TBK1, a central kinase in innate immune sensing of nucleic acids and beyond

Pattern Recognition Receptors and Inflammation

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Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

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IKKε and TBK1 are essential components of the IRF3 signaling pathway

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Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

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cGAS surveillance of micronuclei links genome instability to innate immunity

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CGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING.

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Triggering the Interferon Antiviral Response Through an IKK-Related Pathway

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Chromosomal instability drives metastasis through a cytosolic DNA response

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

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The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

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DNA sensing by the cGAS–STING pathway in health and disease

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STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

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Cytoplasmic chromatin triggers inflammation in senescence and cancer

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MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

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Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth

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Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

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Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

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Glaucoma

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

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Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

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Structural basis of STING binding with and phosphorylation by TBK1

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TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

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cGAS is essential for cellular senescence

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Cirulli, E. T., Lasseigne, B. N., Petrovski, S., Sapp, P. C., Dion, P. A., Leblond, C. S., Couthouis, J., Lu, Y.-F., Wang, Q., Krueger, B. J., et al. (2015) · Science · doi:10.1126/science.aaa3650 · Cited by 966

The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

Heo, J.-M., Ordureau, A., Paulo, J. A., Rinehart, J., & Harper, J. W. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.08.016 · Cited by 906

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

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The innate immune DNA Sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING.

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STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade

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Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

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STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

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TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation

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Post-Translational Modification Control of Innate Immunity

Liu, J., Qian, C., & Cao, X. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.020 · Cited by 641

NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase

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STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

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IFN-regulatory factor 3-dependent gene expression is defective in Tbk1 -deficient mouse embryonic fibroblasts

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Recognition of Endogenous Nucleic Acids by the Innate Immune System

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TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging

Xu, D., Jin, T., Zhu, H., Chen, H., Ofengeim, D., Zou, C., Mifflin, L., Pan, L., Amin, P., Li, W., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.041 · Cited by 461

STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease

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A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1

Zhao, B., Du, F., Xu, P., Shu, C., Sankaran, B., Bell, S. L., Liu, M., Lei, Y., Gao, X., Fu, X., et al. (2019) · Nature · doi:10.1038/s41586-019-1228-x · Cited by 447

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

Reilly, S. M., Chiang, S.-H., Decker, S. J., Chang, L. C., Uhm, M., Larsen, M. J., Rubin, J. R., Mowers, J. C., White, N. M. A., Hochberg, I., et al. (2013) · Nature Medicine · doi:10.1038/nm.3082 · Cited by 442

Use of the Pharmacological Inhibitor BX795 to Study the Regulation and Physiological Roles of TBK1 and IκB Kinase ϵ

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Activation of STAT6 by STING Is Critical for Antiviral Innate Immunity

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Deficiency of T2K leads to apoptotic liver degeneration and impaired NF‐κB‐dependent gene transcription

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Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKε‐mediated IRF activation

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RalB GTPase-Mediated Activation of the IκB Family Kinase TBK1 Couples Innate Immune Signaling to Tumor Cell Survival

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Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy

Moore, A. S., & Holzbaur, E. L. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1523810113 · Cited by 362

STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum

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The tumour suppressor CYLD is a negative regulator of RIG‐I‐mediated antiviral response

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Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

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Novel cross-talk within the IKK family controls innate immunity

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Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

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The E3 ubiquitin ligase Nrdp1 'preferentially' promotes TLR-mediated production of type I interferon

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Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

Pottier, C., Bieniek, K. F., Finch, N., van de Vorst, M., Baker, M., Perkersen, R., Brown, P., Ravenscroft, T., van Blitterswijk, M., Nicholson, A. M., et al. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1436-x · Cited by 312

Molecular and cellular pathways of neurodegeneration in motor neurone disease

Shaw, P. J. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.048652 · Cited by 311

Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis

Zhao, W., Beers, D. R., & Appel, S. H. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9489-x · Cited by 309

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

Cerboni, S., Jeremiah, N., Gentili, M., Gehrmann, U., Conrad, C., Stolzenberg, M., Pïcard, C., Neven, B., Fischer, A., Amigorena, S., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161674 · Cited by 303

NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4

Cui, J., Li, Y., Zhu, L., Liu, D., Songyang, Z., Wang, H. Y., & Wang, R. (2012) · Nature Immunology · doi:10.1038/ni.2239 · Cited by 301

Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood

Casadio, M., Ciancanelli, M. J., Ou, Y.-H., Lorenzo, L., Klaudel‐Dreszler, M., Pauwels, E., Sancho‐Shimizu, V., de Diego, R. P., Abhyankar, A., Israelsson, E., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111316 · Cited by 292

Zika Virus Disrupts Phospho-TBK1 Localization and Mitosis in Human Neuroepithelial Stem Cells and Radial Glia

Onorati, M., Li, Z., Liu, F., Sousa, A. M. M., Nakagawa, N., Li, M., Dell’Anno, M. T., Gulden, F. O., Pochareddy, S., Tebbenkamp, A. T. N., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.038 · Cited by 292

HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

Wu, S., Zhang, Q., Zhang, F., Meng, F., Liu, S., Zhou, R., Wu, Q., Li, X., Shen, L., Huang, J., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0352-z · Cited by 278

Severe Acute Respiratory Syndrome Coronavirus M Protein Inhibits Type I Interferon Production by Impeding the Formation of TRAF3·TANK·TBK1/IKKϵ Complex

Siu, K., Kok, K., Ng, M.-H. J., Poon, V. K., Yuen, K., Zheng, B.-J., & Jin, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.008227 · Cited by 276

The critical role of toll-like receptors — From microbial recognition to autoimmunity: A comprehensive review

Jimenez-Dalmaroni, M. J., Gerswhin, M. E., & Adamopoulos, I. E. (2015) · Autoimmunity Reviews · doi:10.1016/j.autrev.2015.08.009 · Cited by 271

Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

Larabi, A., Devos, J. M., Ng, S., Nanao, M., Round, A. R., Maniatis, T., & Panne, D. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.034 · Cited by 253

TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue

Zhao, P., Wong, K. I., Sun, X., Reilly, S. M., Uhm, M., Liao, Z., Skorobogatko, Y., & Saltiel, A. R. (2018) · Cell · doi:10.1016/j.cell.2018.01.007 · Cited by 250

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

Luo, W., Li, S., Li, C., Lian, H., Yang, Q., Zhong, B., & Shu, H. (2016) · Nature Immunology · doi:10.1038/ni.3510 · Cited by 249

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

Ma, X., Helgason, E., Phung, Q. T., Quan, C. L., Iyer, R. S., Lee, M. W., Bowman, K. K., Starovasnik, M. A., & Dueber, E. C. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121552109 · Cited by 246

SHP-2 Phosphatase Negatively Regulates the TRIF Adaptor Protein-Dependent Type I Interferon and Proinflammatory Cytokine Production

An, H., Zhao, W., Hou, J., Zhang, Y., Xie, Y., Zheng, Y., Xu, H., Qian, C., Zhou, J., Yu, Y., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.10.014 · Cited by 244

Copy number variations on chromosome 12q14 in patients with normal tension glaucoma

Fingert, J. H., Robin, A. L., Stone, J. L., Roos, B. R., Davis, L. K., Scheetz, T. E., Bennett, S. R., Wassink, T. H., Kwon, Y. H., Alward, W. L. M., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr123 · Cited by 228

Dengue Virus NS Proteins Inhibit RIG-I/MAVS Signaling by Blocking TBK1/IRF3 Phosphorylation: Dengue Virus Serotype 1 NS4A Is a Unique Interferon-Regulating Virulence Determinant

Dalrymple, N. A., Cimica, V., & Mackow, E. R. (2015) · mBio · doi:10.1128/mbio.00553-15 · Cited by 228

IκB kinase ε and TANK-binding kinase 1 activate AKT by direct phosphorylation

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TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Ou, Y.-H., Torres, M. J., Ram, R. R., Formstecher, É., Roland, C. L., Cheng, T., Brekken, R. A., Wurz, R. P., Tasker, A. S., Polverino, T., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.019 · Cited by 224

Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1

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ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response

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TRIM23 mediates virus-induced autophagy via activation of TBK1

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