The DOI matches its Crossref record; 155 of the 155 references it cites were found in a registry or an index.
TBK1, a central kinase in innate immune sensing of nucleic acids and beyond
Open accessAbstract
Sensing of intracellular and extracellular environments is one of the fundamental processes of cell. Surveillance of aberrant nucleic acids, derived either from invading pathogens or damaged organelle, is conducted by pattern recognition receptors (PRRs) including RIG-I-like receptors, cyclic GMP-AMP synthase, absent in melanoma 2, and a few members of toll-like receptors. TANK-binding kinase 1 (TBK1), along with its close analogue I-kappa-B kinase epsilon, is a central kinase in innate adaptor complexes linking activation of PRRs to mobilization of transcriptional factors that transcribe proinflammatory cytokines, type I interferon (IFN-α/β), and myriads interferon stimulated genes. However, it still remains elusive for the precise mechanisms of activation and execution of TBK1 in signaling platforms formed by innate adaptors mitochondrial antiviral signaling protein (MAVS), stimulator of interferon genes protein (STING), and TIR-domain-containing adapter-inducing interferon-β (TRIF), as well as its complex regulations. An atlas of TBK1 substrates is in constant expanding, setting TBK1 as a key node of signaling network and a dominant player in contexts of cell biology, animal models, and human diseases. Here, we review recent advancements of activation, regulations, and functions of TBK1 under these physiological and pathological contexts.
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“TBK1 plays a central role in coordinating the innate immune response in response to cytosolic nucleic acids (e.g. cGAS-STING-TBK1-IRF3-IFN type I pathway) 3 , and enhanced sensitivity to TNF α has been shown to drive cGAS-STING-dependent interferon response and impact cell viability 42 .”
From Targeting TBK1 to overcome resistance to cancer immunotherapy (2023) · cites this paper as [3]
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“TBK1 integrates upstream signals from pattern recognition receptors and cytosolic nucleic acid sensors to regulate the activation of interferon regulatory factor 3 (IRF3) and consequent induction of type I interferons (IFNα / β ) and interferon-stimulated genes (ISGs) critical to the host immune response 3 .”
From Targeting TBK1 to overcome resistance to cancer immunotherapy (2023) · cites this paper as [3]
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Cites
Pattern Recognition Receptors and Inflammation
Takeuchi, O., & Akira, S. (2010) · Cell · doi:10.1016/j.cell.2010.01.022 · Cited by 8,895
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Sun, L., Wu, J., Du, F., Chen, X., & Chen, Z. J. (2013) · Science · doi:10.1126/science.1232458 · Cited by 4,996
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., Schinzel, A. C., Sandy, P., Meylan, E., Scholl, C., et al. (2009) · Nature · doi:10.1038/nature08460 · Cited by 3,922
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Ishikawa, H., & Barber, G. N. (2008) · Nature · doi:10.1038/nature07317 · Cited by 3,576
Seth, R. B., Sun, L., Ea, C.-K., & Chen, Z. J. (2005) · Cell · doi:10.1016/j.cell.2005.08.012 · Cited by 3,329
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Ishikawa, H., Ma, Z., & Barber, G. N. (2009) · Nature · doi:10.1038/nature08476 · Cited by 2,759
IKKε and TBK1 are essential components of the IRF3 signaling pathway
Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S.-M., & Maniatis, T. (2003) · Nature Immunology · doi:10.1038/ni921 · Cited by 2,680
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
Wu, J., Sun, L., Chen, X., Du, F., Shi, H., Chen, C., & Chen, Z. J. (2012) · Science · doi:10.1126/science.1229963 · Cited by 2,628
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Kawai, T., Takahashi, K., Sato, S., Coban, C., Kumar, H., Kato, H., Ishii, K. J., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1243 · Cited by 2,562
Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing
Chen, Q., Sun, L., & Chen, Z. J. (2016) · Nature Immunology · doi:10.1038/ni.3558 · Cited by 2,333
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Metadata
- Authors
- Zhou, R., Zhang, Q., & Xu, P.
- Affiliations
- Zhejiang University (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Venue
- Acta Biochimica et Biophysica Sinica
- Published
- 2020-05-01
- Volume
- 52
- Issue
- 7
- Pages
- 757-767
- ISSN
- 1672-9145 (ISSN-L)
- OpenAlex
- W3032346199
- Cited by
- 104
- References
- 155
- Citations by year
- 2026: 21 · 2025: 9 · 2024: 28 · 2023: 18 · 2022: 11 · 2021: 15 · 2020: 2
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Acta Biochimica et Biophysica Sinica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Initiative Postdocs Supporting Program
- National Natural Science Foundation of China (81902915, 31830052)
- National Natural Science Foundation of China Distinguished Young Scholars Program (31725017)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- TBK1, innate immunity, nucleic acid sensing, pattern recognition receptors, RIG-I-like receptors, STING, MAVS, TRIF, type I interferon, inflammatory cytokines, interferon-stimulated genes, kinase activation, kinase substrates, antiviral signaling
- MeSH terms
- Animals, Humans, Nucleic Acids, Transcription, Genetic, Signal Transduction, Interferon-alpha, Interferon-beta, Protein Serine-Threonine Kinases, Receptors, Pattern Recognition
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