamouni LH Willson TA. Mutations in the Cofilin Partner Aip1/Wdr1 Cause Autoinflammatory Disease and Macrothrombocytopenia. Blood (2007) 110: 2371–80. doi: 10.1182/blood-2006-10-055087 PMC1988957 17515402 · DOI
  103. [103]Pfajfer L Seidel MG Houmadi R Boztug K Dupré L. WIP Deficiency Severely Affects Human Lymphocyte Architecture During Migration and Synapse Assembly. Blood (2018) 130: 1949–54. doi: 10.1182/blood-2017-04-777383 28903942 · DOI
  104. [104]Chou HC Antón IM Holt MR Curcio C Lanzardo S Worth A. WIP Regulates the Stability and Localization of WASP to Podosomes in Migrating Dendritic Cells. Curr Biol (2006) 16: 2337–44. doi: 10.1016/j.cub.2006.10.037 PMC1885947 17141616 · DOI
  105. [105]Tsuboi S. Requirement for a Complex of Wiskott-Aldrich Syndrome Protein (WASP) With WASP Interacting Protein in Podosome Formation in Macrophages. J Immunol (2007) 178: 2987–95. doi: 10.4049/jimmunol.178.5.2987 PMC1855218 17312144 · DOI
  106. [106]Ciriza J Thompson H Petrosian R Manilay JO García-Ojeda ME. The Migration of Hematopoietic Progenitors From the Fetal Liver to the Fetal Bone Marrow: Lessons Learned and Possible Clinical Applications. Exp Hematol (2013) 41: 411–23. doi: 10.1016/j.exphem.2013.01.009 23395775 · DOI
  107. [107]Bonaud A Lemos JP Espéli M Balabanian K. Hematopoietic Multipotent Progenitors and Plasma Cells: Neighbors or Roommates in the Mouse Bone Marrow Ecosystem? Front Immunol (2021) 12: 658535. doi: 10.3389/fimmu.2021.658535 33936091 PMC8083056 · DOI
  108. [108]Lévesque JP Helwani FM Winkler IG. The Endosteal Osteoblastic Niche and Its Role in Hematopoietic Stem Cell Homing and Mobilization. Leukemia (2010) 24: 1979–92. doi: 10.1038/leu.2010.214 20861913 · DOI
  109. [109]Upadhaya S Krichevsky O Akhmetzyanova I Sawai CM Fooksman DR Reizis B. Intravital Imaging Reveals Motility of Adult Hematopoietic Stem Cells in the Bone Marrow Niche. J Clean Prod (2020) 27: 336– 345.e4. doi: 10.1016/j.stem.2020.06.003 PMC7415613 32589864 · DOI
  110. [110]James KD Jenkinson WE. Anderson G. T-Cell Egress From the Thymus: Should I Stay or Should I Go? J Leukoc Biol (2018) 104: 275–84. doi: 10.1002/JLB.1MR1217-496R PMC6174998 29485734 · DOI
  111. [111]Lougaris V Baronio M Gazzurelli L Benvenuto A Plebani A. RAC2 and Primary Human Immune Deficiencies. J Leukoc Biol (2020) 108: 687–96. doi: 10.1002/JLB.5MR0520-194RR 32542921 · DOI
  112. [112]Lambe T Crawford G Johnson AL Crockford TL Bouriez-Jones T Smyth AM. DOCK8 Is Essential for T-Cell Survival and the Maintenance of CD8 + T-Cell Memory. Eur J Immunol (2011) 41: 3423–35. doi: 10.1002/eji.201141759 PMC3517112 21969276 · DOI
  113. [113]Randall KL Lambe T Johnson A Treanor B Kucharska E Domaschenz H. Dock8 Mutations Cripple B Cell Immunological Synapses, Germinal Centers and Long-Lived Antibody Production. Nat Immunol (2009) 10: 1283–91. doi: 10.1038/ni.1820 PMC3437189 19898472 · DOI
  114. [114]Pillay BA Fusaro M Gray PE Statham AL Burnett L Bezrodnik L. Somatic Reversion of Pathogenic DOCK8 Variants Alters Lymphocyte Differentiation and Function to Effectively Cure DOCK8 Deficiency. J Clin Invest (2021) 131: 1– 17. doi: 10.1172/JCI142434 PMC7843233 33290277 · DOI
  115. [115]Xu X Wang X Todd EM Jaeger ER Vella JL Mooren OL. Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration. J Immunol (2016) 197: 1683–91. doi: 10.4049/jimmunol.1600874 PMC4992580 27465533 · DOI
  116. [116]Notarangelo LD. Primary Immunodeficiencies. J Allergy Clin Immunol (2010) 125: S182–94. doi: 10.1016/j.jaci.2009.07.053 20042228 · DOI
  117. [117]Beel K Cotter MM Blatny J Bond J Lucas G Green F. A Large Kindred With X-Linked Neutropenia With an I294T Mutation of the Wiskott-Aldrich Syndrome Gene. Br J Haematol (2009) 144: 120–6. doi: 10.1111/j.1365-2141.2008.07416.x PMC3125974 19006568 · DOI
  118. [118]Fowell DJ Kim M. The Spatio-Temporal Control of Effector T Cell Migration. Nat Rev Immunol (2021) 21: 582–96. doi: 10.1038/s41577-021-00507-0 PMC9380693 33627851 · DOI
  119. [119]Aydin SE Kilic SS Aytekin C Kumar A Porras O Kainulainen L. DOCK8 Deficiency: Clinical and Immunological Phenotype and Treatment Options - a Review of 136 Patients. J Clin Immunol (2015) 35: 189–98. doi: 10.1007/s10875-014-0126-0 25627830 · DOI
  120. [120]Su HC Jing H Angelus P Freeman AF. Insights Into Immunity From Clinical and Basic Science Studies of DOCK8 Immunodeficiency Syndrome. Immunol Rev (2019) 287: 9– 19. doi: 10.1111/imr.12723 30565250 PMC6350515 · DOI
  121. [121]Schneider C Shen C Gopal AA Douglas T Forestell B Kauffman KD. Migration-Induced Cell Shattering Due to DOCK8 Deficiency Causes a Type 2–Biased Helper T Cell Response. Nat Immunol (2020) 21: 1528–39. doi: 10.1038/s41590-020-0795-1 PMC10478007 33020661 · DOI · Paper page
  122. [122]Weninger W Biro M Jain R. Leukocyte Migration in the Interstitial Space of Non-Lymphoid Organs. Nat Rev Immunol (2014) 14: 232–46. doi: 10.1038/nri3641 24603165 · DOI
  123. [123]Ley K Laudanna C Cybulsky MI Nourshargh S. Getting to the Site of Inflammation: The Leukocyte Adhesion Cascade Updated. Nat Rev Immunol (2007) 7: 678–89. doi: 10.1038/nri2156 17717539 · DOI · Paper page
  124. [124]Miralles F Posern G Zaromytidou AI Treisman R. Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL. Cell (2003) 113: 329–42. doi: 10.1016/S0092-8674(03)00278-2 12732141 · DOI · Paper page
  125. [125]Vartiainen MK Guettler S Larijani B Treisman R. Nuclear Actin Regulates Dynamic Subcellular Localization and Activity of the SRF Cofactor MAL. Sci (80-) (2007) 316: 1749–52. doi: 10.1126/science.1141084 17588931 · DOI
  126. [126]Martinelli R Zeiger AS Whitfield M Sciuto TE Dvorak A van Vliet KJ. Probing the Biomechanical Contribution of the Endothelium to Lymphocyte Migration: Diapedesis by the Path of Least Resistance. J Cell Sci (2014) 127: 3720–34. doi: 10.1242/jcs.148619 PMC4150060 25002404 · DOI
  127. [127]Alon R van Buul JD. Leukocyte Breaching of Endothelial Barriers: The Actin Link. Trends Immunol (2017) 38: 606–15. doi: 10.1016/j.it.2017.05.002 28559148 · DOI
  128. [128]Côté JF Chung PL Théberge JF Hallé M Spencer S Lasky LA. PSTPIP Is a Substrate of PTP-PEST and Serves as a Scaffold Guiding PTP-PEST Toward a Specific Dephosphorylation of WASP. J Biol Chem (2002) 277: 2973–86. doi: 10.1074/jbc.M106428200 11711533 · DOI
  129. [129]Badour K Zhang J Shi F Leng Y Collins M Siminovitch KA. Fyn and PTP-PEST-Mediated Regulation of Wiskott-Aldrich Syndrome Protein (WASp) Tyrosine Phosphorylation Is Required for Coupling T Cell Antigen Receptor Engagement to WASp Effector Function and T Cell Activation. J Exp Med (2004) 199: 99– 111. doi: 10.1084/jem.20030976 14707117 PMC1887720 · DOI
  130. [130]Gardel ML Schneider IC Aratyn-schaus Y Waterman CM Engineering B Biology C. Mechanical Integration of Actin and Adhesion Dynamics in Cell Migration. Annu Rev Cell Dev Biol (2010) 26: 315–33. doi: 10.1146/annurev.cellbio.011209.122036.Mechanical PMC4437624 19575647 · DOI
  131. [131]Plotnikov SV Waterman CM. Guiding Cell Migration by Tugging. Curr Opin Cell Biol (2013) 25: 619–26. doi: 10.1016/j.ceb.2013.06.003 PMC3827722 23830911 · DOI
  132. [132]Reversat A Gaertner F Merrin J Stopp J Tasciyan S Aguilera J. Cellular Locomotion Using Environmental Topography. Nature (2020) 582: 582–5. doi: 10.1038/s41586-020-2283-z 32581372 · DOI
  133. [133]Blumenthal D Burkhardt JK. Multiple Actin Networks Coordinate Mechanotransduction at the Immunological Synapse. J Cell Biol (2020) 219: 1– 12. doi: 10.1083/jcb.201911058 PMC7041673 31977034 · DOI
  134. [134]Sims TN Soos TJ Xenias HS Dubin-Thaler B Hofman JM Waite JC. Opposing Effects of Pkcθ and WASp on Symmetry Breaking and Relocation of the Immunological Synapse. Cell (2007) 129: 773–85. doi: 10.1016/j.cell.2007.03.037 17512410 · DOI
  135. [135]Calvez R Lafouresse F de Meester J Galy A Valitutti S Dupré L. The Wiskott-Aldrich Syndrome Protein Permits Assembly of a Focused Immunological Synapse Enabling Sustained T-Cell Receptor Signaling. Haematologica (2011) 96: 1415–23. doi: 10.3324/haematol.2011.040204 PMC3186301 21659358 · DOI
  136. [136]Kumari S Mak M Poh Y Tohme M Watson N Melo M. Cytoskeletal Tension Actively Sustains the Migratory T-Cell Synaptic Contact. EMBO J (2020) 39: 1– 18. doi: 10.15252/embj.2019102783 PMC7049817 31894880 · DOI
  137. [137]Ackerknecht M Gollmer K Germann P Ficht X Abe J Fukui Y. Antigen Availability and DOCK2-Driven Motility Govern CD4 + T Cell Interactions With Dendritic Cells In Vivo. J Immunol (2017) 199: 520–30. doi: 10.4049/jimmunol.1601148 28607113 · DOI
  138. [138]Krause M Gautreau A. Steering Cell Migration: Lamellipodium Dynamics and the Regulation of Directional Persistence. Nat Rev Mol Cell Biol (2014) 15: 577–90. doi: 10.1038/nrm3861 25145849 · DOI
  139. [139]Dustin ML Long EO. Cytotoxic Immunological Synapses. Immunol Rev (2010) 235: 24– 34. doi: 10.1111/j.0105-2896.2010.00904.x 20536553 PMC2950621 · DOI
  140. [140]Welch MD DePace AH Verma S Iwamatsu A Mitchison TJ. The Human Arp2/3 Complex Is Composed of Evolutionarily Conserved Subunits and Is Localized to Cellular Regions of Dynamic Actin Filament Assembly. J Cell Biol (1997) 138: 375–84. doi: 10.1083/jcb.138.2.375 PMC2138188 9230079 · DOI
  141. [141]Obeidy P Ju LA Oehlers SH Zulkhernain NS Lee Q Ni JLG. Partial Loss of Actin Nucleator Actin Related Protein 2/3 Activity Triggers Blebbing in Primary T Lymphocytes. Immunol Cell Biol (2020) 98: 93– 113. doi: 10.1111/imcb.12304 31698518 PMC7028084 · DOI
  142. [142]Machesky LM Insall RH. Scar1 and the Related Wiskott-Aldrich Syndrome Protein, WASP, Regulate the Actin Cytoskeleton Through the Arp2/3 Complex. Curr Biol (1998) 8: 1347–56. doi: 10.1016/S0960-9822(98)00015-3 9889097 · DOI
  143. [143]Padrick SB Doolittle LK Brautigam CA King DS Rosen MK. Arp2/3 Complex Is Bound and Activated by Two WASP Proteins. Proc Natl Acad Sci USA (2011) 108: E472-9. doi: 10.1073/pnas.1100236108 21676863 PMC3158169 · DOI
  144. [144]De La Fuente MA Sasahara Y Calamito M Antón IM Elkhal A Gallego MD. WIP Is a Chaperone for Wiskott-Aldrich Syndrome Protein (WASP). Proc Natl Acad Sci USA (2007) 104: 926–31. doi: 10.1073/pnas.0610275104 PMC1783416 17213309 · DOI
  145. [145]Higgs HN Pollard TD. Regulation of Actin Filament Network Formation Through Arp2/3 Complex: Activation by a Diverse Array of Proteins. Annu Rev Biochem (2001) 70: 649–76. doi: 10.1146/annurev.biochem.70.1.649 11395419 · DOI
  146. [146]Pollitt AY Insall RH. WASP and SCAR/WAVE Proteins: The Drivers of Actin Assembly. J Cell Sci (2009) 122: 2575–8. doi: 10.1242/jcs.023879 PMC2954249 19625501 · DOI
  147. [147]Rey-Barroso J Calovi DS Combe M German Y Moreau M Canivet A. Switching Between Individual and Collective Motility in B Lymphocytes Is Controlled by Cell-Matrix Adhesion and Inter-Cellular Interactions. Sci Rep (2018) 8: 1– 16. doi: 10.1038/s41598-018-24222-4 29643414 PMC5895587 · DOI
  148. [148]Ambruso DR Knall C Abell AN Panepinto J Kurkchubasche A Thurman G. Human Neutrophil Immunodeficiency Syndrome Is Associated With an Inhibitory Rac2 Mutation. Proc Natl Acad Sci USA (2000) 97: 4654–9. doi: 10.1073/pnas.080074897 PMC18288 10758162 · DOI
  149. [149]Accetta D Syverson G Bonacci B Reddy S Bengtson C Surfus J. Human Phagocyte Defect Caused by a Rac2 Mutation Detected by Means of Neonatal Screening for T-Cell Lymphopenia. J Allergy Clin Immunol (2011) 127: 535– 38.e2. doi: 10.1016/j.jaci.2010.10.013 21167572 · DOI
  150. [150]Alkhairy OK Rezaei N Graham RR Abolhassani H Borte S Hultenby K. RAC2 Loss-of-Function Mutation in 2 Siblings With Characteristics of Common Variable Immunodeficiency. J Allergy Clin Immunol (2015) 135: 1380– 4.e5. doi: 10.1016/j.jaci.2014.10.039 25512081 PMC4426222 · DOI
  151. [151]Mattila PK Lappalainen P. Filopodia: Molecular Architecture and Cellular Functions. Nat Rev Mol Cell Biol (2008) 9: 446–54. doi: 10.1038/nrm2406 18464790 · DOI
  152. [152]Kress H Stelzer EHK Holzer D Buss F Griffiths G Rohrbach A. Filopodia Act as Phagocytic Tentacles and Pull With Discrete Steps and a Load-Dependent Velocity. Proc Natl Acad Sci USA (2007) 104: 11633–8. doi: 10.1073/pnas.0702449104 PMC1913848 17620618 · DOI
  153. [153]Krugmann S Jordens I Gevaert K Driessens M Vandekerckhove J Hall A. Cdc42 Induces Filopodia by Promoting the Formation of an IRSp53:Mena Complex. Curr Biol (2001) 11: 1645–55. doi: 10.1016/S0960-9822(01)00506-1 11696321 · DOI
  154. [154]Sánchez-Madrid F Serrador JM. Bringing Up the Rear: Defining the Roles of the Uropod. Nat Rev Mol Cell Biol (2009) 10: 353–9. doi: 10.1038/nrm2680 19373240 · DOI
  155. [155]Smith LA Aranda-Espinoza H Haun JB Dembo M Hammer DA. Neutrophil Traction Stresses Are Concentrated in the Uropod During Migration. Biophys J (2007) 92: L58–60. doi: 10.1529/biophysj.106.102822 PMC1864841 17218464 · DOI
  156. [156]Jacobelli J Bennett FC Pandurangi P Tooley AJ Krummel MF. Myosin-IIA and ICAM-1 Regulate the Interchange Between Two Distinct Modes of T Cell Migration. J Immunol (2009) 182: 2041–50. doi: 10.4049/jimmunol.0803267 19201857 · DOI
  157. [157]Syndrome Consortium T. Mutations in MYH9result in the May-Hegglin Anomaly, and Fechtner and Sebastian Syndromes. Nat Genet (2000) 26: 103–5. doi: 10.1038/79063 10973259 · DOI
  158. [158]Murphy DA Courtneidge SA. The “Ins” and “Outs” of Podosomes and Invadopodia: Characteristics, Formation and Function. Nat Rev Mol Cell Biol (2011) 12: 413–26. doi: 10.1038/nrm3141 PMC3423958 21697900 · DOI
  159. [159]Jones GE Zicha D Dunn GA Blundell M Thrasher A. Restoration of Podosomes and Chemotaxis in Wiskott-Aldrich Syndrome Macrophages Following Induced Expression of WASp. Int J Biochem Cell Biol (2002) 34: 806–15. doi: 10.1016/S1357-2725(01)00162-5 11950596 · DOI
  160. [160]Olivier A Jeanson-Leh L Bouma G Compagno D Blondeau J Seye K. A Partial Down-Regulation of WASP Is Sufficient to Inhibit Podosome Formation in Dendritic Cells. Mol Ther (2006) 13: 729–37. doi: 10.1016/j.ymthe.2005.11.003 16360341 · DOI
  161. [161]Alexander E Sanders S Braylan R. Purported Difference Between Human T- and B-Cell Surface Morphology Is an Artefact. Nature (1976) 261: 239–41. doi: 10.1038/261239a0 1083959 · DOI
  162. [162]Parakkal P Pinto J Hanifin JM. Surface Morphology of Human Mononuclear Phagocytes During Maturation and Phagocytosis. J Ultrasructure Res (1974) 48: 216–26. doi: 10.1016/S0022-5320(74)80078-X 4602910 · DOI
  163. [163]Fisher PJ Bulur PA Vuk-Pavlovic S Prendergast FG Dietz AB. Dendritic Cell Microvilli: A Novel Membrane Structure Associated With the Multifocal Synapse and T-Cell Clustering. Blood (2008) 112: 5037–45. doi: 10.1182/blood-2008-04-149526 18805966 · DOI
  164. [164]Orbach R Su X. Surfing on Membrane Waves: Microvilli, Curved Membranes, and Immune Signaling. Front Immunol (2020) 11: 2187. doi: 10.3389/fimmu.2020.02187 33013920 PMC7516127 · DOI
  165. [165]Ghosh S Di Bartolo V Tubul L Shimoni E Kartvelishvily E Dadosh T. ERM-Dependent Assembly of T Cell Receptor Signaling and Co-Stimulatory Molecules on Microvilli Prior to Activation. Cell Rep (2020) 30: 3434– 3447.e6. doi: 10.1016/j.celrep.2020.02.069 32160548 · DOI
  166. [166]Kenney DM Cairns L Remold-O’donnell E Peterson J Rosen FS Parkman R. Morphological Abnormalities in the Lympcytes of Patients the Wiskott-Aldrich Syndrome. Blood (1986) 68: 1329–32. doi: 10.1182/blood.V68.6.1329.1329 3779101 · DOI
  167. [167]Molina IJ Kenney DM Rosen FS Remold-O’donnell E. T Cell Lines Characterize Events in the Pathogenesis of the Wiskott-Aldrich Syndrome. J Exp Med (1992) 176: 867–74. doi: 10.1084/jem.176.3.867 PMC2119357 1512549 · DOI
  168. [168]Majstoravich S Zhang J Nicholson-Dykstra S Linder S Friedrich W Siminovitch KA. Lymphocyte Microvilli Are Dynamic, Actin-Dependent Structures That do Not Require Wiskott-Aldrich Syndrome Protein (WASp) for Their Morphology. Blood (2004) 104: 1396–403. doi: 10.1182/blood-2004-02-0437 15130947 · DOI
  169. [169]McGregor AL Hsia CR Lammerding J. Squish and Squeeze - the Nucleus as a Physical Barrier During Migration in Confined Environments. Curr Opin Cell Biol (2016) 40: 32– 40. doi: 10.1016/j.ceb.2016.01.011 26895141 PMC4887392 · DOI
  170. [170]Sneider A Hah J Wirtz D Kim DH. Recapitulation of Molecular Regulators of Nuclear Motion During Cell Migration. Cell Adhes Migr (2019) 13: 50– 62. doi: 10.1080/19336918.2018.1506654 PMC6527386 30261154 · DOI
  171. [171]Yamada KM Sixt M. Mechanisms of 3D Cell Migration. Nat Rev Mol Cell Biol (2019) 20: 738–52. doi: 10.1038/s41580-019-0172-9 31582855 · DOI
  172. [172]Renkawitz J Kopf A Stopp J de Vries I Driscoll MK Merrin J. Nuclear Positioning Facilitates Amoeboid Migration Along the Path of Least Resistance. Nature (2019) 568: 546–50. doi: 10.1038/s41586-019-1087-5 PMC7217284 30944468 · DOI
  173. [173]Jacobelli J Estin Matthews M Chen S Krummel MF. Activated T Cell Trans-Endothelial Migration Relies on Myosin-IIA Contractility for Squeezing the Cell Nucleus Through Endothelial Cell Barriers. PloS One (2013) 8: 1– 13. doi: 10.1371/journal.pone.0075151 PMC3777879 24069389 · DOI
  174. [174]Thompson SB Sandor AM Lui V Chung JW Waldman MM Long RA. Formin-Like 1 Mediates Effector T Cell Trafficking to Inflammatory Sites to Enable T Cell-Mediated Autoimmunity. Elife (2020) 9: 1– 27. doi: 10.7554/eLife.58046 PMC7308091 32510333 · DOI
  175. [175]Maritzen T Schachtner H Legler DF. On the Move: Endocytic Trafficking in Cell Migration. Cell Mol Life Sci (2015) 72: 2119–34. doi: 10.1007/s00018-015-1855-9 PMC11113590 25681867 · DOI
  176. [176]Zech T Calaminus SDJ Machesky LM. Actin on Trafficking: Could Actin Guide Directed Receptor Transport? Cell Adhes Migr (2012) 6: 476–81. doi: 10.4161/cam.21373 PMC3547890 23076144 · DOI
  177. [177]Piperno GM Naseem A Silvestrelli G Amadio R Caronni N Cervantes-Luevano KE. Wiskott-Aldrich Syndrome Protein Restricts cGAS/STING Activation by dsDNA Immune Complexes. JCI Insight (2020) 5: e132857. doi: 10.1172/jci.insight.132857 PMC7526445 32721945 · DOI

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Authors
Kamnev, A., Lacouture, C., Fusaro, M., & Dupré, L.
Affiliations
  • Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (AT)
  • Centre National de la Recherche Scientifique (FR)
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Venue
Frontiers in Immunology
Publisher
Frontiers Media SA
Published
2021-11-15
Volume
12
Pages
750537-750537
ISSN
1664-3224 (ISSN-L)
DOI
10.3389/fimmu.2021.750537
PMC
PMC8634686
OpenAlex
W3213163826
Cited by
38
References
0
Citations by year
2026: 5 · 2025: 14 · 2024: 12 · 2023: 3 · 2022: 4
FWCI
0.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Vienna Science and Technology Fund (LS16-060)
  • Centre National de la Recherche Scientifique
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Keywords
actin cytoskeleton dynamics, leukocyte migration, immune cell motility, primary immunodeficiency, actinopathy, actin regulators, immune cell development
MeSH terms
Actins, Animals, Cell Movement, Humans, Leukocytes

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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