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Genomic, phylogenetic, and cell biological insights into metazoan origins
Abstract
Over 600 million years ago, the first multicellular metazoans evolved from their single celled ancestors. Although not recorded in the fossil record, the earliest events in metazoan evolution can be inferred by integrating findings from phylogenetics, genomics, and cell biology. Comparisons of choanoflagellate — microeukaryote relatives of metazoans, with sponges (the earliest known metazoans) — reveal genetic innovations associated with metazoan origins. Among these are the evolution of gene families required for cell adhesion and cell signaling, the presence of which catalyzed the evolution of multicellularity and whose functions have since been elaborated to regulate cell differentiation, developmental patterning, morphogenesis, and the functional integration of tissues. The most ancient tissues — differentiated epithelia — are found in sponges and evolved before the origin and diversification of modern phyla.
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“This suggests that the similarities between choanocytes and choanoflagellates were inherited from a common ancestor and that the choanocytebased feeding mode, as retained by sponges, is likely ancestral to all animals (29).”
From Oxygen requirements of the earliest animals (2014) · cites this paper as [29]
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Metadata
- Authors
- Nichols, S. A., Dayel, M. J., & King, N.
- Venue
- Animal Evolution
- Publisher
- Oxford University PressOxford
- Published
- 2009-08-01
- Pages
- 24-32
- OpenAlex
- W2502404727
- Cited by
- 24
- References
- 1,066
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 4 · 2012: 1
- FWCI
- 13.67
- Type
- book chapter
- Language
- en
- Open access
- closed
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
- Keywords
- metazoan origin, evolution of multicellularity, choanoflagellates, sponges, cell adhesion genes, gene family evolution, metazoan phylogeny, cell differentiation, morphogenesis
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