The Wnt Signaling Pathway in Development and Disease

Logan, Catriona Y.; Nusse, Roel

doi:10.1146/annurev.cellbio.20.010403.113126

Cited by 5,325Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationHedgehog Signaling Pathway Studies

The Wnt Signaling Pathway in Development and Disease

Logan, Catriona Y., Nusse, Roel·2004·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.20.010403.113126

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Abstract

▪ Abstract Tight control of cell-cell communication is essential for the generation of a normally patterned embryo. A critical mediator of key cell-cell signaling events during embryogenesis is the highly conserved Wnt family of secreted proteins. Recent biochemical and genetic analyses have greatly enriched our understanding of how Wnts signal, and the list of canonical Wnt signaling components has exploded. The data reveal that multiple extracellular, cytoplasmic, and nuclear regulators intricately modulate Wnt signaling levels. In addition, receptor-ligand specificity and feedback loops help to determine Wnt signaling outputs. Wnts are required for adult tissue maintenance, and perturbations in Wnt signaling promote both human degenerative diseases and cancer. The next few years are likely to see novel therapeutic reagents aimed at controlling Wnt signaling in order to alleviate these conditions.

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In deregulated forms, the Wnt/β-catenin signaling pathway is involved in human cancers and developmental disorders.
“In deregulated forms, it is involved in human cancers and developmental disorders [26, 27].”
From Relating simulation studies by provenance—Developing a family of Wnt signaling models (2021) · cites this paper as [27]

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Authors: Logan, C. Y., & Nusse, R.
Affiliations: Howard Hughes Medical Institute (US)
Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, Stanford, California 94305;,
ORCID: Logan, Catriona Y.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2004-11-01
Volume: 20
Issue: 1
Pages: 781-810
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.20.010403.113126
OpenAlex: W2119284420
Cited by: 5,325
References: 13
Citations by year: 2026: 84 · 2025: 121 · 2024: 133 · 2023: 186 · 2022: 185 · 2021: 257 · 2020: 267 · 2019: 211 · 2018: 253 · 2017: 267 · 2016: 264 · 2015: 321 · 2014: 308 · 2013: 346 · 2012: 354
FWCI: 14.87
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt signaling, Wnt proteins, cell-to-cell communication, embryonic development, canonical Wnt pathway, receptor ligand specificity, feedback loops, tissue maintenance, degenerative diseases, cancer
MeSH terms: Animals, Cell Nucleus, Cytoplasm, Disease, Gene Expression Regulation, Glycoproteins, Humans, Neoplasms, Proto-Oncogene Proteins, Signal Transduction, Protein Transport, Intercellular Signaling Peptides and Proteins, Embryonic Development, Wnt Proteins

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The Wnt Signaling Pathway in Development and Disease

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